Honors Projects
Showing 351 - 400 of 662 Items

- Embargo End Date: 2027-05-19
Date: 2022-01-01
Creator: Alexander Avrom Kreines
Access: Embargoed
Date: 2022-01-01
Creator: Sebastian de Lasa
Access: Open access
- The rise of Euskadi Ta Askatasuna (ETA) in the early 1970s coincided with the rise of national liberation movements across Europe, which largely were inspired by notable examples of resistance throughout the Global South in the decades prior. ETA’s growth over this period, and in the years prior, was heavily dependent on the image created of the organziation in the local, domestic, and international press, including through documents distributed by the group itself. By comparing ETA’s external presence to the group’s internal strife, it becomes clear that ETA made efforts to align itself with the popular revolutionary language of the period. The group took advantage of, and aimed to create press spectacles, in attempts to manipulate its public image. However, the discrepancy between the group’s public image and internal dissolution became apparent as the group pursued more violent acts in the goal of Basque liberation.

Date: 2013-05-01
Creator: Patrick J Lariviere
Access: Access restricted to the Bowdoin Community

- Restriction End Date: 2025-06-01
Date: 2022-01-01
Creator: Warsameh Bulhan
Access: Access restricted to the Bowdoin Community
Date: 2022-01-01
Creator: Brigita Kant
Access: Open access
- For centuries, the Pacific Islands have been disguised by Europeans through the trope of “island paradise." Despite Europe’s role in bringing colonization and racial oppression to Oceania, the dominant narrative has been that Pacific Islanders lead simple lives, untouched from the complicated aspects of the “modern world.” This narrative has enabled White outsiders to fantasize about the Pacific Islands as a place for personal denial of Western social conventions, simultaneously allowing White European men to fetishize and possess Pacific Island culture and identity. My honors project will closely examine three fictional German language texts- Haimotochare (1819), Der Papalagi (1920), and Imperium (2012)- centered around the exploration German colonial involvement in Pacific Islands. My analysis of these texts will allow for the understanding of how the false narrative of “island paradise” came to be, how it has been embraced and weaponized, and what it means for both German and Pacific Islander post-colonial identity.
Date: 2022-01-01
Creator: Stephen Crawford
Access: Open access
- In the past decade, numerous datasets have been released with the explicit goal of furthering non-intrusive load monitoring research (NILM). NILM is an energy measurement strategy that seeks to disaggregate building-scale loads. Disaggregation attempts to turn the energy consumption of a building into its constituent appliances. NILM algorithms require representative real-world measurements which has led institutions to publish and share their own datasets. NILM algorithms are designed, trained, and tested using the data presented in a small number of these NILM datasets. Many of the datasets contain arbitrarily selected devices. Likewise, the datasets themselves report aggregate load information from building(s) which are similarly selected arbitrarily. This raises the question of the representativeness of the datasets themselves as well as the algorithms based on their reports. One way to judge the representativeness of NILM datasets is to look for the presence of outliers in these datasets. This paper presents a novel method of identifying outlier devices from NILM datasets. With this identification process, it becomes possible to mitigate and measure the impact of outliers. This represents an important consideration to the long-term deployment of NILM algorithms.
Date: 2022-01-01
Creator: Ella Pearl Crabtree
Access: Open access
