Showing 4621 - 4630 of 5701 Items
Information-Processing Approaches to Understanding Anxiety Disorders
Date: 2008-09-04
Creator: Richard J. McNally, Hannah E. Reese
Access: Open access
- Experimental psychopathologists have used cognitive psychology paradigms to elucidate information-processing biases in the anxiety disorders. A vast literature now suggests that patients with anxiety disorders are characterized by an attentional bias for threatening information and a bias toward threatening interpretations of ambiguous information. A memory bias favoring recall of threatening information occurs in panic disorder, but rarely in other anxiety disorders. New treatments involving the experimental modification of cognitive biases are promising.
Maintenance of dynamic strain similarity and environmental stres factor in different flow habitats: Thallus allometry and material properties of a giant kelp
Date: 1994-01-01
Creator: A. S. Johnson, M. A.R. Koehl
Access: Open access
Telling Toggles: Netsuke in Context
Date: 2002-01-01
Creator: Christine L. Paglia
Access: Open access
- "This brochure accompanies an exhibition of the same name at the Bowdoin College Museum of Art from April 11 through June 9, 2002"--P. [2] of cover
A dominant allele of arabidopsis pectin-binding wall-associated kinase induces a stress response suppressed by MPK6 but not MPK3 mutations
Date: 2012-01-01
Creator: Bruce D. Kohorn, Susan L. Kohorn, Tanya Todorova, Gillian Baptiste, Kevin, Stansky, Meghan McCullough
Access: Open access
- The plant cell wall is composed of a matrix of cellulose fibers, flexible pectin polymers, and an array of assorted carbohydrates and proteins. The receptor-like Wall-Associated Kinases (WAKs) of Arabidopsis bind pectin in the wall, and are necessary both for cell expansion during development and for a response to pathogens and wounding. Mitogen Activated Protein Kinases (MPKs) form a major signaling link between cell surface receptors and both transcriptional and enzyme regulation in eukaryotes, and Arabidopsis MPK6 and MPK3 indeed have important roles in development and the response to stress and pathogens. A dominant allele of WAK2 requires kinase activity and activates a stress response that includes an increased ROS accumulation and the up-regulation of numerous genes involved in pathogen resistance, wounding, and cell wall biogenesis. This dominant allele requires a functional pectin binding and kinase domain, indicating that it is engaged in a WAK signaling pathway. A null mutant of the major plasma membrane ROS-producing enzyme complex, rbohd/f does not suppress the WAK2cTAP-induced phenotype. A mpk6, but not a mpk3, null allele is able to suppress the effects of this dominant WAK2 mutation, thus distinguishing MPK3 and MPK6, whose activity previously was thought to be redundant. Pectin activation of gene expression is abated in a wak2-null, but is tempered by the WAK-dominant allele that induces elevated basal stress-related transcript levels. The results suggest a mechanism in which changes to the cell wall can lead to a large change in cellular responses and help to explain how pathogens and wounding can have general effects on growth. The Author 2011. Published by the Molecular Plant Shanghai Editorial Office in association with Oxford University Press on behalf of CSPB and IPPE, SIBS, CAS.2011 © The Author 2011. Published by the Molecular Plant Shanghai Editorial Office in association with Oxford University Press on behalf of CSPB and IPPE, SIBS, CAS.
Using metabolic oligosaccharide engineering to induce immune-mediated cell killing of bacterial pathogens Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2020-01-01
Creator: Brendan H. Pulsifer
Access: Access restricted to the Bowdoin Community
Pectin dependent cell adhesion restored by a mutant microtubule organizing membrane protein
Date: 2021-04-01
Creator: Bruce D. Kohorn, Jacob Dexter-Meldrum, Frances D.H. Zorensky, Salem Chabout, Gregory, Mouille, Susan Kohorn
Access: Open access
- The cellulose-and pectin-rich plant cell wall defines cell structure, mediates defense against pathogens, and facilitates plant cell adhesion. An adhesion mutant screen of Arabidopsis hypocotyls identified a new allele of QUASIMODO2 (QUA2), a gene required for pectin accumulation and whose mutants have reduced pectin content and adhesion defects. A suppressor of qua2 was also isolated and describes a null allele of SABRE (SAB), which encodes a previously described plasma membrane protein required for longitudinal cellular expansion that organizes the tubulin cytoskeleton. sab mutants have increased pectin content, increased levels of expression of pectin methylesterases and extensins, and reduced cell surface area relative to qua2 and Wild Type, con-tributing to a restoration of cell adhesion.
