Showing 951 - 1000 of 7462 Items

Date: 2020-01-01

Creator: Susan Graham

Access: Open access

Susan Graham, a Bowdoin College housekeeper for 14 years, shares her experiences cleaning for the Environmental Services team of Mid Coast Hospital in Brunswick, Maine during the Covid19 crisis. Susan was hired by the hospital after she offered assistance during her hiatus from Bowdoin, when the campus was closed to all but essential personnel in the weeks following March 18th, 2020. Susan also reflects on the impact of the crisis on her home life and her work at Bowdoin. Interviewed by Bowdoin Archivist, Caroline Moseley.

Date: 1978-01-01

Access: Open access

Date: 1988-01-01

Creator: Patricia McGraw

Access: Open access

Typesetting: The Anthoensen Press. Includes bibliographical references (p. [206]-[214]) and index.

Date: 2021-07-15

Creator: Phuong Luong, Danielle H. Dube

Access: Open access

The bacterial glycocalyx is a quintessential drug target comprised of structurally distinct glycans. Bacterial glycans bear unusual monosaccharide building blocks whose proper construction is critical for bacterial fitness, survival, and colonization in the human host. Despite their appeal as therapeutic targets, bacterial glycans are difficult to study due to the presence of rare bacterial monosaccharides that are linked and modified in atypical manners. Their structural complexity ultimately hampers their analytical characterization. This review highlights recent advances in bacterial chemical glycobiology and focuses on the development of chemical tools to probe, perturb, and image bacterial glycans and their biosynthesis. Current technologies have enabled the study of bacterial glycosylation machinery even in the absence of detailed structural information.

Date: 1975-01-01

Creator: Zdenka Volavka

Access: Open access

"Composition by the Anthoensen Press, Portland, Maine"--P. [2]

Date: 1977-01-01

Access: Open access

Catalog of the exhibition held Jan. 21-Feb. 27, 1977.

Date: 1870-01-01

Access: Open access

"Note" signed: J.B.S

Date: 1962-01-01

Access: Open access

Handlist of an exhibition held at the Walker Art Museum, Bowdoin College, Brunswick, Maine, May 11-June 17, 1962.

Date: 2017-05-01

Creator: Chaiyaboot Ariyachet, Christian Beißel, Xiang Li, Selena Lorrey, Olivia, Mackenzie, Patrick M. Martin, Katharine O'Brien, Tossapol Pholcharee, Sue Sim, Heike Krebber, Anne E. McBride

Access: Open access

The morphological transition of the opportunistic fungal pathogen Candida albicans from budding to hyphal growth has been implicated in its ability to cause disease in animal models. Absence of SR-like RNA-binding protein Slr1 slows hyphal formation and decreases virulence in a systemic candidiasis model, suggesting a role for post-transcriptional regulation in these processes. SR (serine–arginine)-rich proteins influence multiple steps in mRNA metabolism and their localization and function are frequently controlled by modification. We now demonstrate that Slr1 binds to polyadenylated RNA and that its intracellular localization is modulated by phosphorylation and methylation. Wildtype Slr1-GFP is predominantly nuclear, but also co-fractionates with translating ribosomes. The non-phosphorylatable slr1-6SA-GFP protein, in which six serines in SR/RS clusters are substituted with alanines, primarily localizes to the cytoplasm in budding cells. Intriguingly, hyphal cells display a slr1-6SA-GFP focus at the tip near the Spitzenkörper, a vesicular structure involved in molecular trafficking to the tip. The presence of slr1-6SA-GFP hyphal tip foci is reduced in the absence of the mRNA-transport protein She3, suggesting that unphosphorylated Slr1 associates with mRNA–protein complexes transported to the tip. The impact of SLR1 deletion on hyphal formation and function thus may be partially due to a role in hyphal mRNA transport.

Date: 1977-01-01

Creator: Benjamin Forgery

Access: Open access

Catalogue of an exhibition organized by the Bowdoin College Museum of Art; participating museums: Bowdoin College Museum of Art, Aug. 5-Sept. 25, 1977; Virginia Museum of Fine Arts, Oct. 18-Nov. 20, 1977; Seattle Art Museum, May 18-June 25, 1978; Textile Museum, Sept. 15-Oct. 28, 1978.

