Showing 451 - 500 of 5831 Items

Date: 2012-09-10

Creator: Michael J. Sauer, C. S. Roesler, P. J. Werdell, A. Barnard

Access: Open access

Empirically-based satellite estimates of chlorophyll a [Chl] (e.g. OC3) are an important indicator of phytoplankton biomass. To correctly interpret [Chl] variability, estimates must be accurate and sources of algorithm errors known. While the underlying assumptions of band ratio algorithms such as OC3 have been tacitly hypothesized (i.e. CDOM and phytoplankton absorption covary), the influence of component absorption and scattering on the shape of the algorithm and estimated [Chl] error has yet to be explicitly revealed. We utilized the NOMAD bio-optical data set to examine variations between satellite estimated [Chl] and in situ values. We partitioned the variability into (a) signal contamination and (b) natural phytoplankton variability (variability in chlorophyll-specific phytoplankton absorption). Not surprisingly, the OC3 best-fit curve resulted from a balance between these two different sources of variation confirming the bias by detrital absorption on global scale. Unlike previous descriptions of empirical [Chl] algorithms, our study (a) quantified the mean detrital:phytoplankton absorption as ~1:1in the global NOMAD data set, and (b) removed detrital (CDOM + non-algal particle) absorption in radiative transfer models directly showing that the scale of the remaining variability in the band ratio algorithm was dominated by phytoplankton absorption cross section. © 2012 Optical Society of America.

Date: 2011-01-01

Creator: J. Lichter, M.E.H. Burton, S.L. Close, J.M. Grinvalsky, J., Reblin

Access: Open access

Date: 2010-10-01

Creator: Wayne H. Slade, Emmanuel Boss, Giorgio Dall'olmo, M. Rois Langner, James, Loftin, Michael J. Behrenfeld, Collin Roesler, Toby K. Westberry

Access: Open access

Optical sensors have distinct advantages when used in ocean observatories, autonomous platforms, and on vessels of opportunity, because of their high-frequency measurements, low power consumption, and the numerous established relationships between optical measurements and biogeochemical variables. However, the issues of biofouling and instrument stability over time remain complicating factors when optical instruments are used over periods longer than several days. Here, a method for obtaining calibration-independent measurements of spectral particle absorption and attenuation is presented. Flow-through optical instrumentation is routinely diverted through a large-surface area 0.2-μm cartridge filter, allowing for the calculation of particle optical properties by differencing temporally adjacent filtered and whole water samples. This approach yields measurements that are independent of drift in instrument calibration. The method has advantages not only for coastally moored deployments, but also for applications in optically clear waters where uncertainties in instrument calibration can be a significant part of the signal measured. The differencing technique is demonstrated using WET Labs (Philomath, Oregon) ac-9 and ac-s multi- and hyperspectral absorption and attenuation meters. For the ac-s sensor, a correction scheme is discussed that utilizes the spectral shape of water absorption in the near-infrared to improve the accuracy of temperature and scattering-corrected spectra. Flow-through particulate absorption measurements are compared with discrete filter-pad measurements and are found to agree well (R = 0.77; rmse = 0.0174 m ). © 2010 American Meteorological Society. 2 -1

Date: 2013-04-12

Creator: Jennifer Earl

Access: Open access

For scholars interested in the role of information communication technologies (ICTs) in protest and social movements, the importance of organizations doesn’t appear to be as axiomatic. Work over the past decade researching “Internet activism” has raised fundamental questions about SMOs and their continuing importance to protest: Do organizations play the same role in online protest as they have played in offline protest? Are SMOs as necessary for online movements and protest organizing? What role or functions do SMOs play in online protest? In this article, I address these questions by first surveying social movement research on pre-Internet protest to establish how traditional social movement scholarship understands the role and impact of SMOs. I then compare these expectations to existing work on online protest. In the end, I argue that there are a variety of factors that contribute to the declining necessity of SMOs. Nonetheless, I point to some advantages that SMOs still seem to offer over other forms of organizing. Finally, I discuss the differences between a movement ecology devoid of SMOs versus one that has some level of SMO presence as well as reasons why SMOs might persist, separate and apart from the advantages the organizational form imparts.

Date: 2008-01-01

Creator: Michael M. Franz, Paul Freedman, Ken Goldstein, Travis N. Ridout

Access: Open access

Krasno and Green have argued that political advertising has no impact on voter turnout. We remain unconvinced by their evidence, given concerns about how they measure the advertising environment, how they measure advertising tone, their choice of modeling techniques and the generalizability of their findings. These differences aside, we strongly agree that political advertising does little to undermine voter participation. © 2008 Southern Political Science Association.

Date: 2013-11-01

Creator: Erik J. Nelson, Peter Kareiva, Mary Ruckelshaus, Katie Arkema, Gary, Geller, Evan Girvetz, Dave Goodrich, Virginia Matzek, Malin Pinsky

Access: Open access

Climate change alters the functions of ecological systems. As a result, the provision of ecosystem services and the well-being of people that rely on these services are being modified. Climate models portend continued warming and more frequent extreme weather events across the US. Such weather-related disturbances will place a premium on the ecosystem services that people rely on. We discuss some of the observed and anticipated impacts of climate change on ecosystem service provision and livelihoods in the US. We also highlight promising adaptive measures. The challenge will be choosing which adaptive strategies to implement, given limited resources and time. We suggest using dynamic balance sheets or accounts of natural capital and natural assets to prioritize and evaluate national and regional adaptation strategies that involve ecosystem services. © The Ecological Society of America.