Microblogging Practices of Virtual Organizations: Commonalities and Contrasts
Date: 2013-04-12
Creator: Jing Wang
Access: Open access
- Microblogging is becoming increasingly pervasive in computer-supported collaboration, attracting various types of users. Organizations, as one type, are willing to leverage this social media service for their operation, but lack guidance of how to effectively manage their organizational microblogs. However, research on microblogging practices at organizational level, especially in virtual organizations, is very limited. To enhance the understanding of how virtual organizations use microblogs in similar and different ways, we investigate microblogging practices of two virtual organizations by examining the content characteristics of their Twitter posts. We identify eleven categories of microblog themes of three dimensions, consisting of both common and different categories between the two organizations. We further enumerate their potential impacts on organizational context, discuss differences between the two organizations, and compare these organizational practices with personal ones.
Climate change and health costs of air emissions from biofuels and gasoline
Date: 2009-02-10
Creator: Jason Hill, Stephen Polasky, Erik Nelson, David Tilman, Hong, Huo, Lindsay Ludwig, James Neumann, Haochi Zheng, Diego Bonta
Access: Open access
- Environmental impacts of energy use can impose large costs on society. We quantify and monetize the life-cycle climate-change and health effects of greenhouse gas (GHG) and fine particulate matter (PM2.5) emissions from gasoline, corn ethanol, and cellulosic ethanol. For each billion ethanol-equivalent gallons of fuel produced and combusted in the US, the combined climate-change and health costs are $469 million for gasoline, $472-952 million for corn ethanol depending on biorefinery heat source (natural gas, corn stover, or coal) and technology, but only $123-208 million for cellulosic ethanol depending on feedstock (prairie biomass, Miscanthus, corn stover, or switchgrass). Moreover, a geographically explicit life-cycle analysis that tracks PM2.5 emissions and exposure relative to U.S. population shows regional shifts in health costs dependent on fuel production systems. Because cellulosic ethanol can offer health benefits from PM2.5 reduction that are of comparable importance to its climate-change benefits from GHG reduction, a shift from gasoline to cellulosic ethanol has greater advantages than previously recognized. These advantages are critically dependent on the source of land used to produce biomass for biofuels, on the magnitude of any indirect land use that may result, and on other as yet unmeasured environmental impacts of biofuels. © 2009 by The National Academy of Sciences of the USA.
Solving which trilemma? The many interpretations of equality, Pareto, and freedom of occupational choice
Date: 2017-08-01
Creator: Kristi A. Olson
Access: Open access
- According to the trilemma claim, we cannot have all three of equality, Pareto, and freedom of occupational choice. In response to the trilemma, John Rawls famously sacrificed equality by introducing incentives. In contrast, GA Cohen and others argued that we can, in fact, have all three provided that individuals are properly motivated by an egalitarian ethos. The incentives debate, then, concerns the plausibility of the ethos solution versus the plausibility of the incentives solution. Considerable ink has been spilled on both sides of the debate. Yet, in this essay, I argue that we cannot have this debate until we clarify the terms. Once we clarify the terms, however, we might discover that there is no debate to be had. This is because, depending on how equality, Pareto, and freedom of occupational choice are interpreted, there might not be a trilemma in the first place. Specifically, I use a small but crucial distinction in how equality, the egalitarian ethos, and Pareto are assessed – what I call the internal/external distinction – to disentangle the various paths each solution – the ethos or incentives – could take. I conclude that both solutions have gained illicit plausibility by virtue of not keeping the distinction straight.