Date: 2017-05-26

Creator: Nicole Sadowsky, Erik Nelson

Access: Open access

Since 2011, the private ride-hailing companies Uber and Lyft have expanded into more and more US cities. We use regression discontinuity design to examine the impact of Uber and Lyft’s entry on public transportation use in the US’ largest urban areas. In most cases, entry into cities by the two ride-hailing companies was staggered: Uber entered first followed some months later by Lyft. We find that public transportation use increased in an urban area, all else equal, immediately following the first entry. However, we find that the spike in public transportation use after first entry disappeared following the entry of the second company. In fact there is some evidence that monthly public transportation ridership levels fell below their pre-first entry levels. In other words, the joint presence of the two major private ride-hailing services transformed ride-hailing services from a public transportation complement to a public transportation substitute, at least in the studied urban areas. We speculate that the first entrant complemented public transportation use for some in an urban area by solving the “last-mile” problem and by providing a potentially safer option at night when public transportation service has been reduced. However, we speculate the second entrant is likely to have spurred price competition in the urban area’s ride-hailing duopoly market and an increase in ride-hailing car supply. This competitive effect could have tipped the scales, making an entire trip with a ride-hailing service more cost-effective and convenient than splitting a trip between a ride-share company and public transportation.

Date: 2020-12-01

Creator: Charles Dorn

Access: Open access

In 1975, the United Nations, under the auspices of its Educational, Scientific and Cultural Organization (UNESCO) and Environment Program (UNEP), established the International Environmental Education Program (IEEP). For two decades, IEEP aimed to accomplish goals ascribed to it by UNESCO member states and fostered communication across the international community through Connect, the UNESCO-UNEP environmental education newsletter. After reviewing UNESCO’s early involvement with the environment, this study examines IEEP’s development, beginning with its conceptual grounding in the 1968 UNESCO Biosphere Conference. It examines the 1972 United Nations Conference on the Human Environment held in Stockholm, moves on to the UNESCO-UNEP 1975 Belgrade Workshop, and continues with the world’s first intergovernmental conference dedicated to environmental education held in Tbilisi in 1977. The paper then uses Connect to trace changes in the form and content of environmental education. Across two decades, environmental education shifted from providing instruction about nature protection and natural resource conservation to fostering an environmental ethic through a problems-based, interdisciplinary study of the ecology of the total environment to adopting the concept of sustainable development. IEEP ultimately met with mixed success. Yet it was the primary United Nations program assigned the task of creating and implementing environmental education globally and thus offers a particularly useful lens through which to analyze changes in the international community’s understanding of the concept of the environment over time.

Date: 2001-07-13

Creator: Anne E. McBride, Pamela A. Silver

Access: Open access

Date: 1875-01-01

Access: Open access

Date: 2019-02-01

Creator: Erik Nelson, John Fitzgerald, Nathan Tefft

Access: Open access

Consumer spending on organic food products has grown rapidly. Some claim that organics have ecological, equity, and health advantages over conventional food and therefore should be subsidized. Here we explore the distributive impacts of an organic fruit subsidy that reduces the retail price of organic fruit in the US by 10 percent. We estimate the impact of the subsidy on organic fruit demand in a representative poor, middle income, and rich US household using three analytical methods; including two econometric and one machine learning. We do not find strong evidence of regressive redistribution due to our simulated organic fruit subsidy; the poor household’s relative reaction to the subsidy is not much different than the reaction at the other two households. However, the infra-marginal savings from the subsidy tend to be larger in richer households.

Date: 2013-08-01

Creator: Stephen Polasky, David Lewis, Andrew Plantinga, Erik Nelson

Access: Open access

Many ecosystem services are public goods whose provision depends on the spatial pattern of land use. The pattern of land use is often determined by the decisions of multiple private landowners. Increasing the provision of ecosystem services, while beneficial for society as a whole, may be costly to private landowners. A regulator interested in providing incentives to landowners for increased provision of ecosystem services often lacks complete information on landowners’ costs. The combination of spatially-dependent benefits and asymmetric cost information means that the optimal provision of ecosystem services cannot be achieved using standard regulatory or payment for ecosystem services (PES) approaches. Here we show that an auction that pays a landowner for the increased value of ecosystem services generated by the landowner’s actions provides incentives for landowners to truthfully reveal cost information, and allows the regulator to implement the optimal provision of ecosystem services, even in the case with spatially-dependent benefits and asymmetric information.

Date: 2016-09-01

Creator: Erik Nelson, Clare Bates Congdon

Access: Open access

We identify the agricultural inputs that drove the growth in global and regional crop yields from 1975 to the mid-2000s. We find that improvements in agricultural technology, increased fertilizer use, and changes in crop mix around the world explained most of the gain in global crop yields, although impacts varied across the latitude gradient. Climate change over this time period caused yields to be only slightly lower than they would have been otherwise. In some cases cropland extensification had as much of a negative impact on global and regional yields as climate change. To maintain the momentum in yield growth across the globe 1) use of agricultural chemicals and investment in agricultural technology in the tropics must increase rapidly and 2) international trade in agricultural products must expand significantly.