Date: 2013-03-10

Creator: Yao Tang, Daniel Shapiro, Miaojun Wang, Weiying Zhang

Access: Open access

We investigate the degree to which corporate governance and ownership affects the innovation performance of firms in China with a particular focus on privately owned small and medium enterprises (SMEs). We hypothesize that (1) board-related governance measures will enhance innovation because they improve monitoring and provide access to necessary resources; (2) ownership concentration initially facilitates innovation because large shareholders are more likely to commit to the long-term nature of innovation, and have the incentive to monitor managers whose time horizon may be shorter; however we argue that these effects weaken as large shareholders becomes entrenched at higher levels of concentration; and (3) hiring an external CEO will enhance innovation both by ensuring professional management of the company, and by alleviating the entrenchment possibilities associated with large shareholders. These hypotheses are tested using a unique sample of 370 mostly private and relatively small Chinese firms in Zhejiang province, for the period 2004 to 2006. The results suggest that for this sample, corporate governance and ownership affect innovation activity when measured by patenting activity, but not when measured by new product sales.

Date: 1879-01-01

Access: Open access

Date: 1879-01-01

Access: Open access

Date: 1895-01-01

Access: Open access

Date: 2008-04-01

Creator: Thomas Pietraho

Access: Open access

We consider two families of equivalence classes in the Weyl groups of type B n which are suggested by the study of left cells in unequal parameter Iwahori-Hecke algebras. Both families are indexed by a non-negative integer r. It has been shown that the first family coincides with left cells corresponding to the equal parameter Iwahori-Hecke algebra when r=0; the equivalence classes in the second family agree with left cells corresponding to a special class of choices of unequal parameters when r is sufficiently large. Our main result shows that the two families of equivalence classes coincide, suggesting the structure of left cells for remaining choices of the Iwahori-Hecke algebra parameters. © 2007 Springer Science+Business Media, LLC.

Date: 1915-01-01

Access: Open access

Date: 1964-01-01

Access: Open access

Catalog of an exhibition held at the Bowdoin College Museum of Art, 1964.

Date: 2017-09-01

Creator: Christina A. Cuomo, Terrance Shea, Bo Yang, Reeta Rao, Anja, Forche

Access: Open access

Candida krusei is a diploid, heterozygous yeast that is an opportunistic fungal pathogen in immunocompromised patients. This species also is utilized for fermenting cocoa beans during chocolate production. One major concern in the clinical setting is the innate resistance of this species to the most commonly used antifungal drug fluconazole. Here, we report a high-quality genome sequence and assembly for the first clinical isolate of C. krusei, strain 81-B-5, into 11 scaffolds generated with PacBio sequencing technology. Gene annotation and comparative analysis revealed a unique profile of transporters that could play a role in drug resistance or adaptation to different environments. In addition, we show that, while 82% of the genome is highly heterozygous, a 2.0 Mb region of the largest scaffold has undergone loss of heterozygosity. This genome will serve as a reference for further genetic studies of this pathogen.

Date: 2018-02-15

Creator: Sophie Bérubé, Tara Palnitkar, Jennifer Taback

Access: Open access

We show that the higher rank lamplighter groups, or Diestel–Leader groups Γd(q) for d≥3, are graph automatic. This introduces a new family of graph automatic groups which are not automatic.

Date: 2009-07-01

Creator: Anja Forche, P. T. Magee, Anna Selmecki, Judith Berman, Georgiana, May

Access: Open access

The mechanisms and rates by which genotypic and phenotypic variation is generated in opportunistic, eukaryotic pathogens during growth in hosts are not well understood. We evaluated genomewide genetic and phenotypic evolution in Candida albicans, an opportunistic fungal pathogen of humans, during passage through a mouse host (in vivo) and during propagation in liquid culture (in vitro). We found slower population growth and higher rates of chromosome-level genetic variation in populations passaged in vivo relative to those grown in vitro. Interestingly, the distribution of long-range loss of heterozygosity (LOH) and chromosome rearrangement events across the genome differed for the two growth environments, while rates of short-range LOH were comparable for in vivo and in vitro populations. Further, for the in vivo populations, there was a positive correlation of cells demonstrating genetic alterations and variation in colony growth and morphology. For in vitro populations, no variation in growth phenotypes was detected. Together, our results demonstrate that passage through a living host leads to slower growth and higher rates of genomic and phenotypic variation compared to in vitro populations. Results suggest that the dynamics of population growth and genomewide rearrangement contribute to the maintenance of a commensal and opportunistic life history of C. albicans. Copyright © 2009 by the Genetics Society of America.

Date: 2009-06-01

Creator: Thomas Pietraho

Access: Open access

C. Bonnafé, M. Geck, L. Iancu, and T. Lam have conjectured a description of Kazhdan-Lusztig cells in unequal parameter Hecke algebras of type B which is based on domino tableaux of arbitrary rank. In the integer case, this generalizes the work of D. Garfinkle. We adapt her methods and construct a family of operators which generate the equivalence classes on pairs of arbitrary rank domino tableaux described in the above conjecture. © 2008 Springer Science+Business Media, LLC.

