Showing 201 - 210 of 583 Items

"You get a lot besides just affordable housing; you get a support network”: Community Engagement in Sustainable Affordable Housing Development This record is embargoed.
- Embargo End Date: 2029-05-16
Date: 2024-01-01
Creator: Katie Draeger
Access: Embargoed
Antimicrobial Peptides (AMPs) in the Lobster, Homarus Americanus: Isolation and Activity
Date: 2021-01-01
Creator: Ruby Chimereucheya Ahaiwe
Access: Open access
- The American lobster Homarus americanus uses its innate immune system for protection against foreign bodies and diseases. Hemocytes in the innate immune system are responsible for the rapid and effective cellular response against pathogens and infections observed in lobsters. These hemocytes, particularly semi-granulocytes and granulocytes, store antimicrobial peptides (AMPs) which specifically target and destroy microbes. Hemocyte samples from the American lobster Homarus americanus hemolymph or circulatory fluid, mixed and fractionated into separated semi-granular and granular cell samples, were analyzed for possible AMP presence. A defensin AMP, Hoa-D1, (SYVRSCSSNGGDCVYRCYGNIINGACSGSRVCCRSGGGYamide; with C representing a cysteine participating in a disulfide bond) was successfully isolated and identified by mass using reversed-phase high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS/MS). Preliminary results also show the defensin AMP to be concentrated in the semi-granulocytes and granulocytes.Hoa-D1 was isolated via HPLC fractionation. Isolated Hoa-D1 and semi-granular and granular hemocyte extracts were tested for bioactivity against the gram-negative bacteria, Escherichia coli, using the Kirby-Bauer disk diffusion assay. The assay did not show any activity, an outcome attributed to concentrations of the AMP that were too low to have any antimicrobial effect on E. coli. Subsequent work on this study should involve increasing the concentration of Hoa-D1 in test samples. Studying function of AMPs in the American lobster can provide more information on the depth of their cellular immune responses in other crustaceans, and possibly contribute to the development of novel antibiotics for treating diseases in humans.
Assigning Legal Punishment: Individual Differences in Justice Sensitivity and Selective Attention
Date: 2015-05-01
Creator: Emily C. Weinberger
Access: Open access
- Selective attention and justice sensitivity (JS), a personality trait reflecting individual differences in perceptions of injustice, have been shown to affect how people assign punishments. In the present study peoples’ decision-making processes were investigated to better understand the inconsistencies in legal punishment decisions, particularly when using retributive versus restorative justice. Subjects participated in three phases of the experiment. First, subjects completed a justice sensitivity scale and then rated the appropriateness of punishment options to handle a criminal scenario. Second, participants’ selective attention was indicated by their recall of pertinent features from three ambiguous criminal scenarios. Finally, participants were primed with either restorative justice or neutral control words, and rated the appropriateness of punishment options to handle a new criminal scenario. Results revealed no significant associations between JS and ratings of punishment options, although patterns suggested negative relationships between observer JS and retributive justice ratings, and victim JS and restorative justice ratings. Results did show a significant effect of JS in predicting the facts remembered, such that as observer JS increased, more restorative justice facts were recalled, and as victim JS increased, fewer restorative justice facts were recalled. No significant effect of the restorative justice prime was observed. These results may contribute to better understanding of criminal justice policy in the United States.
Site, Power, and Experience: Three Contemporary Installation Works on Global Mobility
Date: 2021-01-01
Creator: Xiyin Sabrina Lin
Access: Open access
- This Honors Project investigates the themes of immigration, space, and mobility through the lens of contemporary installation art. It addresses a brief history of global contemporary art, arguing that art of the past two decades has been shaped by preoccupations with and tensions surrounding space. Using the works of Yanagi Yukinori, Alfredo Jaar, and Doris Salcedo as case studies, the essay analyzes how artists use the medium of installation to address institutional history, contemporary geopolitics, as well as individual and collective experience. It interrogates the different aspects of installation art, including temporality, site-specificity, and the use of language, to demonstrate how the medium allows artists to use their own position in the system to critique its inherent limitations.
Sensitivity Analysis of Basins of Attraction for Gradient-Based Optimization Methods
Date: 2022-01-01
Creator: Gillian King
Access: Open access
- This project is an analysis of the effectiveness of five distinct optimization methods in their ability in producing clear images of the basins of attraction, which is the set of initial points that approach the same minimum for a given function. Basin images are similar to contour plots, except that they depict the distinct regions of points--in unique colors--that approach the same minimum. Though distinct in goal, contour plots are useful to basin research in that idealized basin images can be inferred from the steepness levels and location of extrema they depict. Effectiveness of the method changes slightly depending on the function, but is generally defined as how closely the basin image models contour information on where the true minima are located, and by the clarity of the resulting image in depicting well-defined regions. The methods are tested on four distinct functions which were chosen to assess how each method performs in the presence of various challenges. This project ranks the five methods for their overall effectiveness and consistency across the four functions, and also analyzes the sensitivity of the methods when small changes are made to the function. In general, less sensitive and consistently effective methods are more applicable and reliable in applied optimization research.
The Best and the Brightest?: Race, Class, and Merit in America's Elite Colleges
Date: 2017-05-01
Creator: Walter Chacon
Access: Open access

Fluorescent Sugar Analogs as Probes for Bacterial Monosaccharide Uptake Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2024-01-01
Creator: Foje-Geh Robert Tendoh
Access: Access restricted to the Bowdoin Community
Seize the Memes: Community, Personal Expression, and Everyday Feminist Politics Through Instagram Memes
Date: 2018-01-01
Creator: Tessa Westfall
Access: Open access

Clam shells and sea temperature: Evaluation of the oxygen isotopic climate proxy in Arctica islandica and development of a shell-derived sea temperature reconstruction from Isle au Haut, Maine Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2024-01-01
Creator: Brielle Martin
Access: Access restricted to the Bowdoin Community
Africa and the International Criminal Court: Behind the Backlash and Toward Future Solutions
Date: 2017-05-01
Creator: Marisa O'Toole
Access: Open access
- Fifteen years into its operation as the preeminent international institution charged with the prosecution of the most serious international crimes, the International Criminal Court (ICC) has faced and continues to face intense backlash from the African continent. Once the Court’s most fervent advocates, many African leaders now lambast the ICC. In recent months, three African countries and the African Union en masse have attempted withdrawal from the Court, thus pushing the ICC-Africa relationship into the international spotlight as a topic of acute global interest. This paper seeks to explore the critiques behind this backlash through both a historical and present-day lens, as well as from the perspectives of African leaders, victims-locals, and civil society actors. In doing so, it investigates historical critiques of the ICTY and ICTR, concerns raised during the Rome Statute negotiations, current African leader perspectives as viewed through the case studies of Darfur, Kenya, Uganda, and the AU-ICC relationship, and present African victim-local and civil society opinions of the Court. By understanding the current and multi-faceted African opposition to the ICC and such criticisms’ historical roots, as well as the pockets of hope for the Court within Africa, this analysis reveals the ICC’s main challenges in its relationship with the African continent. With such hurdles unveiled, the ICC can pursue several strategies, located primarily on the state and individual levels, in its endeavor to address these important critiques and regain African support.