Date: 1874-01-01

Access: Open access

Date: 2020-01-01

Creator: Crystal Hall

Access: Open access

Date: 2016-09-13

Creator: Crystal Hall

Access: Open access

This data set represents a first attempt to identify the North American colleges and universities that offer Italian courses at any level and also have support for digital humanities (DH) pedagogy or scholarship at any level. The list of schools with Italian programs was developed using the American Association of Teachers of Italian (AATI) list of undergraduate and graduate programs and College Source as of July 2016. The list was supplemented by checking if institutions listed with CenterNet (for Digital Humanities Centers) also have Italian programs. Overall, 10% of the Italian programs identified were not included in the AATI list, from the level of service courses through Masters degree. A search of each institution’s website was then performed to determine the level of DH resources available. Based on this collected data, 70% of North American colleges and universities that offer Italian also offer support for digital humanities courses or research through a center/lab, courses, major or minor programs, certificates, or graduate programs. A supplemental code sheet is available. Further analysis is provided in the author’s working paper “Digital Humanities & Italian Studies: Intersections and Oppositions” that is part of the State of the Discipline symposium organized by Wellesley College, October 1, 2016. (The data has been updated since the circulation of that paper, so numbers may not match.) The topic will be addressed in more detail based on the related survey and presentation at MLA 2017.

Date: 2000-02-04

Creator: Anne E. McBride, Valerie H. Weiss, Heidi K. Kim, James M. Hogle, Pamela A., Silver

Access: Open access

Many eukaryotic RNA-binding proteins are modified by methylation of arginine residues. The yeast Saccharomyces cerevisiae contains one major arginine methyltransferase, Hmt1p/Rmt1p, which is not essential for normal cell growth. However, cells missing HMT1 and also bearing mutations in the mRNA-binding proteins Np13p or Cbp80p can no longer survive, providing genetic backgrounds in which to study Hmt1p function. We now demonstrate that the catalytically active form of Hmt1p is required for its activity in vivo. Amino acid changes in the putative Hmt1p S-adenosyl-L-methionine-binding site were generated and shown to be unable to catalyze methylation of Np13p in vitro and in vivo or to restore growth to strains that require HMT1. In addition these mutations affect nucleocytoplasmic transport of Np13p. A cold- sensitive mutant of Hmt1p was generated and showed reduced methylation of Np13p, but not of other substrates, at 14 °C. These results define new aspects of Hmt1 and reveal the importance of its activity in vivo.

Date: 2020-01-01

Creator: Nora Pierson

Access: Open access

How having Multiple Sclerosis has prepared me for life in the time of Covid-19. The author is an alumna from the class of 2000.

Date: 2016-06-01

Creator: Daniel F. Stone, Jeremy Arkes

Access: Open access

Pope and Schweitzer (2011) study predictions of prospect theory for the reference point of par on the current hole in professional golf. We study prospect-theory predictions of three other plausible reference points: par for recent holes, for the round, and for the tournament. A potentially competing force is momentum in quality of play, that is, the hot or cold hand. While prospect theory predicts negative serial correlation in better (worse)-than-average performance across holes, the hot (cold) hand implies the opposite. We find evidence that, for each of the reference points we study, when scores are better than par, hot-hand effects are dominated by prospect-theory effects. These effects can occur via two mechanisms: greater conservatism or less effort. We find evidence that the former (latter) dominates for scores closer to (further from) the reference point. We also find evidence of prospect theory effects (greater risk seeking) when scores are worse than par for the round in Round 1 and of cold-hand effects for scores worse than par for the tournament in Round 3. The magnitudes of some of the joint effects are comparable to those found by Pope and Schweitzer and other related papers. We conclude by discussing how, rather than compete, prospect-theory and cold-hand forces might also cause one another.

