Showing 181 - 190 of 733 Items
Bio-optical discrimination of diatoms from other phytoplankton in the surface ocean: Evaluation and refinement of a model for the Northwest Atlantic
Date: 2018-11-01
Creator: Sasha J. Kramer, Collin S. Roesler, Heidi M. Sosik
Access: Open access
- Diatoms dominate global silica production and export production in the ocean; they form the base of productive food webs and fisheries. Thus, a remote sensing algorithm to identify diatoms has great potential to describe ecological and biogeochemical trends and fluctuations in the surface ocean. Despite the importance of detecting diatoms from remote sensing and the demand for reliable methods of diatom identification, there has not been a systematic evaluation of algorithms that are being applied to this end. The efficacy of these models remains difficult to constrain in part due to limited datasets for validation. In this study, we test a bio-optical algorithm developed by Sathyendranath et al. (2004) to identify diatom dominance from the relationship between ratios of remote sensing reflectance and chlorophyll concentration. We evaluate and refine the original model with data collected at the Martha's Vineyard Coastal Observatory (MVCO), a near-shore location on the New England shelf. We then validated the refined model with data collected in Harpswell Sound, Maine, a site with greater optical complexity than MVCO. At both sites, despite relatively large changes in diatom fraction (0.8–82% of chlorophyll concentration), the magnitude of variability in optical properties due to the dominance or non-dominance of diatoms is less than the variability induced by other absorbing and scattering constituents of the water. While the original model performance was improved through successive re-parameterizations and re-formulations of the absorption and backscattering coefficients, we show that even a model originally parameterized for the Northwest Atlantic and re-parameterized for sites such as MVCO and Harpswell Sound performs poorly in discriminating diatom-dominance from optical properties.
The_Wisconsin_Card_Sorting_Test_and_the_cognitive_assessment
Date: 2009-12-01
Creator: Erika Nyhus, Francisco Barceló
Access: Open access
Learning cognitive maps: Finding useful structure in an uncertain world
Date: 2008-05-22
Creator: Eric Chown, Byron Boots
Access: Open access
- In this chapter we will describe the central mechanisms that influence how people learn about large-scale space. We will focus particularly on how these mechanisms enable people to effectively cope with both the uncertainty inherent in a constantly changing world and also with the high information content of natural environments. The major lessons are that humans get by with a "less is more" approach to building structure, and that they are able to quickly adapt to environmental changes thanks to a range of general purpose mechanisms. By looking at abstract principles, instead of concrete implementation details, it is shown that the study of human learning can provide valuable lessons for robotics. Finally, these issues are discussed in the context of an implementation on a mobile robot. © 2007 Springer-Verlag Berlin Heidelberg.
Design of a drug discovery course for non-science majors
Date: 2018-07-01
Creator: Danielle H. Dube
Access: Open access
- “Drug Discovery” is a 13-week lecture and laboratory-based course that was developed to introduce non-science majors to foundational chemistry and biochemistry concepts as they relate to the unifying theme of drug discovery. The first part of this course strives to build students' understanding of molecules, their properties, the differences that enable them to be separated from one another, and their abilities to bind to biological receptors and elicit physiological effects. After building students' molecular worldview, the course then focuses on four classes of drugs: antimicrobials, drugs that affect the mind, steroid-based drugs, and anti-cancer drugs. During each of these modules, an emphasis is placed on how understanding the basis of disease and molecular-level interactions empowers us to identify novel medicinal compounds. Periodic in class discussions based on articles pertinent to class topics ranging from the spread of antibiotic resistance, to the molecular basis of addiction, to rational drug design, are held to enable students to relate course material to pressing problems of national and daily concern. In addition to class time, weekly inquiry-based laboratories allow students to critically analyze data related to course concepts, and later in the semester give students an opportunity to design and implement their own experiments to screen for antimicrobial activity. This course provides students with an understanding of the importance of chemistry and biochemistry to human health while emphasizing the process, strategies, and challenges related to drug discovery. © 2018 by The International Union of Biochemistry and Molecular Biology, 46:327–335, 2018.