Date: 2000-01-01

Access: Open access

Includes an essay by the curator Allison Ferris.

Date: 2019-10-01

Creator: Rachel Augustine Potter, Andrew Rudalevige, Sharece Thrower, Adam L. Warber

Access: Open access

From campaign rhetoric to tweets, President Trump has positioned himself as disrupter in chief, often pointing to administrative action as the avenue by which he is leaving a lasting mark. However, research on the administrative presidency begins with the premise that all presidents face incentives to use administrative tools to gain substantive or political traction. If, as this article suggests, Trump's institutional standing differs little from his recent predecessors, then how much of the Trump presidency represents a change from past norms and practices' How much represents continuity, or the perennial dynamics of a far-from-omnipotent executive in an ongoing world of separate institutions sharing powers (Neustadt 1990, 29)' To answer this, we tracked presidential directives and regulatory policy during Trump's first year in office. We found evidence of continuity, indicating that in its use of administrative tactics to shape policy, the Trump White House largely falls in line with recent presidencies.

Date: 2009-01-15

Creator: C. Chong, R. Carretero-González, B. A. Malomed, P. G. Kevrekidis

Access: Open access

We study the existence, stability, and mobility of fundamental discrete solitons in two- and three-dimensional nonlinear Schrödinger lattices with a combination of cubic self-focusing and quintic self-defocusing onsite nonlinearities. Several species of stationary solutions are constructed, and bifurcations linking their families are investigated using parameter continuation starting from the anti-continuum limit, and also with the help of a variational approximation. In particular, a species of hybrid solitons, intermediate between the site- and bond-centered types of the localized states (with no counterpart in the 1D model), is analyzed in 2D and 3D lattices. We also discuss the mobility of multi-dimensional discrete solitons that can be set in motion by lending them kinetic energy exceeding the appropriately defined Peierls-Nabarro barrier; however, they eventually come to a halt, due to radiation loss. © 2008 Elsevier B.V. All rights reserved.

Date: 2016-11-01

Creator: Robert W. Brown, Stephen G. Naculich

Access: Open access

Tree-level n-point gauge-theory amplitudes with n − 2k gluons and k pairs of (massless or massive) particles in the fundamental (or other) representation of the gauge group are invariant under a set of symmetries that act as momentum-dependent shifts on the color factors in the cubic decomposition of the amplitude. These symmetries lead to gauge-invariant constraints on the kinematic numerators. They also directly imply the BCJ relations among the Melia-basis primitive amplitudes previously obtained by Johansson and Ochirov.

Date: 2021-12-01

Creator: Hannah E. Reese, W. Alan Brown, Berta J. Summers, Jin Shin, Grace, Wheeler, Sabine Wilhelm

Access: Open access

Abstract: Background: Preliminary research suggests that a mindfulness-based treatment approach may be beneficial for adults with tic disorders. In the present study, we report on the feasibility, acceptability, safety, and symptomatic effect of a novel online mindfulness-based group intervention for adults with Tourette syndrome or persistent tic disorder. Data from this study will directly inform the conduct of a funded randomized controlled trial comparing the efficacy of this intervention to another active psychological intervention. Methods: One cohort of adults with Tourette syndrome participated in an 8-week online mindfulness-based group intervention. Measures of feasibility, acceptability, and safety were administered throughout and at posttreatment. Self-reported measures of mindfulness and clinician-rated measures of tic severity and impairment were administered at baseline and posttreatment. Results: Data on refusal, dropout rate, attendance, participant satisfaction, and safety suggest that this is a feasible and acceptable intervention. However, participant adherence to home practice was lower than anticipated. Mindfulness, tic severity, and tic-related impairment only modestly improved from baseline to posttreatment. Qualitative analysis of participant feedback revealed aspects of the intervention that were most helpful and also areas for improvement. Conclusions: Data suggest that although this is a feasible and acceptable intervention, it should be modified to enhance participant adherence, more successfully engage the target mechanism, and optimize outcomes. Trial registration: Clinicaltrials.gov registration #NCT03525626. Registered on 24 April 2018

Date: 2014-01-01

Creator: A. Leonard, C. Chong, P. G. Kevrekidis, C. Daraio

Access: Open access

This study describes the dynamic response of a two-dimensional hexagonal packing of uncompressed stainless steel spheres excited by localized impulsive loadings. The dynamics of the system are modeled using the Hertzian normal contact law. After the initial impact strikes the system, a characteristic wave structure emerges and continuously decays as it propagates through the lattice. Using an extension of the binary collision approximation for one-dimensional chains, we predict its decay rate, which compares well with numerical simulations and experimental data. While the hexagonal lattice does not support constant speed traveling waves, we provide scaling relations that characterize the directional power law decay of the wave velocity for various angles of impact. Lastly, we discuss the effects of weak disorder on the directional amplitude decay rates. © 2014 The Author(s).

Date: 2019-05-01

Creator: Sydney Smith

Access: Open access

Date: 1976-01-01

Creator: Gordon EKershaw, Peter R. Mooz

Access: Open access

"An exhibition held at the Bowdoin College Museum of Art, Brunswick, Maine, May 28 through September 12, 1976."

