Showing 481 - 490 of 733 Items
Uneven Increases in Racial Diversity of US Geoscience Undergraduates
Date: 2021-06-15
Creator: Rachel J. Beane, Eric M.D. Baer, Rowan Lockwood, R. Heather Macdonald, John, R., McDaris, Vernon R. Morris, I. Joshua Villalobos, Lisa D. White
Access: Open access
Rapid oligo-galacturonide induced changes in protein phosphorylation in arabidopsis
Date: 2016-04-01
Creator: Bruce D. Kohorn, Divya Hoon, Benjamin B. Minkoff, Michael R. Sussman, Susan L., Kohorn
Access: Open access
- The wall-associated kinases (WAKs)1 are receptor protein kinases that bind to long polymers of cross-linked pectin in the cell wall. These plasma-membrane-associated protein kinases also bind soluble pectin fragments called oligo-galacturonides (OGs) released from the wall after pathogen attack and damage. WAKs are required for cell expansion during development but bind water soluble OGs generated from walls with a higher affinity than the wall-associated polysaccharides. OGs activate a WAKdependent, distinct stress-like response pathway to help plants resist pathogen attack. In this report, a quantitative mass-spectrometric-based phosphoproteomic analysis was used to identify Arabidopsis cellular events rapidly induced by OGs in planta. Using N14/ N15 isotopic in vivo metabolic labeling, we screened 1,000 phosphoproteins for rapid OG-induced changes and found 50 proteins with increased phosphorylation, while there were none that decreased significantly. Seven of the phosphosites within these proteins overlap with those altered by another signaling molecule plants use to indicate the presence of pathogens (the bacterial "elicitor" peptide Flg22), indicating distinct but overlapping pathways activated by these two types of chemicals. Genetic analysis of genes encoding 10 OG-specific and two Flg22/OG-induced phosphoproteins reveals that null mutations in eight proteins compromise the OG response. These phosphorylated proteins with genetic evidence supporting their role in the OG response include two cytoplasmic kinases, two membrane-associated scaffold proteins, a phospholipase C, a CDPK, an unknown cadmium response protein, and a motor protein. Null mutants in two proteins, the putative scaffold protein REM1.3, and a cytoplasmic receptor like kinase ROG2, enhance and suppress, respectively, a dominant WAK allele. Altogether, the results of these chemical and genetic experiments reveal the identity of several phosphorylated proteins involved in the kinase/ phosphatase-mediated signaling pathway initiated by cell wall changes.
The Rubble of Culture: Debris of an Extinct Thought
Date: 2023-01-01
Creator: David A. Collings
Access: Open access
- Humanity now faces the possibility that it will become extinct over the next few decades or so. This is not simply a reality about the biological fate of the species; it also raises the prospect of thought’s own extinction. But what does it mean for thought that it, too, might disappear? Thought’s possible disappearance shatters the assumption, at work across all the institutions and disciplines of the West, that one version or another of thought is enduring and will survive. As it turns out, no familiar practice rests on a secure ground; under the sign of the terminus - the prospect of humanity’s extinction - each one is shattered and undone. The cultural legacy becomes a field of rubble. In dozens of short essays, this book moves through this field. It takes up a host of specific inheritances and traces how each is shattered and transformed by an extinct thought. It engages with religion, philosophy, history, literature, ethics, studies of political power and resistance, and depictions of humanity’s place in the nonhuman world. It reconsiders the emergence of capitalism and of biopower, the science of climate change, the import of mediation and technology, and philosophies of temporality. Moreover, it contends with many innovative waves of thought over the past two centuries, from German idealism to deconstruction, from psychoanalysis to queer theory, from decolonizing theory to Afropessimism, and from the critique of ideology to speculative realism. It concludes by assessing what it is like for thought, having confronted its extinction, to live on in this debris, to dance with its own oblivion.
