Showing 1541 - 1550 of 5709 Items
Assigning Legal Punishment: Individual Differences in Justice Sensitivity and Selective Attention
Date: 2015-05-01
Creator: Emily C. Weinberger
Access: Open access
- Selective attention and justice sensitivity (JS), a personality trait reflecting individual differences in perceptions of injustice, have been shown to affect how people assign punishments. In the present study peoples’ decision-making processes were investigated to better understand the inconsistencies in legal punishment decisions, particularly when using retributive versus restorative justice. Subjects participated in three phases of the experiment. First, subjects completed a justice sensitivity scale and then rated the appropriateness of punishment options to handle a criminal scenario. Second, participants’ selective attention was indicated by their recall of pertinent features from three ambiguous criminal scenarios. Finally, participants were primed with either restorative justice or neutral control words, and rated the appropriateness of punishment options to handle a new criminal scenario. Results revealed no significant associations between JS and ratings of punishment options, although patterns suggested negative relationships between observer JS and retributive justice ratings, and victim JS and restorative justice ratings. Results did show a significant effect of JS in predicting the facts remembered, such that as observer JS increased, more restorative justice facts were recalled, and as victim JS increased, fewer restorative justice facts were recalled. No significant effect of the restorative justice prime was observed. These results may contribute to better understanding of criminal justice policy in the United States.
The Structure and Unitary Representations of SU(2,1)
Date: 2015-05-01
Creator: Andrew J Pryhuber
Access: Open access
Haplotype mapping of a diploid non-meiotic organism using existing and induced aneuploidies
Date: 2008-01-01
Creator: Melanie Legrand, Anja Forche, Anna Selmecki, Christine Chan, David T., Kirkpatrick, Judith Berman
Access: Open access
- Haplotype maps (HapMaps) reveal underlying sequence variation and facilitate the study of recombination and genetic diversity. In general, HapMaps are produced by analysis of Single-Nucleotide Polymorphism (SNP) segregation in large numbers of meiotic progeny. Candida albicans, the most common human fungal pathogen, is an obligate diploid that does not appear to undergo meiosis. Thus, standard methods for haplotype mapping cannot be used. We exploited naturally occurring aneuploid strains to determine the haplotypes of the eight chromosome pairs in the C. albicans laboratory strain SC5314 and in a clinical isolate. Comparison of the maps revealed that the clinical strain had undergone a significant amount of genome rearrangement, consisting primarily of crossover or gene conversion recombination events. SNP map haplotyping revealed that insertion and activation of the UAU1 cassette in essential and non-essential genes can result in whole chromosome aneuploidy. UAU1 is often used to construct homozygous deletions of targeted genes in C. albicans; the exact mechanism (trisomy followed by chromosome loss versus gene conversion) has not been determined. UAU1 insertion into the essential ORC1 gene resulted in a large proportion of trisomic strains, while gene conversion events predominated when UAU1 was inserted into the non-essential LRO1 gene. Therefore, induced aneuploidies can be used to generate HapMaps, which are essential for analyzing genome alterations and mitotic recombination events in this clonal organism. © 2008 Legrand et al.
Investigating the Role of Interpretation Bias in Mindfulness-Based Treatment of Adults With Generalized Anxiety Disorder
Date: 2020-02-11
Creator: Elizabeth A. Hoge, Hannah E. Reese, Isabelle A. Oliva, Caroline D. Gabriel, Brittany M., Guidos, Eric Bui, Naomi M. Simon, Mary Ann Dutton
Access: Open access
- Although mindfulness-based interventions (MBIs) have garnered empirical support for a wide range of psychological conditions, the psychological processes that mediate the relationship between MBIs and subsequent symptomatic improvement are less well-understood. In the present study we sought to examine, for the first time, the relationship between mindfulness, negative interpretation bias as measured by the homophone task, and anxiety among adults with Generalized Anxiety Disorder (GAD). Forty-two individuals with GAD completed measures of mindfulness, interpretation bias, and anxiety before and after treatment with Mindfulness-based Stress Reduction (MBSR). Contrary to prior research, we did not find evidence of an indirect relationship between baseline levels of mindfulness and anxiety via negative interpretation bias. MBSR did result in significant reductions in negative interpretation bias from baseline to post-treatment; however, we did not find evidence of an indirect relationship between changes in mindfulness and changes in anxiety via changes in interpretation bias. Taken together, these results provide minimal support for the hypothesized relationship between mindfulness, negative interpretation bias, and anxiety among adults with GAD. Limitations and specific suggestions for further inquiry are discussed.
Interest groups in electoral politics: 2012 in context
Date: 2012-12-01
Creator: Michael M. Franz
Access: Open access
- This paper compares the levels of ad spending from outside groups and traditional party organizations across seven federal election cycles. The data show clearly that outside groups advertised at historic levels in 2012. Such intense efforts send two important signals to students of American campaign finance. The first involves a crisis in the system of limited donations to candidates and party committees moving forward. The second resurrects an old debate in political science about whether parties or candidates should be the center of our electoral process. The paper concludes with a consideration of possible reforms that might help restore parties and candidates to the center of issue debates in competitive federal elections.
Collecting Privately
Date: 1965-01-01
Access: Open access
- Exhibition catalogue from Bowdoin College Museum of Art.
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
Date: 2008-05-01
Creator: Anna Selmecki, Maryam Gerami-Nejad, Carsten Paulson, Anja Forche, Judith, Berman
Access: Open access
- Acquired azole resistance is a serious clinical problem that is often associated with the appearance of aneuploidy and, in particular, with the formation of an isochromosome [i(5L)] in the fungal opportunist Candida albicans. Here we exploited a series of isolates from an individual patient during the rapid acquisition of fluconazole resistance (FluR). Comparative genome hybridization arrays revealed that the presence of two extra copies of Chr5L, on the isochromosome, conferred increased FluR and that partial truncation of Chr5L reduced FluR. In vitro analysis of the strains by telomere-mediated truncations and by gene deletion assessed the contribution of all Chr5L genes and of four specific genes. Importantly, ERG11 (encoding the drug target) and a hyperactive allele of TAC1 (encoding a transcriptional regulator of drug efflux pumps) made independent, additive contributions to FluR in a gene copy number-dependent manner that was not different from the contributions of the entire Chr5L arm. Thus, the major mechanism by which i(5L) formation causes increased azole resistance is by amplifying two genes: ERG11 and TAC1. © 2008 The Authors.
Are melanized feather barbs stronger?
Date: 2004-01-01
Creator: Michael Butler, Amy S. Johnson
Access: Open access
- Melanin has been associated with increased resistance to abrasion, decreased wear and lowered barb breakage in feathers. But, this association was inferred without considering barb position along the rachis as a potentially confounding variable. We examined the cross-sectional area, breaking force, breaking stress, breaking strain and toughness of melanized and unmelanized barbs along the entire rachis of a primary feather from an osprey (Pandion haliaetus). Although breaking force was higher for melanized barbs, breaking stress (force divided by cross-sectional area) was greater for unmelanized barbs. But when position was considered, all mechanical differences between melanized and unmelanized barbs disappeared. Barb breaking stress, breaking strain and toughness decreased, and breaking stiffness increased, distally along the rachis. These proximal-distal material property changes are small and seem unlikely to affect flight performance of barbs. Our observations of barb bending, breaking and morphology, however, lead us to propose a design principle for barbs. We propose that, by being thicker-walled dorso-ventrally, the barb's flexural stiffness is increased during flight; but, by allowing for twisting when loaded with dangerously high forces, barbs firstly avoid failure by bending and secondly avoid complete failure by buckling rather than rupturing.