Date: 2018-04-21

Creator: Maria Tysiachniouk, Svetlana Tulaeva, Laura A. Henry

Access: Open access

This essay analyses how the ‘foreign agent’ law has been interpreted and implemented by the Russian authorities and examines diverse NGO survival strategies in response to the ‘foreign agent’ label. The foreign agent law has disrupted and transformed resource mobilisation strategies and transnational NGO networks. Based on qualitative research on environmental NGOs, we offer a typology of NGO responses to the foreign agent law, providing examples to show how the organisations attempt to ensure their survival.

Date: 2019-01-01

Creator: Evalyn Mackenzie

Access: Open access

Central Pattern Generators (CPGs) are neural networks that produce steady, rhythmic patterned outputs that activate particular muscles and consequently create recurrent rhythmic movements. The cardiac ganglion (CG) of the American lobster (Homarus americanus) is a useful model system for the study of CPGs. Neuropeptides modulate cardiac contractions driven by the CG in H. americanus and accordingly elicit a range of effects. Post-translational modifications such as amidation can impact function of a peptide neuromodulator. C-type allatostatins (AST-Cs) are a group of neuropeptides that modulate the cardiac neuromuscular system of H. americanus. The objective of this study was to determine what structural aspects of the peptides were responsible for the similarity in responses elicited by AST-C I and AST-C III and the difference in responses evoked by AST-C II in comparison. AST-C I and AST-C III are not C-terminally amidated, whereas AST-C II is C-terminally amidated. We first hypothesized that amidated AST-C peptides would evoke similar responses to one another in contraction amplitude and frequency. Our second hypothesis was that exchanging the amino acids alanine and tyrosine at a specific location in AST-C II and AST-C III would affect the conformation of the peptide, and consequently impact peptide binding and elicit different effects. In contrast to our predictions, we did not see similar responses evoked by all amidated or all non-amidated peptides among lobsters. In support of our second hypothesis, there was a significant difference in percent change in contraction amplitude elicited among AST-C II Y, AST-C II and AST-C III.

Date: 2015-12-29

Creator: Michael F. Palopoli, Daniel J. Fergus, Samuel Minot, Dorothy T. Pei, W. Brian, Simison, Iria Fernandez-Silva, Megan S. Thoemmes, Robert R. Dunn, Michelle Trautwein

Access: Open access

Microscopic mites of the genus Demodex live within the hair follicles of mammals and are ubiquitous symbionts of humans, but little molecular work has been done to understand their genetic diversity or transmission. Here we sampled mite DNA from 70 human hosts of diverse geographic ancestries and analyzed 241 sequences from the mitochondrial genome of the species Demodex folliculorum. Phylogenetic analyses recovered multiple deep lineages including a globally distributed lineage common among hosts of European ancestry and three lineages that primarily include hosts of Asian, African, and Latin American ancestry. To a great extent, the ancestral geography of hosts predicted the lineages of mites found on them; 27% of the total molecular variance segregated according to the regional ancestries of hosts. We found that D. folliculorum populations are stable on an individual over the course of years and that some Asian and African American hosts maintain specific mite lineages over the course of years or generations outside their geographic region of birth or ancestry. D. folliculorum haplotypes were much more likely to be shared within families and between spouses than between unrelated individuals, indicating that transmission requires close contact. Dating analyses indicated that D. folliculorum origins may predate modern humans. Overall, D. folliculorum evolution reflects ancient human population divergences, is consistent with an out-of-Africa dispersal hypothesis, and presents an excellent model system for further understanding the history of human movement.

Date: 1883-01-01

Access: Open access

Date: 2017-07-01

Creator: Philip Camill, Charles E. Umbanhowar, Christoph Geiss, Mark B. Edlund, Will O., Hobbs, Allison Dupont, Catherine Doyle-Capitman, Matthew Ramos

Access: Open access

Small peat-forming ecosystems in arctic landscapes may play a significant role in the regional biogeochemistry of high-latitude systems, yet they are understudied compared to arctic uplands and other major peat-forming regions of the North. We present a new data set of 25 radiocarbon-dated permafrost peat cores sampled around eight low arctic lake sites in northern Manitoba (Canada) to examine the timing of peat initiation and controls on peat accumulation throughout the Holocene. We used macrofossils and charcoal to characterize changes in the plant community and fire, and we explored potential impacts of these local factors, as well as regional climatic change, on rates of C accumulation and C stocks. Peat initiation was variable across and within sites, suggesting the influence of local topography, but 56% of the cores initiated after 3000 B.P. Most cores initiated and remained as drier bog hummock communities, with few vegetation transitions in this landscape. C accumulation was relatively slow and did not appear to be correlated with Holocene-scale climatic variability, but C stocks in this landscape were substantial (mean = 45.4 kg C m ), potentially accounting for 13.2 Pg C in the Taiga Shield ecozone. To the extent that small peat-forming systems are underrepresented in peatland mapping, soil organic carbon (SOC) stocks may be underestimated in arctic regions. Mean fire severity appeared to be negatively correlated with C accumulation rates. Initiation and accumulation of soil C may respond to both regional and local factors, and substantial lowland soil C stocks have the potential for biogeochemical impacts on adjacent aquatic ecosystems. −2

Date: 2019-05-01

Creator: Samuel Robert Kenney

Access: Open access

Much of the discourse surrounding African immigration to Maine has centered on the provision of public services that facilitate community development and integration. This project investigates different types of leadership strategies employed by African individuals in Maine that advance community objectives. When African immigrant leaders are empowered to affect public policy, they re-frame traditional conceptions of aid-dependency and vulnerability commonly applied to African immigrants in media and popular culture. Through leadership in nonprofit and civic spheres, African immigrant community leaders translate grassroots connectivity with informal networks into meaningful influence in the realm of public policy. This project focuses on the evolution of community leadership in Maine’s Somali community, the network of immigrant-serving organizations that provide specialized public services across the state, and the capacity of one organization in particular, the Maine Immigrants’ Rights Coalition (MIRC) to ensure accurate representation of policy initiatives to civic officials for individuals unable to participate in the electoral process. This project evaluates the political utility of ‘lived experience’ as a component of diversity in the realm of public policy.