- “‘Possessive Gentleness’: Insecure Attachments in American Literature” applies psychological attachment theory to works of American Literature. Each novel examined—Uncle Tom’s Cabin (1851), Dred: A Tale of the Dismal Swamp (1856), and The Minister’s Wooing (1859) by Harriet Beecher Stowe, The Third Generation (1954) by Chester Himes, and The Bluest Eye (1970) by Toni Morrison—describes the forces behind insecure attachment relationships between child characters and their caregivers. The first chapter of this project focuses on Stowe’s anti-slavery novels. It argues that the institution of slavery is in conflict with Christianity in these works, because it impedes disinterestedly benevolent mothering and disrupts secure attachments. The second chapter analyzes The Third Generation, and suggests that colorism in the black community is the cause of insecure attachments in Himes’ work. The third and final chapter examines The Bluest Eye, and presents sympathy, as embodied by the novel’s narrator, as a potential remedy for insecure parent-child attachments. Together, these texts elucidate how societal forces (e.g. colorism, poverty) intrude upon the family structure and destabilize parent-child attachments. Optimistically, however, they also suggest that improved parent-child attachments might function as a vehicle of broader social change.
Date: 2022-01-01
Creator: Brianna Cunliffe
Access: Open access
- Although wood pellet biomass corporations frame their recent rapid growth as a victory for “green energy”, troubling evidence of their adverse impacts on climate and environmental justice calls for rigorous investigation of these claims. Contextualizing biomass within the envirotechnical regimes that have created industrial ‘sacrifice zones’ in BIPOC low-income communities in the US South, this paper recharacterizes it as an innovation within oppressive regimes. It further critiques carbon accounting frameworks that designate biomass as renewable despite its greater emissions per capita than coal and carbon debts created by deforestation that could take centuries to rectify. Biomass pellet production plants, cited disproportionately in environmental justice communities, also emit serious and often under-reported amounts of pollutants including PM 2.5, VOCs, and HAPs, linked to higher rates of chronic illness and premature death in impacted communities. The current regulatory paradigm guarantees neither distributive nor procedural justice. Ethnographic research including participant-observation, interviews, and site visits revealed that community members felt that regulatory bodies serve corporations above vulnerable citizens, that their voices were not valued in public hearings or by elected officials, and that the pollution, dishonesty, and ecological harms plants bring far outweighs their meagre economic benefits. Communities enact robust resistance to biomass as both a global climate threat and a local injustice. This paper traces how coalitions connecting intersectional grassroots activist networks to larger advocacy organizations are achieving victories on the ground and in the court of public opinion, and the lessons this synergy holds for the endeavor of a truly just transition.
Date: 2022-01-01
Creator: Devaki Rajiv
Access: Open access
- The binding of adjacent cells to one another, or cell adhesion, is critical for the growth and development of multicellular organisms. In plant cells, much evidence suggests that the amount and modification of pectin in the cell wall largely determines how well cell adhesion occurs. ELMO1 is a Golgi protein involved in pectin-mediated cellular adhesion, and mutations in ELMO1 lead to disrupted cell organization in Arabidopsis. ELMO1 is predicted to be a scaffold for pectin biosynthesis enzymes, and thus its absence leads to the adhesion-defective phenotype of elmo1-/- plants. There are four other ELMO homologues (ELMO2,3,4 and 5) which remain to be characterized as to their function and role in cell adhesion. This thesis focuses on the characterization of ELMO2, which has 79% amino acid similarity with ELMO1. A genetic analysis that evaluated elmo2 double mutants revealed that ELMO2 and ELMO1 have redundant functions. elmo1-/-/2-/- double mutants, but not elmo2-/- or elmo1-/- single mutants, have reduced tensile strengths. While elmo1-/- phenotypes are most pronounced in liquid media, they are partially rescued by growth on agar, suggesting a role of turgor in maintaining cell adhesion. Like ELMO1, ELMO2-GFP colocalizes with Golgi markers. The results suggest that like ELMO1, ELMO2 also functions as a scaffold for pectin biosynthesis enzymes in the Golgi.

Date: 2023-01-01
Creator: Katharine Barrett
Access: Access restricted to the Bowdoin Community