Partner choice in spontaneous mitotic recombination in wild type and homologous recombination mutants of Candida albicans
Date: 2019-11-01
Creator: Alberto Bellido, Toni Ciudad, Belén Hermosa, Encarnación Andaluz, Anja, Forche, Germán Larriba
Access: Open access
- Candida albicans, the most common fungal pathogen, is a diploid with a genome that is rich in repeats and has high levels of heterozygosity. To study the role of different recombination pathways on direct-repeat recombination, we replaced either allele of the RAD52 gene (Chr6) with the URA-blaster cassette (hisG-URA3-hisG), measured rates of URA3 loss as resistance to 5-fluoroorotic acid (5FOAR) and used CHEF Southern hybridization and SNP-RFLP analysis to identify recombination mechanisms and their frequency in wildtype and recombination mutants. FOAR rates varied little across different strain backgrounds. In contrast, the type and frequency of mechanisms underlying direct repeat recombination varied greatly. For example, wildtype, rad59 and lig4 strains all displayed a bias for URA3 loss via pop-out/deletion vs. inter-homolog recombination and this bias was reduced in rad51 mutants. In addition, in rad51-derived 5FOAR strains direct repeat recombination was associated with ectopic translocation (5%), chromosome loss/truncation (14%) and inter-homolog recombination (6%). In the absence of RAD52, URA3 loss was mostly due to chromosome loss and truncation (80–90%), and the bias of retained allele frequency points to the presence of a recessive lethal allele on Chr6B. However, a few single-strand annealing (SSA)-like events were identified and these were independent of either Rad59 or Lig4. Finally, the specific sizes of Chr6 truncations suggest that the inserted URA-blaster could represent a fragile site.
Kyanite preserves prograde and retrograde metamorphic events as revealed by cathodoluminescence, geochemistry, and crystallographic orientation
Date: 2021-01-01
Creator: Emily M. Peterman, Michael J. Jercinovic, Rachel J. Beane, Cameron B. de Wet
Access: Open access
- Cathodoluminescence (CL) images of kyanite reveal several internal textures, including sector zoning, oscillatory zoning, and cross-cutting relationships among different domains. Many textures observed in kyanite correspond to discrete events, thereby connecting kyanite textures to the pressure–temperature (P–T) history of the rock. To evaluate the record of metamorphism preserved by kyanite, metapelites were selected from three different orogens that reflect P–T conditions ranging from amphibolite to ultrahigh-pressure (UHP) facies. Cross-correlation of variations in CL intensity, chemistry, and crystal orientation within kyanite indicate the following findings. First, the preservation of original growth zones in kyanite from poly-metamorphic rocks demonstrates that growth zoning in kyanite persists through metamorphic events and is not erased by diffusion or complete recrystallization. In some samples, kyanite retains evidence of its reaction history during growth. Second, measured changes in absolute crystallographic orientation do not correspond with changes in CL intensity in any of the measured samples, including kyanite twins. Third, both kink banding and undulatory extinction are present across all samples, consistent with rotation about in the (100)[001] slip system. Kyanite from (U)HP samples exhibits higher amplitude undulations than kyanite from lower-grade lithologies, suggesting that crystallographic orientation data may provide complementary insight about deformation along the P–T path. Fourth, specific CL and trace element signatures in kyanite can be correlated with discrete metamorphic histories; yet, CL intensity and colour are affected by multiple elements, not a single controlling element. In sum, multiple generations of kyanite can be identified by careful cross-correlation of CL and geochemical data, and when combined with crystal orientation data, kyanite provides a robust record of a rock's P–T evolution.
Nonlinear coherent structures in granular crystals
Date: 2017-09-06
Creator: C. Chong, Mason A. Porter, P. G. Kevrekidis, C. Daraio
Access: Open access
- The study of granular crystals, which are nonlinear metamaterials that consist of closely packed arrays of particles that interact elastically, is a vibrant area of research that combines ideas from disciplines such as materials science, nonlinear dynamics, and condensed-matter physics. Granular crystals exploit geometrical nonlinearities in their constitutive microstructure to produce properties (such as tunability and energy localization) that are not conventional to engineering materials and linear devices. In this topical review, we focus on recent experimental, computational, and theoretical results on nonlinear coherent structures in granular crystals. Such structures - which include traveling solitary waves, dispersive shock waves, and discrete breathers - have fascinating dynamics, including a diversity of both transient features and robust, long-lived patterns that emerge from broad classes of initial data. In our review, we primarily discuss phenomena in one-dimensional crystals, as most research to date has focused on such scenarios, but we also present some extensions to two-dimensional settings. Throughout the review, we highlight open problems and discuss a variety of potential engineering applications that arise from the rich dynamic response of granular crystals.