Date: 1995-01-01

Creator: Eric Chown, Stephen Kaplan, David Kortenkamp

Access: Open access

An integrated representation of large-scale space, or cognitive map, colled PLAN, is presented that attempts to address a broader spectrum of issues than has been previously attempted in a single model. Rather than examining way-finding as a process separate from the rest of cognition, one or the fundamental goals of this work is to examine how the wayfinding process is integrated into general cognition. One result of this approach is that the model is "heads-up," or scene-based, because it takes advantage of the properties of the human visual system and, particularly, the visual system's split into two pathways. The emphasis on the human location or "where" system is new to cognitive mapping and is port of an attempt to synthesize prototype theory, associative networks and location together in a connectionist system. Not all of PLAN is new, however. Many of its parts have analogues in one or another preexisting theory. What makes PLAN unique is integrating the various components into a coherent whole, and the capacity of this resulting system to speak to a wide range of constraints. Our approach emphasizes adaptiveness; thus, our focus on such issues as ease of use and efficiency of learning. The result is a model that has a stronger relationship both to the environment, and to the ways that humans interact with it, compared with previous models. The resulting model is examined in some detail and compared to other systems. © 1995.

Date: 2011-01-01

Creator: David J. Lewis, Andrew J. Plantinga, Erik Nelson, Stephen Polasky

Access: Open access

Habitat loss is a primary cause of loss of biodiversity but conserving habitat for species presents challenges. Land parcels differ in their ability to produce returns for landowners and landowners may have private information about the value of the land to them. Land parcels also differ in the type and quality of habitat and the spatial pattern of land use across multiple landowners is important for determining the conservation value of parcels. This paper analyzes the relative efficiency of simple voluntary incentive-based policies in achieving biodiversity conservation objectives. This topic is important not just for biodiversity conservation but for any effort to provide a public good requiring coordination across multiple decision-makers who have some degree of private information. We develop a method that integrates spatially explicit data, an econometric model of private land-use decisions, landscape simulations, a biological model of biodiversity as a function of landscape pattern, and an algorithm that estimates the set of efficient solutions. These methods allow us to simulate landowner responses to policies, measure the consequences of these decisions for biodiversity conservation, and compare these outcomes to efficient outcomes to show the relative efficiency of various policy approaches. We find substantial differences in biodiversity conservation scores generated by simple voluntary incentive-based policies and efficient solutions. The performance of incentive-based policies is particularly poor at low levels of the conservation budget where spatial fragmentation of conserved parcels is a large concern. Performance can be improved by encouraging agglomeration of conserved habitat and by incorporating basic biological information, such as that on rare habitats, into the selection criteria. © 2010 Elsevier B.V.

Date: 1973-01-01

Access: Open access

Exhibition held August 17-September 20, 1973 in The Boyd Art Gallery, Bowdoin College Museum of Art, Brunswick, Maine.

Date: 2016-09-01

Creator: Robert Morrison

Access: Open access

“Science and Orthodox Christianity: An Overview” is an ambitious survey that reminds scholars of science in Islamic societies that the conversation between Islam and science is really a conversation between Islam and science in different contexts and that conversations between Islam and science can be found with less renowned scientific developments such as prophetic medicine. This response points out parallels in how Greek Orthodox and Ottoman Muslim scholars mediated new developments in Western European science and in how both Greek Orthodox and some Ottoman Muslim scholars propounded a mathematical humanism. Finally, it argues that the account of post-1453 scientific exchange is more complex than “Science and Orthodox Christianity” intimates. At the least, if there was no scholarly exchange between Greek Orthodox Christians, on the one hand, and, on the other hand, Muslims and Jews—who, in turn, enjoyed scholarly exchange with the West well after 1453—there are clearly two different Easts.

Date: 2016-01-25

Creator: C. Chong, P. G. Kevrekidis, M. J. Ablowitz, Yi Ping Ma

Access: Open access

Linear and nonlinear mechanisms for conical wave propagation in two-dimensional lattices are explored in the realm of phononic crystals. As a prototypical example, a statically compressed granular lattice of spherical particles arranged in a hexagonal packing configuration is analyzed. Upon identifying the dispersion relation of the underlying linear problem, the resulting diffraction properties are considered. Analysis both via a heuristic argument for the linear propagation of a wave packet and via asymptotic analysis leading to the derivation of a Dirac system suggests the occurrence of conical diffraction. This analysis is valid for strong precompression, i.e., near the linear regime. For weak precompression, conical wave propagation is still possible, but the resulting expanding circular wave front is of a nonoscillatory nature, resulting from the complex interplay among the discreteness, nonlinearity, and geometry of the packing. The transition between these two types of propagation is explored.

