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Miniature of Bowdoin Alumnus Volume 22 (1947-1948)
Bowdoin Alumnus Volume 22 (1947-1948)

Date: 1948-01-01

Access: Open access

Miniature of Messenger RNA transport in the opportunistic fungal pathogen Candida albicans
Messenger RNA transport in the opportunistic fungal pathogen Candida albicans

Date: 2017-12-01

Creator: Anne E. McBride

Access: Open access

Candida albicans, a common commensal fungus, can cause disease in immunocompromised hosts ranging from mild mucosal infections to severe bloodstream infections with high mortality rates. The ability of C. albicans cells to switch between a budding yeast form and an elongated hyphal form is linked to pathogenicity in animal models. Hyphal-specific proteins such as cell-surface adhesins and secreted hydrolases facilitate tissue invasion and host cell damage, but the specific mechanisms leading to asymmetric protein localization in hyphae remain poorly understood. In many eukaryotes, directional cytoplasmic transport of messenger RNAs that encode asymmetrically localized proteins allows efficient local translation at the site of protein function. Over the past two decades, detailed mechanisms for polarized mRNA transport have been elucidated in the budding yeast Saccharomyces cerevisiae and the filamentous fungus Ustilago maydis. This review highlights recent studies of RNA-binding proteins in C. albicans that have revealed intriguing similarities to and differences from known fungal mRNA transport systems. I also discuss outstanding questions that will need to be answered to reach an in-depth understanding of C. albicans mRNA transport mechanisms and the roles of asymmetric mRNA localization in polarized growth, hyphal function, and virulence of this opportunistic pathogen.
Miniature of Tainted resurrection: metal pollution is linked with reduced hatching and high juvenile mortality inDaphniaegg banks
Tainted resurrection: metal pollution is linked with reduced hatching and high juvenile mortality inDaphniaegg banks

Date: 2015-05-01

Creator: Mary A. Rogalski

Access: Open access

Miniature of "COVID-19 Pandemic May 2020 Portfolio" by Gemma Jyothika Kelton (Class of 2022)
"COVID-19 Pandemic May 2020 Portfolio" by Gemma Jyothika Kelton (Class of 2022)

Date: 2020-01-01

Creator: Gemma Jyothika Kelton

Access: Open access

I was a student of this class (GSWS 2261: Gender, Film, and Consumer Culture) that examined the impact of COVID-19 on not only our smaller Bowdoin community, but also the larger global society as a whole. Author is class of 2022.
Miniature of Bowdoin College - Medical School of Maine Catalogue (1821 Feb)
Bowdoin College - Medical School of Maine Catalogue (1821 Feb)

Date: 1821-02-01

Access: Open access

Medical Institution of Maine at Bowdoin College
Miniature of GREEN-PSO: Conserving function evaluations in Particle Swarm Optimization
GREEN-PSO: Conserving function evaluations in Particle Swarm Optimization

Date: 2013-11-18

Creator: Stephen M. Majercik

Access: Open access

In the Particle Swarm Optimization (PSO) algorithm, the expense of evaluating the objective function can make it difficult, or impossible, to use this approach effectively; reducing the number of necessary function evaluations would make it possible to apply the PSO algorithm more widely. Many function approximation techniques have been developed that address this issue, but an alternative to function approximation is function conservation. We describe GREEN-PSO (GR-PSO), an algorithm that, given a fixed number of function evaluations, conserves those function evaluations by probabilistically choosing a subset of particles smaller than the entire swarm on each iteration and allowing only those particles to perform function evaluations. The "surplus" of function evaluations thus created allows a greater number of particles and/or iterations. In spite of the loss of information resulting from this more parsimonious use of function evaluations, GR-PSO performs as well as, or better than, the standard PSO algorithm on a set of six benchmark functions, both in terms of the rate of error reduction and the quality of the final solution.
Miniature of Galileo, poetry, and patronage: Iulio strozzi's venetia edificata and the lace of galileo in seventeenth-century talian poetry
Galileo, poetry, and patronage: Iulio strozzi's venetia edificata and the lace of galileo in seventeenth-century talian poetry

Date: 2013-12-01

Creator: Crystal Hall

Access: Open access

The Venetian poet and librettist Giulio Strozzi (1583 -1652) spent much of his career glorifying he Serenissima through a series of theatrical pieces. His only epic poem, the Venetia edificata (1621, 1624), while ostensibly a celebration of the republic, shows a level of commitment to alileo Galilei (1564 -1643) and to Galileo's science that is unique among poets of the time, enetian or otherwise. It is the apex of Strozzi's artistic project to incorporate Galileo's discoveries nd texts into poetic works. The Venetia edificata also represents the culmination of a fifteen-year ffort to gain patronage from the Medici Grand Dukes in Florence. While the first, incomplete ersion is dedicated to the Venetian Doge, the second, finished version is dedicated to Grand DukeFerdinando II de' Medici of Florence. More than a decade after Galileo's departure from the eneto to Florence, Strozzi cites from Galileo's early works, creates a character inspired by Galileo, ncorporates the principles of Galileo's science into the organizing structure of the poem, and nswers one of Galileo's loudest complaints about Torquato Tasso's Jerusalem Delivered (1581). trozzi's strategies both in writing the Venetia edificata and in seeking patronage for it underscore he ambivalent response to Galileo in contemporary poetry.
Miniature of "How Are You?" by Kristin D. Forner (Class of 1997)
"How Are You?" by Kristin D. Forner (Class of 1997)

Date: 2020-01-01

Creator: Kristin D. Forner, MD

Access: Open access

My name is Kristin Forner and I am the Palliative Care Program Director and Bioethics Co-Chair at one of the MedStar Hospitals hardest hit by COVID-19 in the Washington, DC area. Our patient population is predominantly Black and Hispanic. I am also a foster mother. This essay is about my experience as a frontline medical provider wrestling with racial disparity and the weight of so much grief. The author is an alumna from the class of 1997.
Miniature of What some ghosts don't know: Spectral incognizance and the horror film
What some ghosts don't know: Spectral incognizance and the horror film

Date: 2009-01-01

Creator: Aviva Briefel

Access: Open access

Miniature of Art of American Furniture: A Portfolio of Furniture in the Collections of the Bowdoin College Museum of Art
Art of American Furniture: A Portfolio of Furniture in the Collections of the Bowdoin College Museum of Art

Date: 1974-01-01

Creator: William Pooley

Access: Open access

Catalog of an exhibition April 7-May 12, 1974.

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