- Restriction End Date: 2026-06-01
Date: 2021-01-01
Creator: Aida Muratoglu
Access: Access restricted to the Bowdoin Community
Date: 2021-01-01
Creator: Gavin T Shilling
Access: Open access
- The Great Recession of 2007 and 2008 exposed the risks of excessive borrowing. We learned the essential economic principle that greater leverage harbors greater risk. Although this global economic contraction was driven primarily by booming private credit expansion, economically inefficient incentives in the public sector, such as short-term reelection concerns, may lead politicians to engage in rash deficit- financed, fiscal spending. The primary purpose of this research is to assess the economic costs of heightened, preexisting government leverage on real economic outcomes during recessionary periods, focusing on both banking and non-banking crisis recessions. In both advanced economies and emerging economies, this study confirms that banking recessions are associated with more severe economic contractions and more persistent output declines than normal recessions. In advanced economies, GDP recovers quickly and strongly with expansionary and supportive fiscal policy during low debt recessions, even with depressed private investment. While GDP recovers slowly and weakly with less expansionary fiscal policy during high debt recessions, even with strong private investment. Thus, the social marginal benefit of public sector investment exceeds the social marginal benefit of private sector investment in advanced economies. In emerging economies, GDP recovers quickly and strongly with strong private investment during high debt recessions, even with weak fiscal spending. While GDP recovers slowly and weakly with depressed private investment during low debt recessions, even with expansionary and supportive fiscal policy. Thus, the social marginal benefit of private sector investment exceeds the social marginal benefit of public sector investment in emerging economies.
Date: 2021-01-01
Creator: Claire M Burns
Access: Open access
- This project considers how the novels of contemporary Scottish author Ali Smith work to destabilize traditional constructions of temporal, formal, national, and gender borders. The motifs of the border and the border identity have been thematically pervasive in Scottish literary history, as reflected in the recurrence of the Scottish split identity. This thesis explores how the borders that have become essential to the construction of Scottish national literature, often relying on binaristic categorizations, have been disestablished in the contemporary era. Ali Smith’s novels, particularly the novels of her seasonal quartet, introduce forms and figures that highlight the instability of many of these borders, challenging fixed representations of the border identity. Through this focus on Scotland, Smith constructs a template for a consideration of national identity beyond the boundaries of Scotland, extending toward a more global sensibility.
Date: 2021-01-01
Creator: Archer Thomas
Access: Open access
- The switch from late modernism to postmodernism in Western aesthetic theory and criticism took place in the mid-to-late 20th century, radically changing the face of cultural criticism. Much has been written on how postmodernism broke from modernism, but what factors paved its way in the decades following the Second World War? This paper argues that postmodernism represents both a reaction to and a necessary evolution of late modernism, specifically as it manifests in architecture, politics, and the politics of architecture. It focuses on the crisis of confidence among Western left-wing circles following the upheaval of the Second World War and posits that, because of this upheaval, primitivism came to dominate the epistemology of a renewed modernism led by figures such as Clement Greenberg, Reyner Banham, and the practitioners of “the New Brutalism.” The paper then explores how the Western left-wing reaction to developments like decolonization and postwar modernization challenged primitivity’s newfound importance, resulting in a shift towards a “postmodern populism” in aesthetics and politics by the 1960s as described by Jean Baudrillard, Fredric Jameson, Robert Venturi, and Reyner Banham.
Date: 2021-01-01
Creator: Brianna Madison Canning
Access: Open access
- Organized crime related violence in Mexico remains at unprecedented levels despite decades of effort and billions of dollars spent attempting to weaken Transnational Criminal Organizations (TCOs) through the Mérida Initiative (MI): a bilateral security partnership established in October 2007 between US President George W. Bush and Mexican President Felipe Calderón. The MI sought to combat TCOs (often called cartels), their drug trafficking operations, and their networks of corruption. However, since then TCOs have expanded their businesses beyond drug trafficking, and they have adopted violent practices that target civilians. Extortion, torture, murder, and human trafficking have become common as TCOs look to other illicit markets to make up for losses in drug profits, and to signal strength to their opponents. More specifically, the homicide rate in Mexico increased by more than 100% between 2007 and 2008, aligning with the creation of the initiative designed to have the opposite effect. However, case study research into the violence in Ciudad Juárez and Tijuana determined that the MI was not actually implemented until mid-2009 because of bureaucratic delays, meaning it did not impact the initial spike in homicides in Mexico in 2008. Instead, the violence starting in 2008 is a result of changing dynamics between and within TCOs, as they adapted to survive and maintain control of resources. By supporting the Mexican government’s drug war efforts over the next several years, the Mérida Initiative became one of many complex domestic and international factors that ultimately contributed to extreme levels of violence in Mexico.