Date: 2014-08-01

Creator: Amanda Howard

Access: Open access

Neuropeptides are small signaling molecules found throughout the nervous system that are responsible for influencing animal behavior. They consist of short amino acid chains and interact with cell-membrane receptors in order to regulate behavioral responses (Fig. 1a). The American lobster, Homarus americanus, has proven to be a strong model organism in which to study such activity due to the simplicity of the system and the wealth of existing knowledge about the animal. One neuropeptide found in H. americanus is a C-type allatostatin (AST-C). Allatostatins are a family of neuropeptides originally identified in insects that inhibits juvenile hormone production. The H. americanus AST-C has a pyroglutamate blocked N-terminus and an unmodified C-terminus (Fig. 1b). In addition to AST-C, a different, yet structurally similar neuropeptide has been found in H. americanus. This peptide has an unmodified N-terminus and an amidated C-terminus (Fig. 1c). Both forms of AST-C (referred to as ASTC-real and ASTC-like) also have a disulfide bond between their two cysteine residues. In the lobster, both peptides influence cardiac muscle contraction patterns and have been found in various tissues throughout the nervous system [1, 2]. In order to establish the purpose of the observed post-translational modifications, this study aims to find whether these peptides exist in other forms in the lobster and to determine their relative and absolute concentrations.Liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS/MS) are often used in analytical chemistry to characterize complex samples and identify neuropeptides. First, sample components are separated by chromatography based on properties such as size and hydrophobicity. Using mass spectrometry (MS), peptides are protonated (positively charged) and their mass is determined from their measured mass-to-charge ratios. These peptides are lastly fragmented into many ions using MS/MS, which ultimately allows them to be sequenced in order to determine their identity. This summer, standards of the two AST-C peptides have been characterized by LC-MS/MS. The reduced forms of both peptides have been synthesized by chemically reducing the disulfide bond and were also analyzed by MS/MS. As expected, the structural stability provided by the disulfide bond prevented fragmentation during MS/MS analysis; that is, there was evidence of more fragmentation in the reduced forms than in the fully processed forms (Fig. 2). When looking for other forms of ASTC, these findings will facilitate the identification of the reduced forms in crustacean tissue.To assess the accuracy of the detection method used, detection limits were assessed by analyzing sample matrices augmented with known amounts of peptide standards. The smallest amount of peptide detected from a single injection was 25 fmol (2.5·10-14 mol) peptide. There appeared to be a strongly linear relationship between the amount of ASTC-real injected and the instrument response (chromatographic peak area) (R2=0.996, n=6). However, the relationship between the amount of ASTC-like injected and the instrument response was less linear (R2=0.802, n=5), and the calibration slope was more shallow, indicating that this peptide is more difficult to detect. This is possibly because ASTC-real, unlike ASTC-like, contains an arginine (R) and a histidine (H) residue, two basic amino acids susceptible to protonation. Therefore, it seems that ASTC-real is more easily protonated during the ionization process in MS analysis, causing it to be more readily detected.Lastly, ASTC-real has been identified in the pericardial organ (PO), a tissue responsible for delivering neuropeptides manufactured in the thoracic ganglion to the heart in order to control muscle contraction. ASTC-like is also believed to be present in the PO based on previous work in the Dickinson lab (E. Dickinson, unpublished data), but it is likely that it has not yet been detected in this study due to the detection limitations described above. To address these issues, more tissues will be pooled to increase the amount of peptide in each sample analyzed.Currently, tissue extraction methods are being optimized to eliminate phospholipid contamination and to maximize detection sensitivity. Specifically, two separate extraction solvents as well as a chloroform delipidation procedure are being tested. Future goals include quantifying peptide levels by adding a known amount of internal standard to the samples and comparing instrument responses for ASTC and for internal standard. Additionally, known amounts of peptide standard will be brought through the extraction process to determine the amount of peptide loss throughout this procedure. During the upcoming academic year, this study will be continued as an Honor’s project. Further research in these areas will ultimately help explain how neuropeptides interact to regulate behavior within the lobster and in more complex systems. Final Report of research funded by the Henry L. and Grace Doherty Charitable Foundation Coastal Studies Research Fellowship.

Date: 2019-05-01

Creator: Casey Breslow

Access: Open access

Modulation in neural systems is important for regulating physiology and behavior (Wright et al., 2010). Peptides, hormones, and amines are common neural modulators, acting on many neural systems across species. One group of neural networks that can be regulated are central pattern generators (CPGs), which generate rhythmic neural patterns, which drive behaviors (Marder and Bucher, 2001). Octopamine, and its precursor tyramine, are two amines that have been found to regulate (CPGs) across species (Cooke, 2002; Fussnecker et al., 2006). One role of octopamine in the decapod neurogenic heart is regulating the frequency and the duration of heart beats. However, the precise site of octopamine modulation within the cardiac system is not yet known (Kurumoto and Ebara, 1991). One possible site of action is the cardiac ganglion (CG), the CPG in decapod hearts. The transcripts for the enzymes required to synthesize octopamine from tyramine have been identified and localized in the CG (Christie et al., 2018). This would suggest that octopamine is produced in the CG, where it could have a direct action on those neurons, or it could be released peripherally. We have found individual variation in the response to octopamine and its precursor tyramine, and significant effects of frequency and contraction amplitude in the whole heart.

Date: 2014-01-01

Creator: Zicheng Yu, Julie Loisel, Daniel J. Charman, David W. Beilman, Philip, Camill

Access: Open access

Peatlands represent the largest and most concentrated carbon pool in the terrestrial biosphere, and their dynamics during the Holocene have had significant impacts on the global carbon cycle. In this Introduction paper, we provide an overview of the contributions presented in this Special Issue on Holocene peatland carbon dynamics. We also provide a brief history and current status of peat-core-based research on peatland carbon dynamics. Finally, we identify and discuss some challenges and opportunities that would guide peatland carbon research in the near future. These challenges and opportunities include the need to fill data gaps and increase geographic representations of peat carbon accumulation records, a better understanding of peatland lateral expansion process and improved estimate of peatland area change over time, developing regional carbon accumulation histories and carbon pool estimates, and projecting and quantifying overall peatland net carbon balance in a changing world.

