Faculty Scholarship
Showing 411 - 420 of 733 Items
Date: 2012-08-30
Creator: Mary Rogalski
Access: Open access
Date: 2017-01-01
Creator: Emilie Dassié, Kristine Delong, Hali Kilbourne, Branwen Williams, Nerilie, Abram, Logan Brenner, Chloé Brahmi, Kim M. Cobb, Thierry Corrège, Delphine Dissard, Julien Emile-Geay, Heitor Evangelista, Michael N. Evans, Jesse Farmer, Thomas Felis, Michael Gagan, David P. Gillikin, Nathalie Goodkin, Myriam Khodri, Ana Carolina Lavagnino, Michèle Lavigne, Claire Lazareth, Braddock Linsley, Janice Lough, Helen McGregor, Intan S. Nurhati, Gilman Ouellette, Laura Perrin, Maureen Raymo, Brad Rosenheim, Michael Sandstrom, Bernd R. Schöne
Access: Open access
Date: 2016-02-25
Creator: B. Zorina Khan
Access: Open access
- The French economy has been criticized for a lack of integration of women in business and for the prevalence of inefficient family firms. A sample drawn from patent and exhibition records is used to examine the role of women in enterprise and invention in France. Middle-class women were extensively engaged in entrepreneurship and innovation, and the empirical analysis indicates that their commercial efforts were significantly enhanced by association with family firms. Such formerly invisible achievements suggest a more productive role for family-based enterprises, as a means of incorporating relatively disadvantaged groups into the market economy as managers and entrepreneurs. This business model .... melds entrepreneurial passion with a long family tradition. - Wendel Company (1704-2014) 1
Date: 1994-01-01
Creator: M. S. Alam, I. J. Kim, B. Nemati, J. J. ONeill, H., Severini, C. R. Sun, M. M. Zoeller, G. Crawford, C. M. Daubenmier, R. Fulton, D. Fujino, K. K. Gan, K. Honscheid, H. Kagan, R. Kass, J. Lee, R. Malchow, F. Morrow, Y. Skovpen, M. Sung, C. White, F. Butler, X. Fu, G. Kalbfleisch, W. R. Ross, P. Skubic, J. Snow, P. L. Wang, M. Wood, D. N. Brown, J. Fast
Access: Open access
- We have fully reconstructed decays of both B»0 and B- mesons into final states containing either D, D*, D**, , or c1 mesons. This allows us to obtain new results on many physics topics including branching ratios, tests of the factorization hypothesis, color suppression, resonant substructure, and the B - B»0 mass difference. © 1994 The American Physical Society.
Date: 2019-07-10
Creator: Mark O. Battle, J. William Munger, Margaret Conley, Eric Sofen, Rebecca, Perry, Ryan Hart, Zane Davis, Jacob Scheckman, Jayme Woogerd, Karina Graeter, Samuel Seekins, Sasha David, John Carpenter
Access: Open access
- Measurements of atmospheric O2 have been used to quantify large-scale fluxes of carbon between the oceans, atmosphere and land since 1992 (Keeling and Shertz, 1992). With time, datasets have grown and estimates of fluxes have become more precise, but a key uncertainty in these calculations is the exchange ratio of O2 and CO2 associated with the net land carbon sink (B). We present measurements of atmospheric O2 and CO2 collected over a 6-year period from a mixed deciduous forest in central Massachusetts, USA (42.537 N, 72.171 W). Using a differential fuel-cellbased instrument for O2 and a nondispersive infrared analyzer for CO2, we analyzed airstreams collected within and 5m above the forest canopy. Averaged over the entire period of record, we find these two species covary with a slope of -1:081±0:007 mol of O2 per mole of CO2 (the mean and standard error of 6 h periods). If we limit the data to values collected on summer days within the canopy, the slope is -1:03±0:01. These are the conditions in which biotic influences are most likely to dominate. This result is significantly different from the value of -1.1 widely used in O2-based calculations of the global carbon budget, suggesting the need for a deeper understanding of the exchange ratios of the various fluxes and pools comprising the net sink.
Date: 1993-12-01
Creator: D. S. Akerib, B. Barish, M. Chadha, D. F. Cowen, G., Eigen, J. S. Miller, J. Urheim, A. J. Weinstein, D. Acosta, G. Masek, B. Ong, H. Paar, M. Sivertz, A. Bean, J. Gronberg, R. Kutschke, S. Menary, R. J. Morrison, H. N. Nelson, J. D. Richman, H. Tajima, D. Schmidt, D. Sperka, M. S. Witherell, M. Procario, S. Yang, M. Daoudi, W. T. Ford, D. R. Johnson, K. Lingel, M. Lohner
Access: Open access
Date: 2016-07-26
Creator: Richard S. Dodd, Vladimir Douhovnikoff
Access: Open access
- The earth is experiencing major changes in global and regional climates and changes are predicted to accelerate in the future. Many species will be under considerable pressure to evolve, to migrate, or be faced with extinction. Clonal plants would appear to be at a particular disadvantage due to their limited mobility and limited capacity for adaptation. However, they have outlived previous environmental shifts and clonal species have persisted for millenia. Clonal spread offers unique ecological advantages, such as resource sharing, risk sharing, and economies of scale among ramets within genotypes. We suggest that ecological attributes of clonal plants, in tandem with variation in gene regulation through epigenetic mechanisms that facilitate and optimize phenotype variation in response to environmental change may permit them to be well suited to projected conditions.