Date: 2019-05-01

Creator: Gina Fickera

Access: Access restricted to the Bowdoin Community

Date: 2004-10-01

Creator: William R. Jackman, Bruce W. Draper, David W. Stock

Access: Open access

We have investigated fibroblast growth factor (FGF) signaling during the development of the zebrafish pharyngeal dentition with the goal of uncovering novel roles for FGFs in tooth development as well as phylogenetic and topographic diversity in the tooth developmental pathway. We found that the tooth-related expression of several zebrafish genes is similar to that of their mouse orthologs, including both epithelial and mesenchymal markers. Additionally, significant differences in gene expression between zebrafish and mouse teeth are indicated by the apparent lack of fgf8 and pax9 expression in zebrafish tooth germs. FGF receptor inhibition with SU5402 at 32 h blocked dental epithelial morphogenesis and tooth mineralization. While the pharyngeal epithelium remained intact as judged by normal pitx2 expression, not only was the mesenchymal expression of lhx6 and lhx7 eliminated as expected from mouse studies, but the epithelial expression of dlx2a, dlx2b, fgf3, and fgf4 was as well. This latter result provides novel evidence that the dental epithelium is a target of FGF signaling. However, the failure of SU5402 to block localized expression of pitx2 suggests that the earliest steps of tooth initiation are FGF-independent. Investigations of specific FGF ligands with morpholino antisense oligonucleotides revealed only a mild tooth shape phenotype following fgf4 knockdown, while fgf8 inhibition revealed only a subtle down-regulation of dental dlx2b expression with no apparent effect on tooth morphology. Our results suggest redundant FGF signals target the dental epithelium and together are required for dental morphogenesis. Further work will be required to elucidate the nature of these signals, particularly with respect to their origins and whether they act through the mesenchyme. © 2004 Elsevier Inc. All rights reserved.

Date: 2021-01-01

Creator: Anonymous

Access: Open access

This is a response to the Documenting Bowdoin & COVID-19 Reflections Questionnaire. The questionnaire was created in March 2021 by staff of Bowdoin's George J. Mitchell Department of Special Collections & Archives. Author is class of 2024.

Date: 2014-01-01

Creator: Richard J. Bennett, Anja Forche, Judith Berman

Access: Open access

Human fungal pathogens can exist in a variety of ploidy states, including euploid and aneuploid forms. Ploidy change has a major impact on phenotypic properties, including the regulation of interactions with the human host. In addition, the rapid emergence of drug-resistant isolates is often associated with the formation of specific supernumerary chromosomes. Pathogens such as Candida albicans and Cryptococcus neoformans appear particularly well adapted for propagation in multiple ploidy states with novel pathways driving ploidy variation. In both species, heterozygous cells also readily undergo loss of heterozygosity (LOH), leading to additional phenotypic changes such as altered drug resistance. Here, we examine the sexual and parasexual cycles that drive ploidy variation in human fungal pathogens and discuss ploidy and LOH events with respect to their far-reaching roles in fungal adaptation and pathogenesis.

Date: 2019-01-01

Creator: Katherine Tian, Rachel E. Henderson, Reyna Parker, Alexia Brown, Justine E., Johnson, Jack R. Bateman

Access: Open access

For many genes, proper gene expression requires coordinated and dynamic interactions between multiple regulatory elements, each of which can either promote or silence transcription. In Drosophila, the complexity of the regulatory landscape is further complicated by the tight physical pairing of homologous chromosomes, which can permit regulatory elements to interact in trans, a phenomenon known as transvection. To better understand how gene expression can be programmed through cis- and trans-regulatory interactions, we analyzed transvection effects for a collection of alleles of the eyes absent (eya) gene. We find that trans-activation of a promoter by the eya eye-specific enhancers is broadly supported in many allelic backgrounds, and that the availability of an enhancer to act in trans can be predicted based on the molecular lesion of an eya allele. Furthermore, by manipulating promoter availability in cis and in trans, we demonstrate that the eye-specific enhancers of eya show plasticity in their promoter preference between two different transcriptional start sites, which depends on promoter competition between the two potential targets. Finally, we show that certain alleles of eya demonstrate pairing-sensitive silencing resulting from trans-interactions between Polycomb Response Elements (PREs), and genetic and genomic data support a general role for PcG proteins in mediating transcriptional silencing at eya. Overall, our data highlight how eya gene regulation relies upon a complex but plastic interplay between multiple enhancers, promoters, and PREs.