Date: 2019-05-01

Creator: Duncan Gans

Access: Open access

Date: 2006-07-21

Creator: Anna Selmecki, Anja Forche, Judith Berman

Access: Open access

Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans. We found that aneuploidy in general and a specific segmental aneuploidy, consisting of an isochromosome composed of the two left arms of chromosome 5, were associated with azole resistance. The isochromosome forms around a single centromere flanked by an inverted repeat and was found as an independent chromosome or fused at the telomere to a full-length homolog of chromosome 5. Increases and decreases in drug resistance were strongly associated with gain and loss of this isochromosome, which bears genes expressing the enzyme in the ergosterol pathway targeted by azole drugs, efflux pumps, and a transcription factor that positively regulates a subset of efflux pump genes.

Date: 2012-01-01

Creator: Alexandre Heeren, Hannah E. Reese, Richard J. McNally, Pierre Philippot

Access: Open access

Social phobics exhibit an attentional bias for threat in probe detection and probe discrimination paradigms. Attention training programs, in which probes always replace nonthreatening cues, reduce attentional bias for threat and self-reported social anxiety. However, researchers have seldom included behavioral measures of anxiety reduction, and have never taken physiological measures of anxiety reduction. In the present study, we trained individuals with generalized social phobia (n = 57) to attend to threat cues (attend to threat), to attend to positive cues (attend to positive), or to alternately attend to both (control condition). We assessed not only self-reported social anxiety, but also behavioral and physiological measures of social anxiety. Participants trained to attend to nonthreatening cues demonstrated significantly greater reductions in self-reported, behavioral, and physiological measures of anxiety than did participants from the attend to threat and control conditions. © 2011 Elsevier Ltd.

Date: 1908-01-01

Access: Open access

Date: 2014-12-01

Creator: G. Hugelius, J. Strauss, S. Zubrzycki, J. W. Harden, E. A.G., Schuur, C. L. Ping, L. Schirrmeister, G. Grosse, G. J. Michaelson, C. D. Koven, J. A. O'Donnell, B. Elberling, U. Mishra, P. Camill, Z. Yu, J. Palmtag

Access: Open access

Soils and other unconsolidated deposits in the northern circumpolar permafrost region store large amounts of soil organic carbon (SOC). This SOC is potentially vulnerable to remobilization following soil warming and permafrost thaw, but SOC stock estimates were poorly constrained and quantitative error estimates were lacking. This study presents revised estimates of permafrost SOC stocks, including quantitative uncertainty estimates, in the 0-3 m depth range in soils as well as for sediments deeper than 3 m in deltaic deposits of major rivers and in the Yedoma region of Siberia and Alaska. Revised estimates are based on significantly larger databases compared to previous studies. Despite this there is evidence of significant remaining regional data gaps. Estimates remain particularly poorly constrained for soils in the High Arctic region and physiographic regions with thin sedimentary overburden (mountains, highlands and plateaus) as well as for deposits below 3 m depth in deltas and the Yedoma region. While some components of the revised SOC stocks are similar in magnitude to those previously reported for this region, there are substantial differences in other components, including the fraction of perennially frozen SOC. Upscaled based on regional soil maps, estimated permafrost region SOC stocks are 217 ± 12 and 472 ± 27 Pg for the 0-0.3 and 0-1 m soil depths, respectively (±95% confidence intervals). Storage of SOC in 0-3 m of soils is estimated to 1035 ± 150 Pg. Of this, 34 ± 16 Pg C is stored in poorly developed soils of the High Arctic. Based on generalized calculations, storage of SOC below 3 m of surface soils in deltaic alluvium of major Arctic rivers is estimated as 91 ± 52 Pg. In the Yedoma region, estimated SOC stocks below 3 m depth are 181 ± 54 Pg, of which 74 ± 20 Pg is stored in intact Yedoma (late Pleistocene ice- and organic-rich silty sediments) with the remainder in refrozen thermokarst deposits. Total estimated SOC storage for the permafrost region is ∼1300 Pg with an uncertainty range of ∼1100 to 1500 Pg. Of this, ∼500 Pg is in non-permafrost soils, seasonally thawed in the active layer or in deeper taliks, while ∼800 Pg is perennially frozen. This represents a substantial ∼300 Pg lowering of the estimated perennially frozen SOC stock compared to previous estimates.

Date: 1969-01-01

Creator: Richard V. West

Access: Open access

Catalog of an exhibition held at the Bowdoin College Museum of Art.