Date: 2014-09-16
Creator: M. O. Battle, J. P. Severinghaus, E. D. Sofen, D. Plotkin, A. J., Orsi, M. Aydin, S. A. Montzka, T. Sowers, P. P. Tans
Access: Open access
Date: 2019-01-01
Creator: Patsy S. Dickinson, Evyn S. Dickinson, Emily R. Oleisky, Cindy D. Rivera, Meredith E., Stanhope, Elizabeth A. Stemmler, J. Joe Hull, Andrew E. Christie
Access: Open access
- Recent genomic/transcriptomic studies have identified a novel peptide family whose members share the carboxyl terminal sequence –GSEFLamide. However, the presence/identity of the predicted isoforms of this peptide group have yet to be confirmed biochemically, and no physiological function has yet been ascribed to any member of this peptide family. To determine the extent to which GSEFLamides are conserved within the Arthropoda, we searched publicly accessible databases for genomic/transcriptomic evidence of their presence. GSEFLamides appear to be highly conserved within the Arthropoda, with the possible exception of the Insecta, in which sequence evidence was limited to the more basal orders. One crustacean in which GSEFLamides have been predicted using transcriptomics is the lobster, Homarus americanus. Expression of the previously published transcriptome-derived sequences was confirmed by reverse transcription (RT)-PCR of brain and eyestalk ganglia cDNAs; mass spectral analyses confirmed the presence of all six of the predicted GSEFLamide isoforms – IGSEFLamide, MGSEFLamide, AMGSEFLamide, VMGSEFLamide, ALGSEFLamide and AVGSEFLamide – in H. americanus brain extracts. AMGSEFLamide, of which there are multiple copies in the cloned transcripts, was the most abundant isoform detected in the brain. Because the GSEFLamides are present in the lobster nervous system, we hypothesized that they might function as neuromodulators, as is common for neuropeptides. We thus asked whether AMGSEFLamide modulates the rhythmic outputs of the cardiac ganglion and the stomatogastric ganglion. Physiological recordings showed that AMGSEFLamide potently modulates the motor patterns produced by both ganglia, suggesting that the GSEFLamides may serve as important and conserved modulators of rhythmic motor activity in arthropods.
Date: 2018-09-01
Creator: Giap H. Vu, Daniel Do, Cindy D. Rivera, Patsy S. Dickinson, Andrew E., Christie, Elizabeth A. Stemmler
Access: Open access
- We report on the characterization of the native form of an American lobster, Homarus americanus, β-defensin-like putative antimicrobial peptide, H. americanus defensin 1 (Hoa-D1), sequenced employing top-down and bottom-up peptidomic strategies using a sensitive, chip-based nanoLC-QTOF-MS/MS instrument. The sequence of Hoa-D1 was determined by mass spectrometry; it was found to contain three disulfide bonds and an amidated C-terminus. The sequence was further validated by searching publicly-accessible H. americanus expressed sequence tag (EST) and transcriptome shotgun assembly (TSA) datasets. Hoa-D1, SYVRScSSNGGDcVYRcYGNIINGAcSGSRVccRSGGGYamide (with c representing a cysteine participating in a disulfide bond), was shown to be related to β-defensin-like peptides previously reported from Panulirus japonicas and Panulirus argus. We found Hoa-D1 in H. americanus hemolymph, hemocytes, the supraoesophageal ganglion (brain), eyestalk ganglia, and pericardial organ extracts, as well as in the plasma of some hemolymph samples. Using discontinuous density gradient separations, we fractionatated hemocytes and localized Hoa-D1 to hemocyte sub-populations. While Hoa-D1 was detected in semigranulocytes and granulocytes using conventional proteomic strategies for analysis, the direct analysis of cell lysates exposed evidence of Hoa-D1 processing, including truncation of the C-terminal tyrosine residue, in the granulocytes, but not semigranulocytes. These measurements demonstrate the insights regarding post-translational modifications and peptide processing that can be revealed through the MS analysis of intact peptides. The identification of Hoa-D1 as a widely-distributed peptide in the lobster suggests the possibility that it may be pleiotropic, with functions in addition to its proposed role as an antimicrobial molecule in the innate immune system.