- Embargo End Date: 2026-05-20
Date: 2021-01-01
Creator: Jialin Xie
Access: Embargoed
Date: 2021-01-01
Creator: Michael Borecki
Access: Open access
- Small donors have provided an increased share of total campaign contributions in the 2016, 2018, and 2020 U.S. federal election cycles, including about $3 billion of the $14.4 billion raised in 2020. Campaign funding is still dominated by an influential set of large donors, but small donations may be the basis for an effective response to the disproportionate amount of “big money” in politics. This study investigates whether candidates who are more extreme perform better with small donors, and then examines the impact of small donations and overall funding on election results. These analyses were performed using linear sum-of-squares regression models. The results in Chapter 2 show that candidates who are more politically-extreme receive more of their funding from small donations, but perform worse in general elections when fundraising is equal. Chapter 3 shows that small donations do not have an impact on candidate performance in general elections more generally, but candidates who outraise their opponent also outperform relative to the district’s partisan lean. However, that effect disappears when looking only at elections decided by less than 10 percent of the vote. These results suggest that small donors are more likely to support candidates who are more politically polarized, but the effects of small donors on the makeup of Congress is marginal at best, at least as far as general election outcomes are concerned. The project concludes by considering reform proposals that seek to broaden the pool of Americans who donate small sums to political candidates.
Date: 2023-01-01
Creator: Maya Y. Chandar-Kouba
Access: Open access
- Monitoring forest carbon storage is necessary in accurately modelling the global carbon cycle. In the Northeast, terrestrial forests represent a major carbon sink with above-ground biomass (AGB) accounting for 40% of stored forest carbon. Therefore, understanding how AGB varies spatiotemporally is essential in predicting future carbon storage. Repeated measurements in permanent, long-term plots provide an opportunity to examine how carbon stored in AGB is changing over time. I used 29 years of data from the Harvard Forest Environmental Monitoring Systems (HF EMS) Site to determine how stand composition, intrinsic factors, and extrinsic environmental factors influenced rates of carbon storage in AGB over time. Using a partition around medoids (PAM) clustering method, I separated the 34 ground plots at the EMS stand into their respective stand types. I found that each stand type at the HF EMS plots accumulates carbon at consistent rates throughout the study period, although rates of carbon accumulation between stands were significantly different. Red Pine stands experience a rapid decline in biomass in 2018 due to the introduction of the Southern Pine Beetle. Across all stand types, sporadic mortality events determine variations in yearly rates of carbon accumulation, although this has little significant influence on total AGB accumulation. Leaf area index (LAI) and foliar N contents have no effect on growth increments. Extrinsic environmental variables had mixed effects on growth and mortality, highlighting the complexities of predicting forest carbon storage under changing climate conditions.
Date: 2023-01-01
Creator: Kenneth Garcia
Access: Open access
- Neuromodulation allows for the flexibility of neural circuit dynamics and the outputs they produce. Studies of the stomatogastric nervous system (STNS) have expanded our knowledge on the actions of neuromodulators, small molecules that most often activate G-protein coupled receptors and reconfigure circuit activity and composition. In these systems, modulation has been found to occur at every level, from sensory-motor coupling to neuromuscular transmission (Harris-Warrick and Marder 1991). Neuromodulators have complex effects on motor output; they can alter the firing of individual neurons while also modulating muscle properties, neuromuscular transmission, and sensory neuron response to muscle activity (Fort et al. 2004). We investigated this further by recording the motor output produced by the gastric mill rhythm of the lobster STNS under neuromodulator conditions. How is this neuromuscular system as a whole modulated to produce motor flexibility? We hypothesized that these neuromodulators act on individual receptors of component neurons of central pattern generator (CPG)-effector system themselves and at the periphery, coordinately altering muscle contraction by altering all levels of the crustacean neuromuscular system. Application of NRNFLRFamide, RPCH, oxotremorine, and proctolin to the gastric mill 4 (gm4) muscles of the Cancer crab showed that neuromodulators that have been found to have variable, yet significant effects on the activity of the neurons of the STNS directly alter the activity of the gm4 muscles as well, suggesting that coordination of peripheral actions and direct neuronal modulation regulates patterned motor output.

- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Lily Randall
Access: Embargoed

- Restriction End Date: 2028-06-01
Date: 2023-01-01
Creator: Ean Lev Small
Access: Access restricted to the Bowdoin Community
Date: 2023-01-01
Creator: Jane L. Godiner
Access: Open access
- "Invisible Ailments" is a collection of short stories that trace the depth, breath, and sweeping range of lived experiences of people struggling with mental illness. While it is a work of fiction, the people in these stories might feel eerily familiar — to your friends, your family members, your loved ones, or, if you're brave enough to admit it, yourself.

- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Holden D. Hadfield
Access: Embargoed

- Restriction End Date: 2028-06-01
Date: 2023-01-01
Creator: Jada Scotland
Access: Access restricted to the Bowdoin Community
Date: 2023-01-01
Creator: Rowland Luo
Access: Open access
- The study of neuronal development could provide foundational information on neurogenesis and neuroplasticity. The small size and relatively simple nervous system of Orthoptera make them ideal models for neurodevelopmental studies. The peripheral nervous system development is an intricate and precise process that each sensory neurons are able to reach their central nervous system partners in a relatively short amount of time. Although the peripheral nervous system in limb buds and their genetic regulations are well understood in grasshopper embryos, few studies have explored the developing nervous system in a cricket model. Therefore, the first goal of the current experiment is to characterize the normal peripheral nervous system development in cricket embryos. Previous studies in Drosophila have suggested Toll6 and Toll7 receptors could serve as important targets for the neurotrophic-like factors Spaetzle2 and 5. Malfunctioning neurotrophic pathways could lead to abnormal nervous system development. Therefore, the second goal of the current study is to explore the roles of Toll7 in the development of the cricket peripheral nervous system. Immunohistochemical staining using anti-horseradish peroxidase (Anti-HRP) was used to illustrate crickets' embryonic developing peripheral nervous system in the limb buds from developmental stage 7.0 to 11.0. Cricket eggs were injected with Toll7 double stranded RNA (dsRNA) and rhodamine dye to suppress the Toll7 mRNA level. The control eggs were injected with GFP dsRNA and rhodamine dye. The peripheral nervous system development in cricket embryos is largely homologous to that observed in grasshopper embryos. All later-emerged sensory neurons followed the pathway established by the first pioneer neuron Ti1. Ti1 made stereotypical turns following the steering signals on epithelial and guidepost cell surfaces and eventually fasciculate with lateral motor axons from the central nervous system. When examining the peripheral nervous system development with Toll7 knockdown, a decrease in limb bud volume was observed at stage 7.7 and stage 8.0, suggesting Toll7’s potential roles in aiding cell-cell intercalation processes in Orthoptera embryos. Furthermore, a delay in Ti1 pioneer neuron development was observed with Toll7 knockdown at early developmental stages, providing evidence for Toll-Spaetzle pathway’s neurotrophic-like functions. The results of the current experiment provide the first description of the peripheral nervous system development in the cricket limb buds and further evidence of Toll-Spaetzle pathway’s neurotrophic properties.

- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Bjorn Ludwig
Access: Embargoed
Date: 2023-01-01
Creator: Colby Silva Santana
Access: Open access
- Of Russia's cultural and religious icons, the holy fool (iurodivy) is quite possibly the most significant one of contemporary times. The holy fool – a historical and cultural character that feigns insanity to produce moral and spiritual reflections and hide the purity of their souls – has left its traces over a significant portion of Russia's literary history, postmodern tradition, and socio-political thought. In its uniquely positioned role as a powerful form of institutional critique, today taking shape in modern-day political protest performance culture, the holy fool has often been utilized to interrogate the intertwined relationship of the Russian state and the Orthodox Church. This analysis reviews the scholarship on holy foolery and how it has manifested in various fields of study. Although scholarship on this subject is significant, there exists a lack of research into representation of the holy fool in contemporary Russian cinema. Cinema is uniquely positioned to portray holy foolery, thanks to the unique form of spectatorship the film camera allows. This thesis analyzes several case studies of 21st-century Russian cinema that feature characters representing qualities of iurodstvo and its related models. In doing so, this work traces the history and development of iurodstvo through the lens of cinema and suggests new ways of understanding holy foolery's manifestation as a political tool.
Date: 2023-01-01
Creator: Hafsa Hossain
Access: Open access
- In 1985, Mohd. Ahmad Khan v. Shah Bano Begum, known commonly as the Shah Bano Case, became a flashpoint for Indian democracy. The Shah Bano case revolved around the maintenance of a divorced woman, not the first of its kind by any means. A case that sparked major social and political upheaval during a broader period of political turmoil, the Shah Bano case has long been interpreted as an expression of the crisis and contradictions between the democratic rights of women as citizens and the democratic rights of Muslims as a religious minority in the Indian nation-state. In the immediate aftermath of the case, critical feminist and post-colonial scholarship grappled with the dilemmas it involved, but to some extent remained caught up in those dilemmas. This thesis builds upon the important work of these and later scholars, but it also draws new attention to the specific role of the English-language public sphere in shaping the terms of debate that surrounded the case in the 1980s. This paper argues against the binary understanding of the landmark Shah Bano Case as either a failure or success of Indian secularism. I argue that the case and its aftermath demonstrate the continual nature of Indian secularism and democratic practice, especially laden in the post-Emergency era.

- Restriction End Date: 2029-06-01
Date: 2024-01-01
Creator: Olivia Sewon Choi
Access: Access restricted to the Bowdoin Community
Date: 2024-01-01
Creator: Marcus Gadsden
Access: Open access
- This dissertation examines the existence of racial bias within capital punishment. Since colonial times discriminatory death sentencing has impacted racial minorities, and despite living in a post-colonial epoch, the United States Justice system continues to produce alarming racial disparities. Consequently, both law reviews and social science journals indicate that race remains a significant factor in criminal trials. So, to what extent does racial bias influence capital punishment trials? Given that it does exist, how can it be alleviated? Through a statistical/qualitative analysis of psychological studies, Supreme Court cases, and jury instructions, this dissertation suggests that implicit cognitive bias continues to produce daunting realities in contemporary criminal punishment processes. Notably among juries, traditional judicial procedures have ostensibly triggered implicit bias and psychological intimidation, i.e. jury instructions. Moreover, do long and complicated jury instructions heighten instances of partial judgment? In Racial Bias within Capital Punishment: Instructional Comprehension, I argue that inaccessible jury instructions provide a space where jurors adhere to subtle racial preferences. Consequently, the swaying capacity of juries in capital punishment trials proceeds to arbitrarily produce discrepancies in sentencing rates.

- Embargo End Date: 2028-05-17
Date: 2023-01-01
Creator: Lyn Stephanie Miranda Portillo
Access: Embargoed

Date: 2023-01-01
Creator: Isabella de la Luz Quintana
Access: Access restricted to the Bowdoin Community

- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Andrew YH Chang
Access: Embargoed

