Showing 3451 - 3460 of 5708 Items
Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila
Date: 2021-06-01
Creator: Myron Child, Jack R. Bateman, Amir Jahangiri, Armando Reimer, Nicholas C., Lammers, Nica Sabouni, Diego Villamarin, Grace C. McKenzie-Smith, Justine E. Johnson, Daniel Jost, Hernan G. Garcia
Access: Open access
- 3D eukaryotic genome organization provides the structural basis for gene regulation. In Drosophila melanogaster, genome folding is characterized by somatic homolog pairing, where homologous chromosomes are intimately paired from end to end; however, how homologs identify one another and pair has remained mysterious. Recently, this process has been proposed to be driven by specifically interacting “buttons” encoded along chromosomes. Here, we turned this hypothesis into a quantitative biophysical model to demonstrate that a button-based mechanism can lead to chromosome-wide pairing. We tested our model using live-imaging measurements of chromosomal loci tagged with the MS2 and PP7 nascent RNA labeling systems. We show solid agreement between model predictions and experiments in the pairing dynamics of individual homologous loci. Our results strongly support a button-based mechanism of somatic homolog pairing in Drosophila and provide a theoretical framework for revealing the molecular identity and regulation of buttons.
Catalogue of the Marbles, Gems, Bronzes, and Coins of the Warren Collection of Greek and Roman Antiquities
Date: 1934-01-01
Access: Open access
- Descriptive catalogue of the Warren Classical Collection of Bowdoin College.
Robert Birmelin: Recent Paintings, Maine and New York
Date: 1980-01-01
Access: Open access
- Catalogue of an exhibition held at Bowdoin College Museum of Art, Mar. 14 to May 25, 1980.
Recent Acquisitions, 1961-1968
Date: 1968-01-01
Access: Open access
- "One thousand copies of this catalogue were set in Linotype Janson and printed by the Anthoensen Press, Portland, Maine. Design by Thomas Cornell"--P. [28]
Handbook of the Collections
Date: 1981-01-01
Creator: Margaret Burke
Access: Open access
- "Type composition by the Anthoensen Press."
Descriptive Catalogue of the Paintings, Sculpture and Drawings and of the Walker Collection
Date: 1930-01-01
Access: Open access
- "A considerably modified reprint of the preceding edition. [Descriptive catalogue of the art collections of Bowdoin college] compiled by the late Professor Henry Johnson along with a verbatim reprint of his descriptive catalogue of the Bowdoin collection of old masters' drawings."--Prefatory note