Production and decay of D1 (2420)0 and D2* (2460)0
Date: 1994-06-30
Creator: P. Avery, A. Freyberger, J. Rodriguez, R. Stephens, S., Yang, J. Yelton, D. Cinabro, S. Henderson, T. Liu, M. Saulnier, R. Wilson, H. Yamamoto, T. Bergfeld, B. I. Eisenstein, G. Gollin, B. Ong, M. Palmer, M. Selen, J. J. Thaler, K. W. Edwards, M. Ogg, B. Spaan, A. Bellerive, D. I. Britton, E. R.F. Hyatt, D. B. MacFarlane, P. M. Patel, A. J. Sadoff, R. Ammar, S. Ball, P. Baringer
Access: Open access
- We have investigated D+ π- and D*+ π- final states and observed the two established L = 1 charmed mesons, the D1 (2420)0 with mass 2421-2-2+1+2 MeV/c2 and width 20-5-3+6+3 MeV/c2 and the D2* (2460)0 with mass 2465 ± 3 ± 3 MeV/c2 and width 28-7-6+8+6 MeV/c2. Properties of these final states, including their decay angular distributions and spin-parity assignments, have been studied. We identify these two mesons as the jlight = 3 2 doublet predicted by HQET. We also obtain constraints on Γs/ (Γs + ΓD) as a function of the cosine of the relative phase of the two amplitudes in the D1 (2420)0 decay. © 1994.
Two-photon production of charged pion and kaon pairs
Date: 1994-01-01
Creator: J. Dominick, M. Lambrecht, S. Sanghera, V. Shelkov, T., Skwarnicki, R. Stroynowski, I. Volobouev, G. Wei, P. Zadorozhny, M. Artuso, M. Goldberg, D. He, N. Horwitz, R. Kennett, R. Mountain, G. C. Moneti, F. Muheim, Y. Mukhin, S. Playfer, Y. Rozen, S. Stone, M. Thulasidas, G. Vasseur, G. Zhu, J. Bartelt, S. E. Csorna, Z. Egyed, V. Jain, K. Kinoshita, K. W. Edwards, M. Ogg
Access: Open access
- A measurement of the cross section for the combined two-photon production of charged pion and kaon pairs is performed using 1.2 fb-1 of data collected by the CLEO II detector at the Cornell Electron Storage Ring. The cross section is measured at invariant masses of the two-photon system between 1.5 and 5.0 GeV/c2, and at scattering angles more than 53° away from the γγ collision axis in the γγ center-of-mass frame. The large background of leptonic events is suppressed by utilizing the CsI calorimeter in conjunction with the muon chamber system. The reported cross section is compared with leading order QCD models as well as previous experiments. Although the functional dependence of the measured cross section disagrees with leading order QCD at small values of the two-photon invaraint mass, the data show qualitatively a transition to perturbative behavior at an invariant mass of approximately 2.5 GeV/c2. © 1994 The American Physical Society.
Measurement of the branching fraction scrB(τ-→h- →π0ντ)
Date: 1994-01-01
Creator: M. Artuso, M. Goldberg, D. He, N. Horwitz, R., Kennett, R. Mountain, G. C. Moneti, F. Muheim, Y. Mukhin, S. Playfer, Y. Rozen, S. Stone, M. Thulasidas, G. Vasseur, X. Xing, G. Zhu, J. Bartelt, S. E. Csorna, Z. Egyed, V. Jain, K. Kinoshita, B. Barish, M. Chadha, S. Chan, D. F. Cowen, G. Eigen, J. S. Miller, C. O'Grady, J. Urheim, A. J. Weinstein, D. Acosta
Access: Open access
- Using data from the CLEO II detector at the Cornell Electron Storage Ring, we measure scrB(τ-→h-π0ντ) where h- refers to either π- or K-. We use three different methods to measure this branching fraction. The combined result is scrB(τ-→h-π0ντ)=0.2587±0. 0012±0.0042, in good agreement with standard model predictions. © 1994 The American Physical Society.