Showing 3331 - 3340 of 5713 Items
Date: 2012-08-30
Creator: Mary Rogalski
Access: Open access
Date: 2000-04-01
Creator: William R. Jackman, James A. Langeland, Charles B. Kimmel
Access: Open access
- The vertebrate embryonic hindbrain is segmented into rhombomeres. Gene expression studies suggest that amphioxus, the closest invertebrate relative of vertebrates, has a hindbrain homolog. However, this region is not overtly segmented in amphioxus, raising the question of how hindbrain segmentation arose in chordate evolution. Vertebrate hindbrain segmentation includes the patterning of cranial motor neurons, which can be identified by their expression of the LIM-homeodomain transcription factor islet1. To learn if the amphioxus hindbrain homolog is cryptically segmented, we cloned an amphioxus gene closely related to islet1, which we named simply islet. We report that amphioxus islet expression includes a domain of segmentally arranged cells in the ventral hindbrain homolog. We hypothesize that these cells are developing motor neurons and reveal a form of hindbrain segmentation in amphioxus. Hence, vertebrate rhombomeres may derive from a cryptically segmented brain present in the amphioxus/vertebrate ancestor. Other islet expression domains provide evidence for amphioxus homologs of the pineal gland, adenohypophysis, and endocrine pancreas. Surprisingly, homologs of vertebrate islet1-expressing spinal motor neurons and Rohon-Beard sensory neurons appear to be absent. (C) 2000 Academic Press.
Date: 2016-02-25
Creator: B. Zorina Khan
Access: Open access
- The French economy has been criticized for a lack of integration of women in business and for the prevalence of inefficient family firms. A sample drawn from patent and exhibition records is used to examine the role of women in enterprise and invention in France. Middle-class women were extensively engaged in entrepreneurship and innovation, and the empirical analysis indicates that their commercial efforts were significantly enhanced by association with family firms. Such formerly invisible achievements suggest a more productive role for family-based enterprises, as a means of incorporating relatively disadvantaged groups into the market economy as managers and entrepreneurs. This business model .... melds entrepreneurial passion with a long family tradition. - Wendel Company (1704-2014) 1
Date: 1996-01-01
Creator: Justin G. Schuetz
Access: Open access
- Accompanies an exhibition held at the Bowdoin College Museum of Art from April 17 through June 2, 1996. "This brochure is published with funding from the Andrew W. Mellon Foundation."--Colophon
Date: 2013-10-28
Creator: Yao Tang, Yoshinori Kurokawa, Jiaren Pang
Access: Open access
- We construct a dynamic Ricardian model of trade with money and nominal exchange rate. The model implies that the nominal wages of the trading countries are more likely to exhibit stronger positive comovements when the countries fix their bilateral exchange rates. Panel regression results based on data from OECD countries from 1973 to 2012 suggest that countries in the European Monetary Union (EMU) experienced stronger positive wage comovements with their main trade partners. When we restrict the regression to the subsample of the EMU countries, we find a significant increase in wage comovements after these countries joined the EMU in 1999 compared to the pre-euro era. In comparison, when the sample is restricted to the non-EMU countries, we find no evidence that non-currency union pegs affected the wage comovements.
Date: 2014-01-01
Creator: Anja Forche
Access: Open access
- Pathogenic fungi encounter many different host environments to which they must adapt rapidly to ensure growth and survival. They also must be able to cope with alterations in established niches during long-term persistence in the host. Many eukaryotic pathogens have evolved a highly plastic genome, and large-scale chromosomal changes including aneuploidy, and loss of heterozygosity (LOH) can arise under various in vitro and in vivo stresses. Both aneuploidy and LOH can arise quickly during a single cell cycle, and it is hypothesized that they provide a rapid, albeit imprecise, solution to adaptation to stress until better and more refined solutions can be acquired by the organism. While LOH, with the extreme case of haploidization in Candida albicans, can purge the genome from recessive lethal alleles and/or generate recombinant progeny with increased fitness, aneuploidy, in the absence or rarity of meiosis, can serve as a non-Mendelian mechanism for generating genomic variation. © Springer Science+Business Media 2014.
Date: 2017-01-01
Creator: Emilie Dassié, Kristine Delong, Hali Kilbourne, Branwen Williams, Nerilie, Abram, Logan Brenner, Chloé Brahmi, Kim M. Cobb, Thierry Corrège, Delphine Dissard, Julien Emile-Geay, Heitor Evangelista, Michael N. Evans, Jesse Farmer, Thomas Felis, Michael Gagan, David P. Gillikin, Nathalie Goodkin, Myriam Khodri, Ana Carolina Lavagnino, Michèle Lavigne, Claire Lazareth, Braddock Linsley, Janice Lough, Helen McGregor, Intan S. Nurhati, Gilman Ouellette, Laura Perrin, Maureen Raymo, Brad Rosenheim, Michael Sandstrom, Bernd R. Schöne
Access: Open access
Date: 2021-01-01
Creator: Anonymous
Access: Open access
- This is a response to the Documenting Bowdoin & COVID-19 Reflections Questionnaire. The questionnaire was created in March 2021 by staff of Bowdoin's George J. Mitchell Department of Special Collections & Archives. Author is class of 2024.