Showing 1371 - 1380 of 5831 Items
Assessment and comparison of putative amine receptor complement/diversity in the brain and eyestalk ganglia of the lobster, Homarus americanus
Date: 2020-06-01
Creator: Andrew E. Christie, J. Joe Hull, Patsy S. Dickinson
Access: Open access
- In decapods, dopamine, octopamine, serotonin, and histamine function as locally released/hormonally delivered modulators of physiology/behavior. Although the functional roles played by amines in decapods have been examined extensively, little is known about the identity/diversity of their amine receptors. Recently, a Homarus americanus mixed nervous system transcriptome was used to identify putative neuronal amine receptors in this species. While many receptors were identified, some were fragmentary, and no evidence of splice/other variants was found. Here, the previously predicted proteins were used to search brain- and eyestalk ganglia-specific transcriptomes to assess/compare amine receptor complements in these portions of the lobster nervous system. All previously identified receptors were reidentified from the brain and/or eyestalk ganglia transcriptomes, i.e., dopamine alpha-1, beta-1, and alpha-2 (Homam-DAα2R) receptors, octopamine alpha (Homam-OctαR), beta-1, beta-2, beta-3, beta-4, and octopamine–tyramine (Homam-OTR-I) receptors, serotonin type-1A, type-1B (Homam-5HTR1B), type-2B, and type-7 receptors; and histamine type-1 (Homam-HA1R), type-2, type-3, and type-4 receptors. For many previously partial proteins, full-length receptors were deduced from brain and/or eyestalk ganglia transcripts, i.e., Homam-DAα2R, Homam-OctαR, Homam-OTR-I, and Homam-5HTR1B. In addition, novel dopamine/ecdysteroid, octopamine alpha-2, and OTR receptors were discovered, the latter, Homam-OTR-II, being a putative paralog of Homam-OTR-I. Finally, evidence for splice/other variants was found for many receptors, including evidence for some being assembly-specific, e.g., a brain-specific Homam-OTR-I variant and an eyestalk ganglia-specific Homam-HA1R variant. To increase confidence in the transcriptome-derived sequences, a subset of receptors was cloned using RT-PCR. These data complement/augment those reported previously, providing a more complete picture of amine receptor complement/diversity in the lobster nervous system.
Tradition et Nouveauté: Une étude du baccalauréat et de la réforme Blanquer
Date: 2020-01-01
Creator: Fiona Carey
Access: Open access
- The baccalauréat exam has played a significant role in the lives of French high schoolers for more than two centuries. Not only does the exam determine a student’s eligibility for university, it is a long-standing national tradition and an important aspect of French identity. The baccalauréat consists of a core curriculum and a choice of specialties, all of which prepare students for the exams that they will take in their last two years of high school. In 2018, Minister of Education Jean-Michel Blanquer announced a reform to the baccalauréat that would drastically alter the content and structure of the exam. Blanquer’s reform offers students a wider variety of specialties and in doing so hopes to eliminate the supposed hierarchies which have historically valued sciences over other subject matters. This reform revolutionizes the system while simultaneously remaining deeply rooted in tradition. While Blanquer’s reform introduces changes to the core curriculum and an entirely new list of specialties, it preserves other aspects of the French education system, particularly the mandatory study of philosophy. This thesis examines the contrasting novelty and tradition of Blanquer’s baccalauréat. In order to understand the intent and implications of his reform, this thesis studies a series of historic reforms, provides a detailed explanation of Blanquer’s changes, and finally discusses a selection of anonymous survey responses concerning its potential impacts. In discussing these survey responses, I highlight three main themes: (1) hierarchies and freedom of choice, (2) collectivity and individuality, and (3) the role of nationalism in the baccalauréat.
