Showing 2351 - 2360 of 5714 Items

Bowdoin Alumnus Volume 14 (1939-1940)

Date: 1940-01-01

Access: Open access



Illustrated Handbook of the Bowdoin College Museum of Fine Arts in the Walker Art Building

Date: 1950-01-01

Access: Open access

"Photography by Stephen E. Merrill, Brunswick, Maine"--T.p. verso


Destabilization of cortical dendrites and spines by BDNF

Date: 1999-01-01

Creator: Hadley Wilson Horch, Alex Krüttgen, Stuart D. Portbury, Lawrence C. Katz

Access: Open access

Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over 24-48 hr, coexpressing BDNF elicited dramatic sprouting of basal dendrites, accompanied by a regression of dendritic spines. Compared to GFP-transfected controls, the newly formed dendrites and spines were highly unstable. Experiments utilizing Trk receptor bodies, K252a, and overexpression of nerve growth factor (NGF) demonstrated that these effects were mediated by secreted BDNF interacting with extracellular TrkB receptors. Thus, BDNF induces structural instability in dendrites and spines, which, when restricted to particular portions of a dendritic arbor, may help translate activity patterns into specific morphological changes.


A New Beginning

Date: 2007-01-01

Access: Open access



Catalogue of Etchings Presented to Bowdoin College by Charles A. Coffin of New York, May, 1923

Date: 1923-01-01

Access: Open access

Contains biographical sketches.


Deciphering the bacterial glycocode: Recent advances in bacterial glycoproteomics

Date: 2013-02-01

Creator: Scott A. Longwell, Danielle H. Dube

Access: Open access

Bacterial glycoproteins represent an attractive target for new antibacterial treatments, as they are frequently linked to pathogenesis and contain distinctive glycans that are absent in humans. Despite their potential therapeutic importance, many bacterial glycoproteins remain uncharacterized. This review focuses on recent advances in deciphering the bacterial glycocode, including metabolic glycan labeling to discover and characterize bacterial glycoproteins, lectin-based microarrays to monitor bacterial glycoprotein dynamics, crosslinking sugars to assess the roles of bacterial glycoproteins, and harnessing bacterial glycosylation systems for the efficient production of industrially important glycoproteins. © 2012 Elsevier Ltd.


Bowdoin Orient, v. 136, no. 1

Date: 2006-09-08

Access: Open access



Bowdoin Orient, v. 136, no. 24

Date: 2007-05-04

Access: Open access



Bowdoin Orient, v. 137, no. 1

Date: 2007-09-07

Access: Open access



Bowdoin Orient, v. 133, no. 22

Date: 2004-04-30

Access: Open access

There are two volumes numbered 133. This is the second.