Date: 2012-04-01

Creator: V. C. Radeloff, E. Nelson, A. J. Plantinga, D. J. Lewis, D., Helmers, J. J. Lawler, J. C. Withey, F. Beaudry, S. Martinuzzi

Access: Open access

Land-use change significantly contributes to biodiversity loss, invasive species spread, changes in biogeochemical cycles, and the loss of ecosystem services. Planning for a sustainable future requires a thorough understanding of expected land use at the fine spatial scales relevant for modeling many ecological processes and at dimensions appropriate for regional or national-level policy making. Our goal was to construct and parameterize an econometric model of land-use change to project future land use to the year 2051 at a fine spatial scale across the conterminous United States under several alternative land-use policy scenarios. We parameterized the econometric model of land-use change with the National Resource Inventory (NRI) 1992 and 1997 land-use data for 844 000 sample points. Land-use transitions were estimated for five land-use classes (cropland, pasture, range, forest, and urban). We predicted land-use change under four scenarios: business-as-usual, afforestation, removal of agricultural subsidies, and increased urban rents. Our results for the business-as-usual scenario showed widespread changes in land use, affecting 36% of the land area of the conterminous United States, with large increases in urban land (79%) and forest (7%), and declines in cropland (\-16%) and pasture (\-13%). Areas with particularly high rates of land-use change included the larger Chicago area, parts of the Pacific Northwest, and the Central Valley of California. However, while land-use change was substantial, differences in results among the four scenarios were relatively minor. The only scenario that was markedly different was the afforestation scenario, which resulted in an increase of forest area that was twice as high as the business-as-usual scenario. Land-use policies can affect trends, but only so much. The basic economic and demographic factors shaping land-use changes in the United States are powerful, and even fairly dramatic policy changes, showed only moderate deviations from the business-as-usual scenario. Given the magnitude of predicted land-use change, any attempts to identify a sustainable future or to predict the effects of climate change will have to take likely land-use changes into account. Econometric models that can simulate land-use change for broad areas with fine resolution are necessary to predict trends in ecosystem service provision and biodiversity persistence. © 2012 by the Ecological Society of America.

Date: 1984-01-01

Creator: William H. Barker

Access: Open access

Date: 2013-02-07

Creator: Meleah A. Hickman, Guisheng Zeng, Anja Forche, Matthew P. Hirakawa, Darren, Abbey, Benjamin D. Harrison, Yan Ming Wang, Ching Hua Su, Richard J. Bennett, Yue Wang, Judith Berman

Access: Open access

Candida albicans, the most prevalent human fungal pathogen, is considered to be an obligate diploid that carries recessive lethal mutations throughout the genome. Here we demonstrate that C. albicans has a viable haploid state that can be derived from diploid cells under in vitro and in vivo conditions, and that seems to arise through a concerted chromosome loss mechanism. Haploids undergo morphogenetic changes like those of diploids, including the yeast-hyphal transition, chlamydospore formation and a white-opaque switch that facilitates mating. Haploid opaque cells of opposite mating type mate efficiently to regenerate the diploid form, restoring heterozygosity and fitness. Homozygous diploids arise spontaneously by auto-diploidization, and both haploids and auto-diploids show a similar reduction in fitness, in vitro and in vivo, relative to heterozygous diploids, indicating that homozygous cell types are transient in mixed populations. Finally, we constructed stable haploid strains with multiple auxotrophies that will facilitate molecular and genetic analyses of this important pathogen. © 2013 Macmillan Publishers Limited. All rights reserved.

Date: 2019-06-01

Creator: Robert T. Todd, Tyler D. Wikoff, Anja Forche, Anna Selmecki

Access: Open access

Genome rearrangements resulting in copy number variation (CNV) and loss of heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and promote rapid adaptation of fungi to novel environments. In the human fungal pathogen Candida albicans, CNV and LOH confer increased virulence and antifungal drug resistance, yet the mechanisms driving these rearrangements are not completely understood. Here, we unveil an extensive array of long repeat sequences (65–6499 bp) that are associated with CNV, LOH, and chromosomal inversions. Many of these long repeat sequences are uncharacterized and encompass one or more coding sequences that are actively transcribed. Repeats associated with genome rearrangements are predominantly inverted and separated by up to ~1.6 Mb, an extraordinary distance for homology-based DNA repair/recombination in yeast. These repeat sequences are a significant source of genome plasticity across diverse strain backgrounds including clinical, environmental, and experimentally evolved isolates, and represent previously uncharacterized variation in the reference genome.

Date: 2018-01-01

Creator: P. Jeremy Werdell, Lachlan I.W. McKinna, Emmanuel Boss, Steven G. Ackleson, Susanne E., Craig, Watson W. Gregg, Zhongping Lee, Stéphane Maritorena, Collin S. Roesler, Cécile S. Rousseaux, Dariusz Stramski, James M. Sullivan, Michael S. Twardowski, Maria Tzortziou, Xiaodong Zhang

Access: Open access

Ocean color measured from satellites provides daily global, synoptic views of spectral water-leaving reflectances that can be used to generate estimates of marine inherent optical properties (IOPs). These reflectances, namely the ratio of spectral upwelled radiances to spectral downwelled irradiances, describe the light exiting a water mass that defines its color. IOPs are the spectral absorption and scattering characteristics of ocean water and its dissolved and particulate constituents. Because of their dependence on the concentration and composition of marine constituents, IOPs can be used to describe the contents of the upper ocean mixed layer. This information is critical to further our scientific understanding of biogeochemical oceanic processes, such as organic carbon production and export, phytoplankton dynamics, and responses to climatic disturbances. Given their importance, the international ocean color community has invested significant effort in improving the quality of satellite-derived IOP products, both regionally and globally. Recognizing the current influx of data products into the community and the need to improve current algorithms in anticipation of new satellite instruments (e.g., the global, hyperspectral spectroradiometer of the NASA Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission), we present a synopsis of the current state of the art in the retrieval of these core optical properties. Contemporary approaches for obtaining IOPs from satellite ocean color are reviewed and, for clarity, separated based their inversion methodology or the type of IOPs sought. Summaries of known uncertainties associated with each approach are provided, as well as common performance metrics used to evaluate them. We discuss current knowledge gaps and make recommendations for future investment for upcoming missions whose instrument characteristics diverge sufficiently from heritage and existing sensors to warrant reassessing current approaches.