- Embargo End Date: 2028-05-18
Date: 2023-01-01
Creator: Annika Moore
Access: Embargoed
Date: 2023-01-01
Creator: Arav Agarwal
Access: Open access
- We begin with the classical study of the Riemann zeta function and Dirichlet L-functions. This includes a full exposition on one of the most useful ways of exploiting their connection with primes, namely, explicit formulae. We then proceed to introduce statistics of low-lying zeros of Dirichlet L-functions, discussing prior results of Fiorilli and Miller (2015) on the 1-level density of Dirichlet L-functions and their achievement in surpassing the prediction of the powerful Ratios Conjecture. Finally, we present our original work partially generalizing these results to the case of Hecke L-functions over imaginary quadratic fields.
Date: 2017-05-01
Creator: Abby Elizabeth Motycka
Access: Open access
- What was the impact of Brown v. Board of Education on the United States and how did pro-segregationists in the South respond? In order to answer this question, I argue three key arguments over the course of three chronological chapters. In chapter one, I argue that segregationists from southern states responded to Brown by fighting to preserve segregation in order to protect a racial hierarchy they believed was essential. This racial hierarchy is magnified in the southern capital of Little Rock, Arkansas, which I argue in chapter two exposed segregationists’ political defiance and poor organization around racial integration of public schools. After a year of integration, analyzed in chapter three, I conclude my chapters by arguing the first year slowed down the segregationist organizations, but did not persuade them that racial integration would improve the “southern way of life.”
Date: 2017-05-01
Creator: Savannah Blake Horton
Access: Open access
- This is What You Want: Stories is a collection of nine stories exploring the role of humor in dark situations. It is a work of fiction.
Date: 2024-01-01
Creator: Jared Lynch
Access: Open access
- The mitochondrial genome has historically been relegated to a neutral genetic marker, but new evidence suggests mitochondrial DNA to be a target for adaptation to environmental stress. The invasive European green crab (Carcinus maenas) exemplifies this in the Gulf of Maine’s hybrid zone, where interbreeding populations exhibit thermal tolerances influenced by mitochondrial genotype. To better understand the mechanism behind this phenomenon, the effect of mitochondrial genotype on mitochondrial activity was tested by measuring mtDNA copy number (mtCN) and the activity of complex I, II, and IV of the electron transport system via high-resolution respirometry. Mitochondria isolated from frozen heart tissue were measured at three temperature points—5°C, 25°C, and 37°C—to represent thermal stresses and a control. It was predicted that cold-adapted haplogroups would exhibit both higher mtCN and increased activity for each complex, either across all temperatures or exclusively at 5°C compared to a warm-adapted haplogroup. Initial comparisons of mitochondria from fresh and frozen tissue at 25°C found lower activity for complex II and IV in frozen extracts, but they continued to be used for convenience. No differences were observed across haplogroups for mtCN or high-resolution respirometry, suggesting that mitochondrial activity does not underlie differences in thermal tolerance. However, temperature greatly influenced activity measurements with complex II and IV exhibiting the highest rates at 37°C while complex I exhibited optimal activity at 25°C. This study represents the first of its kind for C. maenas, providing a foundation for future experiments to continue exploring mitochondria in the context of adaptive evolution.

- Embargo End Date: 2029-05-16
Date: 2024-01-01
Creator: Juliana Keyes Vandermark
Access: Embargoed

- Restriction End Date: 2027-06-01
Date: 2024-01-01
Creator: Oliver Wang
Access: Access restricted to the Bowdoin Community

- Embargo End Date: 2025-05-16
Date: 2024-01-01
Creator: Leopold Felix Spieler
Access: Embargoed
Date: 2025-01-01
Creator: Margaret Broaddus
Access: Open access
- ABSTRACT CHAPTER I: All nervous systems are influenced by circulating hormones, which can modulate neural circuits to produce different outputs from the same set of neurons. Invertebrate models, particularly crustaceans, serve as excellent models for studying neuromodulation because they contain neural circuits that continue to generate fictive activity when dissected out of the animal. The stomatogastric nervous system (STNS) of the Jonah Crab (Cancer borealis) has long been used to study neuromodulation due to its well-characterized circuits. Even in such a compact neural network, little is known about how these circuits are modulated, and this remains a question in all animals, particularly in humans. Here we investigated the modulation of the pyloric circuit by applying bulk hemolymph to the dissected STNS preparation. The hemolymph contains all of the circulating modulators, some of which have known effects on the pyloric rhythm (though many are still unknown). Interestingly, when hemolymph is applied to the isolated STNS, the pyloric rhythm is suppressed. This is surprising given that in vivo the STNS is continually exposed to hemolymph (the STG is situated within an artery, and thus, exposed to circulating hemolymph) and the pyloric rhythm is constitutively active. Therefore, I hypothesized that there are synaptically released neurotransmitters that excite the pyloric rhythm. To test this hypothesis, we applied three different excitatory modulators – proctolin, serotonin, and oxotremorine – separately in the presence of hemolymph. I found that proctolin and oxotremorine restore the pyloric rhythm in the presence of hemolymph. However, serotonin did not consistently overcome the inhibition of hemolymph. ABSTRACT CHAPTER II: A plethora of work has begun to identify how endogenous neural and hormonal modulators interact to influence the pyloric network. Here we examined the modulation of the stomatogastric nervous system (STNS) via two excitatory endogenous modulators CabTRP Ia and corazonin. CabTRP Ia and corazonin both excite the pyloric rhythm, but in distinct ways. Preliminary data by Nusbaum and Christie from 2003 suggested that an initial corazonin application gated a stronger response to subsequent CabTRP Ia when compared the inverse application of these neuromodulators. We sought to validate this gating phenomenon, but found no significant difference between the effects of the first and second applications of CabTRP Ia. Given that these animals are wild caught and surviving in a changing oceanic environment, it is possible that this modulatory effect in the Jonah Crab has changed over the last few decades due to environmentally driven shifts in receptor expression and channel conductances.