Virtual Communities Don’t Exist: Avoiding Digital Dualism in Studying Collaboration
Date: 2013-04-12
Creator: PJ Rey, Nathan Jurgenson
Access: Open access
- Effective collaboration in communities requires information sharing. Though digital media may have certain affordances that encourage us to communicate differently than in the past, the communities these media facilitate are no less real than communities bound together by voice or text. In this paper, we argue that idea of “virtual communities” is misleading. Communities and collaboration occur not in some virtual world or a new, cyber, space, but instead they are part of one reality influenced simultaneously by materiality and the various flows of information—digital included. In light of this argument, we implore researchers to take serious the influence of digitality, and, specific to this conference, those looking primarily at digitality to take seriously the materiality, bodies, history, and politics not separate from but deeply interpenetrating the digital. The changes in community organization brought about by digital media should not be thought of or called “virtual” (e.g., “virtual teams” as opposed to real ones), but instead part of one augmented community. Presented at the Collaborative Organizations & Social Media Conference at Bowdoin College on April 12, 2013.
Genetic_variation_in_the_serotonin_transporter_gene_influences_ERP
Date: 2015-11-01
Creator: Robert S. Ross, Paolo Medrano, Kaitlin Boyle, Andrew Smolen, Tim Curran, Erika Nyhus
Access: Open access
Alpha modulation in younger and older adults during distracted encoding
Date: 2022-06-01
Creator: Syanah C. Wynn, Erika Nyhus, Ole Jensen
Access: Open access
RoboGrams: A lightweight message passing architecture for RoboCup soccer
Date: 2015-01-01
Creator: Elizabeth Mamantov, William Silver, William Dawson, Eric Chown
Access: Open access
- RoboGrams is a lightweight and efficient message passing architecture that we designed for the RoboCup domain and that has been successfully used by the Northern Bites SPL team. This unique architecture provides a framework for separating code into strongly decoupled modules, which are combined into configurable dataflow graphs. We present several different architecture types and preexisting message passing implementations, but among all of these, we contend that Robo-Grams' features make it particularly well suited for use in RoboCup. As a success story, we describe the Northern Bites' use of RoboGrams and the benefits it has provided to a single team, but we also suggest that it could help SPL teams collaborate in the future.
Homolog Pairing at the Push of a Button
Date: 2019-11-04
Creator: Jack R. Bateman, Judith A. Kassis
Access: Open access
- Homologous chromosomes pair in somatic cells in Drosophila, but how this occurs is poorly understood. In this issue of Developmental Cell, Viets et al. (2019) show that proteins and chromatin structure mediate pairing and argue against a DNA sequence-based mechanism.
Risks of multimodal signaling: Bat predators attend to dynamic motion in frog sexual displays
Date: 2014-09-01
Creator: Wouter Halfwerk, Marjorie M. Dixon, Kristina J. Ottens, Ryan C. Taylor, Michael J., Ryan, Rachel A. Page, Patricia L. Jones
Access: Open access
- Many sexual displays contain multiple components that are received through a variety of sensory modalities. Primary and secondary signal components can interact to induce novel receiver responses and become targets of sexual selection as complex signals. However, predators can also use these complex signals for prey assessment, which may limit the evolution of elaborate sexual signals. We tested whether a multimodal sexual display of the male túngara frog (Physalaemus pustulosus) increases predation risk from the fringe-lipped bat (Trachops cirrhosus) when compared with a unimodal display. We gave bats a choice to attack one of two frog models: a model with a vocal sac moving in synchrony with a mating call (multisensory cue), or a control model with the call but no vocal sac movement (unimodal cue). Bats preferred to attack the model associated with the multimodal display. Furthermore, we determined that bats perceive the vocal sac using echolocation rather than visual cues. Our data illustrate the costs associated with multimodal signaling and that sexual and natural selection pressures on the same trait are not always mediated through the same sensory modalities. These data are important when considering the role of environmental fluctuations on signal evolution as different sensory modalities will be differentially affected.
Erratum: Context-dependent protein stabilization by methionine-to- leucine substitution shown in T4 lysozyme (Protein Science (November 3, 1998) 7:3 (772))
Date: 1998-01-01
Creator: L. A. Lipscomb, N. C. Gassner, S. D. Snow, A. M. Eldridge, W. A., Baase, D. L. Drew, B. W. Matthews
Access: Open access