They Used to Be Castles Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2021-01-01
Creator: Lily Anna Fullam
Access: Access restricted to the Bowdoin Community
From “This Revolution is Neither Communist nor Capitalist!” to “Long Live the Socialist Revolution:” The Deterioration of U.S.-Cuban Relations from 1958-1961
Date: 2023-01-01
Creator: Julia Lyne
Access: Open access
- This thesis studies the deterioration of U.S.-Cuban relations from 1958-1961. Mainly drawing from primary sources from the National Archives, it seeks to answer and understand how and why relations deteriorated so rapidly. It pushes against the common belief that U.S.-Cuban relations were doomed from the start, instead highlighting in Chapter One Fidel Castro’s rise to power (and Fulgencio Batista’s fall from power) and revealing that the U.S. government was not entirely against Castro’s seizure of power. Chapter Two explores Castro’s first year in power and the (futile) attempts made by both governments to keep relations alive. Finally, it closes with the destruction of official and unofficial relations, suggesting that President Eisenhower’s covert approval of the invasion of the Bay of Pigs marked the covert ending to political relations as well as rising economic and political tensions due to an incompatibility of demand and interest in the sugar and oil industries. Ultimately, this thesis suggests that it was not just a matter of communism that led to the destruction of U.S.-Cuban relations at the time; instead, it was because of compounding effects of other various other economic and political factors and incompatibilities, such as the sugar and oil industries, public and political slandering and attacks from both sides, and an increasing acceptance of the Soviet Union and its supporters. This analysis does not seek to argue against the influence of communism in its entirety; rather, it aims to highlight and nuance the contributing factors to this deterioration.
Properties of Slicing Conditions for Charged Black Holes
Date: 2023-01-01
Creator: Sean E. Li
Access: Open access
- We consider an earlier analysis by Baumgarte and de Oliveira (2022) of static Bona-Massó slices of stationary, nonrotating, uncharged black holes, represented by Schwarzschild spacetimes, and generalize that approach to Reissner-Nordström (RN) spacetimes, representing stationary, nonrotating black holes that carry a nonzero charge. This charge is parametrized by the charge-to-mass ratio λ ≡ Q/M, where M is the black-hole mass and the charge Q may represent electrical charge or act as a placeholder for extensions of general relativity. We use a height-function approach to construct time-independent, spherically symmetric slices that satisfy a so-called Bona-Massó slicing condition. We compute quantities such as critical points and profiles of geometric quantities for several different versions of the Bona-Massó slicing condition. In some cases we do this analytically, while in others we use numerical root-finding to solve quartic equations. We conclude that in the extremal limit as λ → 1, all slices that we consider approach a unique slice that is independent of the chosen Bona-Massó condition. We then study dynamical, i.e. time-dependent, Bona-Massó slices by analytically predicting the qualitative behavior of the central lapse, i.e. the lapse at the black-hole puncture, for a particular slice that Alcubierre (1997) proposed to mitigate gauge shocks. These shock-avoiding slices are a viable alternative to the very common so-called 1 + log slices but exhibit different behavior in dynamical simulations. We use a perturbation of the radial coordinate at the location of the puncture to recover approximately harmonic late-time oscillations of the central lapse that Baumgarte and Hilditch (2022) observed in numerical simulations.
Structural and methodological factors influencing the sorption of alkylpyridiniums to aluminosilicates Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2023-01-01
Creator: Seamus Frey
Access: Access restricted to the Bowdoin Community
The Influence of Polymers on the Solubility of Flufenamic Acid and Mefenamic Acid Cocrystals This record is embargoed.
- Embargo End Date: 2027-05-16
Date: 2024-01-01
Creator: Morgan Adams
Access: Embargoed
The French Official Mistress: Fashioning Female Political Power in the Ancien Régime
Date: 2024-01-01
Creator: Samantha Brown
Access: Open access
- This thesis focuses on the French official mistress as a position of unofficial female political power under the French monarchy from the 16th to the 18th century. Centering on three case studies – Diane de Poitiers, Madame de Maintenon, and Madame de Pompadour – this thesis argues that the role of the official mistress extended beyond sexual companion to advisor, negotiator, diplomat, artistic patron, and cultural trendsetter. By taking a deep look at the epistolary and artistic record of these three official mistresses from across France’s modern history, the extent of their autonomy and political maneuvering becomes clear in the tactics they used to project and solidify their power. Diane de Poitiers, Madame de Maintenon, and Madame de Pompadour all existed in unique contexts of the French court and constructed their own methods of fulfilling the role of the official mistress, revealing both changes in the monarchy and their impacts upon it. Notably, the ways in which they projected identity through self-fashioning resulted in a reflection of this image back onto the monarch, expanding the extent of their impact on the monarchy. In striving to understand the political reality of women in France under Salic law and today, the position of maîtresse-en-titre is a crucial framework to recognize the significance of female power structures at court and in the monarchy, and the degree to which women were able to shape these structures themselves.
Examining the Effect of Aromatic Substituents in Peptoid Catalysts of Stereoselective Trifluoromethylation Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2024-01-01
Creator: Daniel Chi
Access: Access restricted to the Bowdoin Community