Date: 2011-01-01

Creator: Diana K. Tuite

Access: Open access

Catalog of an exhibition held April 12-July 1, 2012, at the Bowdoin College Museum of Art, Brunswick, Maine. Includes essay "Conspiring forms" by Diana Tuite (p. 2-3)

Date: 1995-01-01

Access: Open access

Date: 1977-01-01

Creator: William H. Barker

Access: Open access

Iii this paper we show that the structure of the Bergman and Szegö kernel functions is especially simple on domains with hyperelliptic double. Each such domain is conformally equivalent to the exterior of a system of slits taken from the real axis, and on such domains the Bergman kernel function and its adjoint are essentially the same, while the Szegö kernel function and its adjoint are elementary and can be written in a closed form involving nothing worse than fourth roots of polynomials. Additionally, a number of applications of these results are obtained. © 1977 American Mathematical Society.

Date: 2014-01-01

Creator: Hannah E. Reese, Lawrence Scahill, Alan L. Peterson, Katherine Crowe, Douglas W., Woods, John Piacentini, John T. Walkup, Sabine Wilhelm

Access: Open access

In addition to motor and/or vocal tics, many individuals with Tourette syndrome (TS) or chronic tic disorder (CTD) report frequent, uncomfortable sensory phenomena that immediately precede the tics. To date, examination of these premonitory sensations or urges has been limited by inconsistent assessment tools. In this paper, we examine the psychometric properties of a nine-item self-report measure, the Premonitory Urge to Tic Scale (PUTS) and examine the characteristics and correlates of the premonitory urge to tic in a clinical sample of 122 older adolescents and adults with TS or CTD. The PUTS demonstrated adequate internal consistency, temporal stability, and concurrent validity. Premonitory urges were endorsed by the majority of individuals. Most individuals reported some relief from the urges after completing a tic and being able to stop their tics even if only temporarily. Degree of premonitory urges was not significantly correlated with age, and we did not observe any gender differences. Degree of premonitory urges was significantly correlated with estimated IQ and tic severity, but not severity of comorbid obsessive-compulsive disorder or attention-deficit hyperactivity disorder. Also, it was not related to concomitant medication status. These findings represent another step forward in our understanding of the premonitory sensations associated with TS and CTD. © 2013.

Date: 2016-05-01

Creator: Amanda J. Blick, Ilana Mayer-Hirshfeld, Beatriz R. Malibiran, Matthew A. Cooper, Pieter A., Martino, Justine E. Johnson, Jack R. Bateman

Access: Open access

The interphase nucleus is organized such that genomic segments interact in cis, on the same chromosome, and in trans, between different chromosomes. In Drosophila and other Dipterans, extensive interactions are observed between homologous chromosomes, which can permit enhancers and promoters to communicate in trans. Enhancer action in trans has been observed for a handful of genes in Drosophila, but it is as yet unclear whether this is a general property of all enhancers or specific to a few. Here, we test a collection of well-characterized enhancers for the capacity to act in trans. Specifically, we tested 18 enhancers that are active in either the eye or wing disc of third instar Drosophila larvae and, using two different assays, found evidence that each enhancer can act in trans. However, the degree to which trans-action was supported varied greatly between enhancers. Quantitative analysis of enhancer activity supports a model wherein an enhancer’s strength of transcriptional activation is a major determinant of its ability to act in trans, but that additional factors may also contribute to an enhancer’s trans-activity. In sum, our data suggest that a capacity to activate a promoter on a paired chromosome is common among Drosophila enhancers.

Date: 2011-06-01

Creator: David K. Hecht

Access: Open access

This article uses the voluminous public discourse around Rachel Carson and her controversial bestseller Silent Spring to explore Americans' views on science and scientists. Carson provides a particularly interesting case study because of intense and public debates over whether she was a scientist at all, and therefore whether her book should be granted legitimacy as science. Her career defied easy classification, as she acted variously as writer, activist, and environmentalist in addition to scientist. Defending her work as legitimate science, which many though not all commentators did, therefore became an act of defining what both science and scientists could and should be. This article traces the variety of nonscientific images and narratives readers and writers assigned to Carson, such as "reluctant crusader" and "scientist-poet." It argues that nonscientific attributes were central to legitimating her as both admirable person and admirable scientist. It explores how debates over Silent Spring can be usefully read as debates over the desirability of putatively nonscientific attributes in the professional work of a scientist. And it examines the nature of Carson's very democratized image for changing notions of science and scientists in 1960s United States politics and culture. © 2011 by the Regents of the University of California. All rights reserved.