Date: 2014-01-01

Creator: David A Collings

Access: Open access

This book argues that climate change has a devastating effect on how we think about the future. Once several positive feedback loops in Earth’s dynamic systems, such as the melting of the Arctic icecap or the drying of the Amazon, cross the point of no return, the biosphere is likely to undergo severe and irreversible warming. Nearly everything we do is premised on the assumption that the world we know will endure into the future and provide a sustaining context for our activities. But today the future of a viable biosphere, and thus the purpose of our present activities, is put into question. A disappearing future leads to a broken present, a strange incoherence in the feel of everyday life. We thus face the unprecedented challenge of salvaging a basis for our lives today. That basis, this book argues, may be found in our capacity to assume an infinite responsibility for ecological disaster and, like the biblical Job, to respond with awe to the alien voice that speaks from the whirlwind. By owning disaster and accepting our small place within the inhuman forces of the biosphere, we may discover how to live with responsibility and serenity whatever may come. (Publisher's Description) Freely available online at https://quod.lib.umich.edu/o/ohp/12832550.0001.001.

Date: 2021-12-01

Creator: Gonca Senel, Mark L.J. Wright

Access: Open access

Recent work has found that countries with older populations face steeper yield curves and issue shorter maturity debt than do younger countries. We reexamine these findings using a new database of public debt maturity and yields for OECD countries. We first show that the behavior of eurozone countries in the pre-euro period drives these results. Next, including more recent data from the post-euro period, we show that the relationship between population age, maturity, and yield curve slopes disappears. This finding is robust to excluding high-credit-risk countries. Last, we show that these patterns reemerge after the European debt crisis, suggesting that eurozone capital markets have resegmented.

Date: 2017-03-06

Creator: Amitai Abramovitch, Lauren S. Hallion, Hannah E. Reese, Douglas W. Woods, Alan, Peterson, John T. Walkup, John Piacentini, Lawrence Scahill, Thilo Deckersbach, Sabine Wilhelm

Access: Open access

Tourette's disorder (TS) and chronic tic disorder (CTD) are neurodevelopmental disorders characterized by involuntary vocal and motor tics. Consequently, TS/CTD have been conceptualized as disorders of cognitive and motor inhibitory control. However, most neurocognitive studies have found comparable or superior inhibitory capacity among individuals with TS/CTD relative to healthy controls. These findings have led to the hypothesis that individuals with TS/CTD develop increased inhibitory control due to the constant need to inhibit tics. However, the role of cognitive control in TS/CTD is not yet understood, particularly in adults. To examine the role of inhibitory control in TS/CTD, the present study investigated this association by assessing the relationship between inhibitory control and treatment response in a large sample of adults with TS/CTD. As part of a large randomized trial comparing behavior therapy versus supportive psychotherapy for TS/CTD, a battery of tests, including tests of inhibitory control was administered to 122 adults with TS/CTD at baseline. We assessed the association between neuropsychological test performance and change in symptom severity, as well as compared the performance of treatment responders and non-responders as defined by the Clinical Global Impression Scale. Results indicated that change in symptoms, and treatment response were not associated with neuropsychological performance on tests of inhibitory control, intellectual ability, or motor function, regardless of type of treatment. The finding that significant change in symptom severity of TS/CTD patients is not associated with impairment or change in inhibitory control regardless of treatment type suggests that inhibitory control may not be a clinically relevant facet of these disorders in adults.

Date: 2004-06-01

Creator: Melanie Legrand, Paul Lephart, Anja Forche, Frank Michael C. Mueller, T., Walsh, P. T. Magee, Beatrice B. Magee

Access: Open access

One hundred and twenty Candida albicans clinical isolates from the late 1980s and early 1990s were examined for homosygosity at the MTL locus. Of these, 108 were heterozygous (MTLa/MTLα), whereas seven were MTLa and five were MTLα. Five of the homozygous isolates were able to switch to the opaque cell morphology, while opaque cells were not detectable among the remaining seven. Nevertheless, all but one of the isolates homozygous at the MTL locus were shown to mate and to yield cells containing markers from both parents; the non-mater was found to have a frameshift in the MTLα1 gene. In contrast to Saccharomyces cerevisiae, C. albicans homozygotes with no active MTL allele failed to mate rather than mating as a cells. There was no correlation between homoxygosity and fluconazole resistance, mating and fluconazole resistance or switching and fluconazole resistance, in part because most of the strains were isolated before the widespread use of this antifungal agent, and only three were in fact drug resistant Ten of the 12 homozygotes had rearranged karyotypes involving one or more homologue of chromosomes 4, 5, 6 and 7. We suggest that karyotypic rearrangement, drug resistance and homozygosity come about as the result of induction of hyperrecombination during the infection process; hence, they tend to occur together, but each is the independent result of the same event. Furthermore, as clinical strains can mate and form tetraploids, mating and marker exchange are likely to be a significant part of the life cycle of C. albicans in vivo.