Date: 2025-01-01
Creator: Carina Lim-Huang
Access: Access restricted to the Bowdoin Community
Date: 2025-01-01
Creator: Hamda Abdirahman Hussein, Fatima K Kunjo
Access: Open access

Date: 2025-01-01
Creator: Cara Sydney Nova Fields
Access: Access restricted to the Bowdoin Community

Date: 2025-01-01
Creator: Rhys Edwards
Access: Access restricted to the Bowdoin Community
Date: 2025-01-01
Creator: Sujan Garapati
Access: Open access
- Since 2001, Japan has experienced two extended quantitative easing (QE) periods that aimed to address its low growth and deflationary environment. This paper investigates the transmission channels of the country’s QE policies during both periods: QE1 and Abenomics. Investigating three primary QE channels, signaling, inflation, and safety, the analysis identifies a signaling channel with different characteristics during both periods, no inflation channel, and a safety channel with different strengths during both periods. During QE1, event dates signaled low yields on short- and medium-term bonds but not on long-term bonds, suggesting a weak signaling channel. In contrast, under Abenomics, the signaling channel was strong for long-term bonds, reflecting a credible commitment to sustained low interest rates. Event dates in both periods were associated with deflation, so the evidence does not support the presence of an inflation channel. Across both periods, a significant safety channel was present. Investors paid a premium for safe assets that decreased yields as the BOJ purchased bonds, especially during Abenomics. The findings suggest that Abenomics was more successful at decreasing interest rates than QE1. Overall, this paper reveals that QE can effectively lower yields through signaling and safety effects but fails to raise inflation expectations in Japan.

Date: 2025-01-01
Creator: Philip Spyrou
Access: Access restricted to the Bowdoin Community

Date: 2025-01-01
Creator: Aeri Ko
Access: Access restricted to the Bowdoin Community
Date: 2020-01-01
Creator: Dani Paul Hove
Access: Open access
- Comfortable locomotion in VR is an evolving problem. Given the high probability of vestibular-visual disconnect, and subsequent simulator sickness, new users face an uphill battle in adjusting to the technology. While natural locomotion offers the least chance of simulator sickness, the space, economic and accessibility barriers to it limit its effectiveness for a wider audience. Software-enabled locomotion circumvents much of these barriers, but has the greatest need for simulator sickness mitigation. This is especially true for standing VR experiences, where sex-biased differences in mitigation effectiveness are amplified (postural instability due to vection disproportionately affects women). Predictive trails were developed as a shareable Unity module in order to combat some of the gaps in current mitigation methods. Predictive trails use navigation meshes and path finding to plot the user’s available path according to their direction of vection. Some of the more prominent software methods each face distinct problems. Vignetting, while largely effective, restricts user field-of-vision (FoV), which in prolonged scenarios, has been shown to disproportionately lower women’s navigational ability. Virtual noses, while effective without introducing FoV restrictions, requires commercial licensing for use. Early testing of predictive trails proved effective on the principal investigator, but a wider user study - while approved - was unable to be carried out due to circumstances of the global health crisis. While the user study was planned around a seated experience, further study is required into the respective sex-biased effect on a standing VR experience. Additional investigation into performance is also required.