Date: 2007-12-01

Creator: Michael M. Franz, Travis N. Ridout

Access: Open access

Well over $1 billion was spent on televised political advertising in the U.S. in 2004. Given the ubiquity of the 30 second spot, one might presume that ads must affect viewers' vote choices. Somewhat surprisingly, though, scholars have yet to make much progress in confirming this claim. In this paper, we leverage a comprehensive dataset that tracks political ads in the nation's top media markets and a survey of presidential and U.S. Senate voters in 2004. We ask whether exposure to presidential and Senate advertising influences voters' evaluations of candidates and the choices that they make at the ballot box. In the end, we find considerable evidence that advertising persuades-and that its impact varies depending on the characteristics of the viewer. © 2007 Springer Science+Business Media, LLC.

Date: 2004-09-01

Creator: Travis N. Ridout, Dhavan V. Shah, Kenneth M. Goldstein, Michael M. Franz

Access: Open access

Scholars employ various methods to measure exposure to televised political advertising but often arrive at conflicting conclusions about its impact on the thoughts and actions of citizens. We attempt to clarify one of these debates while validating a parsimonious measure of political advertising exposure. To do so, we assess the predictive power of six different measurement approaches - from the simple to the complex - on learning about political candidates. Two datasets are used in this inquiry: (1) geo-coded political advertising time-buy data, and (2) a national panel study concerning patterns of media consumption and levels of political knowledge. We conclude that many traditional methods of assessing exposure are flawed. Fortunately, there is a relatively simple measure that predicts knowledge about information featured in ads. This measure involves combining a tally of the volume of advertisements aired in a market with a small number of survey questions about the television viewing habits of geo-coded respondents.

Date: 2013-03-01

Creator: William R. Jackman, Shelby H. Davies, David B. Lyons, Caitlin K. Stauder, Benjamin R., Denton-Schneider, Andrea Jowdry, Sharon R. Aigler, Scott A. Vogel, David W. Stock

Access: Open access

Teeth with two or more cusps have arisen independently from an ancestral unicuspid condition in a variety of vertebrate lineages, including sharks, teleost fishes, amphibians, lizards, and mammals. One potential explanation for the repeated origins of multicuspid teeth is the existence of multiple adaptive pathways leading to them, as suggested by their different uses in these lineages. Another is that the addition of cusps required only minor changes in genetic pathways regulating tooth development. Here we provide support for the latter hypothesis by demonstrating that manipulation of the levels of Fibroblast growth factor (Fgf) or Bone morphogenetic protein (Bmp) signaling produces bicuspid teeth in the zebrafish (Danio rerio), a species lacking multicuspid teeth in its ancestry. The generality of these results for teleosts is suggested by the conversion of unicuspid pharyngeal teeth into bicuspid teeth by similar manipulations of the Mexican Tetra (Astyanax mexicanus). That these manipulations also produced supernumerary teeth in both species supports previous suggestions of similarities in the molecular control of tooth and cusp number. We conclude that despite their apparent complexity, the evolutionary origin of multicuspid teeth is positively constrained, likely requiring only slight modifications of a pre-existing mechanism for patterning the number and spacing of individual teeth. © 2013 Wiley Periodicals, Inc.

Date: 2013-01-01

Creator: Collin S. Roesler, Andrew H. Barnard

Access: Open access

The pigment absorption peak in the red waveband observed in phytoplankton and particulate absorption spectra is primarily associated with chlorophyll-a and exhibits much lower pigment packaging compared to the blue peak. The minor contributions to the signature by accessory pigments can be largely removed by computing the line height absorption at 676 nm above a linear background between approximately 650 nm and 715 nm. The line height determination is also effective in removing the contributions to total or particulate absorption by colored dissolved organic matter and non-algal particles, and is relatively independent of the effects of biofouling. The line height absorption is shown to be significantly related to the extracted chlorophyll concentration over a large range of natural optical regimes and diverse phytoplankton cultures. Unlike the in situ fluorometric method for estimating chlorophyll, the absorption line height is not sensitive to incident irradiance, in particular non-photochemical quenching. The combination of the two methods provides a combination of robust phytoplankton biomass estimates, pigment based taxonomic information and a means to estimate the photosynthetic parameter, , the irradiance at which photosynthesis transitions from light limitation to light saturation. © 2013 The Authors. E K

Date: 2020-01-01

Creator: Mac Brower

Access: Open access

This is a poem I composed while stay-at-home orders were being issued nationwide. I wrote it shortly after leaving my home in Washington, DC to live with my parents in North Carolina. The author is an alumnus from the class of 2018.

Date: 2019-11-09

Creator: Saira Toppin

Access: Open access

Saira Toppin ’09 discusses her upbringing in Brooklyn, New York, and how that made for a challenging transition to Brunswick, Maine. She shares how a few juniors mentored her during her first year, which helped Toppin adjust to Bowdoin. She credits this mentorship with encouraging her to carve out space for herself on campus as an Afro-Latina and also to look out for others once she became an upperclassman. She shares stories from her time on the boards of both the African American Society and the Latin American Students Organization (LASO). As co-president of LASO during her junior and senior year, Toppin helped the organization have an impact on campus by organizing Latin American Heritage Month event Fall. She made sure to mentor underclassman so that they could run the club in her absence and considers LASO to be her legacy.

Date: 2021-01-01

Creator: Anonymous

Access: Open access

This is a response to the Documenting Bowdoin & COVID-19 Reflections Questionnaire. The questionnaire was created in March 2021 by staff of Bowdoin's George J. Mitchell Department of Special Collections & Archives. The author is a member of Bowdoin's faculty.

Date: 2004-01-01

Creator: Paul Freedman, Michael Franz, Kenneth Goldstein

Access: Open access

Concern about the state of American democracy is a staple of political science and popular commentary. Critics warn that levels of citizen participation and political knowledge are disturbingly low and that seemingly ubiquitous political advertising is contributing to the problem. We argue that political advertising is rife with both informational and emotional content and actually contributes to a more informed, more engaged, and more participatory citizenry. With detailed advertising data from the 2000 election, we show that exposure to campaign advertising produces citizens who are more interested in the election, have more to say about the candidates, are more familiar with who is running, and ultimately are more likely to vote. Importantly, these effects are concentrated among those citizens who need it most: those with the lowest pre-existing levels of political information.

Date: 2009-06-01

Creator: Yoshiyuki Yamamoto, Mardi S. Byerly, William R. Jackman, William R. Jeffery

Access: Open access

This study addresses the role of sonic hedgehog (shh) in increasing oral-pharyngeal constructive traits (jaws and taste buds) at the expense of eyes in the blind cavefish Astyanax mexicanus. In cavefish embryos, eye primordia degenerate under the influence of hyperactive Shh signaling. In concert, cavefish show amplified jaw size and taste bud numbers as part of a change in feeding behavior. To determine whether pleiotropic effects of hyperactive Shh signaling link these regressive and constructive traits, shh expression was compared during late development of the surface-dwelling (surface fish) and cave-dwelling (cavefish) forms of Astyanax. After an initial expansion along the midline of early embryos, shh was elevated in the oral-pharyngeal region in cavefish and later was confined to taste buds. The results of shh inhibition and overexpression experiments indicate that Shh signaling has an important role in oral and taste bud development. Conditional overexpression of an injected shh transgene at specific times in development showed that taste bud amplification and eye degeneration are sensitive to shh overexpression during the same early developmental period, although taste buds are not formed until much later. Genetic crosses between cavefish and surface fish revealed an inverse relationship between eye size and jaw size/taste bud number, supporting a link between oral-pharyngeal constructive traits and eye degeneration. The results suggest that hyperactive Shh signaling increases oral and taste bud amplification in cavefish at the expense of eyes. Therefore, selection for constructive oral-pharyngeal traits may be responsible for eye loss during cavefish evolution via pleiotropic function of the Shh signaling pathway. © 2009 Elsevier Inc. All rights reserved.

Date: 1880-01-01

Access: Open access

Date: 2013-06-11

Creator: Kent Kovacs, Stephen Polasky, Erik Nelson, Bonnie L. Keeler, Derric, Pennington, Andrew J. Plantinga, Steven J. Taff

Access: Open access

We evaluate the return on investment (ROI) from public land conservation in the state of Minnesota, USA. We use a spatially-explicit modeling tool, the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST), to estimate how changes in land use and land cover (LULC), including public land acquisitions for conservation, influence the joint provision and value of multiple ecosystem services. We calculate the ROI of a public conservation acquisition as the ratio of the present value of ecosystem services generated by the conservation to the cost of the conservation. For the land scenarios analyzed, carbon sequestration services generated the greatest benefits followed by water quality improvements and recreation opportunities. We found ROI values ranged from 0.21 to 5.28 depending on assumptions about future land use change, service values, and discount rate. Our study suggests conservation is a good investment as long as investments are targeted to areas with low land costs and high service values. © 2013 Kovacs et al.

Date: 2019-05-01

Creator: Connor Rockett

Access: Open access

Focusing on sub-Saharan Africa, this study tests the hypothesis that state intervention in agrarian economies causes peasant movements to engage in broad-based contention, on regional and national levels. The study traces the connections between government land and agricultural institutions and the characteristics of rural movements that make claims on them. Case studies of regions of Tanzania, Senegal, Côte d’Ivoire, and Ethiopia show the ways in which rural movements are constructed in response to the political and social environments in which they arise. That is, the comparisons demonstrate that the character of political authority and social organization are important determinants of the form taken by peasant movements.