Showing 201 - 250 of 733 Items

Date: 2018-01-01

Creator: Sree Padma

Access: Open access

Sri Lanka's 69-year-old parliamentary democracy continues with power concentrated at the center, and consequently, the country's non-Sinhala-Buddhist minorities on the periphery continue to press for equal rights, while ethnic strife hinders prospects for unified progress. Maithripala Sirisena, president since 2015, promises reconciliation but has received little cooperation from the majority Sinhala Buddhists.

Date: 2019-01-01

Creator: Sean Barker, Timothy Wood, Prashant Shenoy, Ramesh Sitaraman

Access: Open access

Content-based page sharing is a technique often used in virtualized environments to reduce server memory requirements. Many systems have been proposed to capture the benefits of page sharing. However, there have been few analyses of page sharing in general, both considering its real-world utility and typical sources of sharing potential. We provide insight into this issue through an exploration and analysis of memory traces captured from real user machines and controlled virtual machines. First, we observe that absolute sharing levels (excluding zero pages) generally remain under 15%, contrasting with prior work that has often reported savings of 30% or more. Second, we find that sharing within individual machines often accounts for nearly all (>90%) of the sharing potential within a set of machines, with inter-machine sharing contributing only a small amount. Moreover, even small differences between machines significantly reduce what little inter-machine sharing might otherwise be possible. Third, we find that OS features like address space layout randomization can further diminish sharing potential. These findings both temper expectations of real-world sharing gains and suggest that sharing efforts may be equally effective if employed within the operating system of a single machine, rather than exclusively targeting groups of virtual machines.

Date: 2014-01-01

Creator: Stephen Meardon

Access: Open access

Date: 2012-10-01

Creator: Therese Biedl, Mohammad T. Irfan, Justin Iwerks, Joondong Kim, Joseph S.B., Mitchell

Access: Open access

We explore the art gallery problem for the special case that the domain (gallery) P is an m-polyomino, a polyform whose cells are m unit squares. We study the combinatorics of guarding polyominoes in terms of the parameter m, in contrast with the traditional parameter n, the number of vertices of P. In particular, we show that ⌊m+1/3⌋ point guards are always sufficient and sometimes necessary to cover an m-polyomino, possibly with holes. When m < 3n/4-4, the sufficiency condition yields a strictly lower guard number than ⌊ n/4⌋, given by the art gallery theorem for orthogonal polygons. © 2012 Springer Science+Business Media, LLC.

Date: 2016-06-01

Creator: Collin S. Roesler

Access: Open access

Date: 2015-11-01

Creator: Robert S. Ross, Paolo Medrano, Kaitlin Boyle, Andrew Smolen, Tim Curran, Erika Nyhus

Access: Open access

Recognition memory is defined as the ability to recognize a previously encountered stimulus and has been associated with spatially and temporally distinct event-related potentials (ERPs). Allelic variations of the serotonin transporter gene (SLC6A4) have recently been shown to impact memory performance. Common variants of the serotonin transporter-linked polymorphic region (5HTTLPR) of the SLC6A4 gene result in long (l) and short (s) allelic variants with carriers of the s allele having lowered transcriptional efficiency. Thus, the current study examines the effects polymorphisms of the SLC6A4 gene have on performance and ERP amplitudes commonly associated with recognition memory. Electroencephalogram (EEG), genetic, and behavioral data were collected from sixty participants as they performed an item and source memory recognition task. In both tasks, participants studied and encoded 200 words, which were then mixed with 200 new words during retrieval. Participants were monitored with EEG during the retrieval portion of each memory task. EEG electrodes were grouped into four ROIs, left anterior superior, right anterior superior, left posterior superior, and right posterior superior. ERP mean amplitudes during hits in the item and source memory task were compared to correctly recognizing new items (correct rejections). Results show that s-carriers have decreased mean hit amplitudes in both the right anterior superior ROI 1000-1500. ms post stimulus during the source memory task and the left anterior superior ROI 300-500. ms post stimulus during the item memory task. These results suggest that individual differences due to genetic variation of the serotonin transporter gene influences recognition memory. © 2015 Elsevier Ltd.

Date: 2008-05-22

Creator: Eric Chown, Byron Boots

Access: Open access

In this chapter we will describe the central mechanisms that influence how people learn about large-scale space. We will focus particularly on how these mechanisms enable people to effectively cope with both the uncertainty inherent in a constantly changing world and also with the high information content of natural environments. The major lessons are that humans get by with a "less is more" approach to building structure, and that they are able to quickly adapt to environmental changes thanks to a range of general purpose mechanisms. By looking at abstract principles, instead of concrete implementation details, it is shown that the study of human learning can provide valuable lessons for robotics. Finally, these issues are discussed in the context of an implementation on a mobile robot. © 2007 Springer-Verlag Berlin Heidelberg.

Date: 2010-12-01

Creator: Michael M. Franz

Access: Open access

In January 2010, the Supreme Court in Citizens United v. FEC overturned long-standing regulations governing the role of unions and corporations in sponsoring pro-candidate advocacy. Many predicted a deleterious effect on the electoral process. In the aftermath of the midterm elections, a number of questions deserve consideration. Was the observed level of outside spending abnormally high in 2010? What can we say about the potential effect of outside spending on the outcomes of House and Senate races? Moreover, what has the decision done to the power of parties and, most especially, their ability to compete with special interests in backing federal candidates? This paper investigates these questions using data from the Wesleyan Media Project, which tracked political ads in 2010. The initial evidence suggests that while interest groups were aggressive players in the air war, their impact may not have been as negative or as large as initially predicted. © 2011 Berkeley Electronic Press.

Date: 2012-09-01

Creator: Yao Tang, Ke Pang

Access: Open access

We compare the welfare of different combinations of monetary and currency policies in an open-economy macroeconomic model that incorporates two important features of many small economies: a high level of vertical international trade and a prevalent use of a large trade partner's currency as the invoicing currency for both imports and exports. In this environment, a small economy prefers a fixed exchange rate regime over a flexible regime, while the larger economy prefers a flexible exchange rate regime. There are two main causes underlying our results. First, in the presence of sticky prices, relative prices adjust through changes in the exchange rate. Multiple stages of production and trade make it more difficult for one exchange rate to balance the whole economy by adjusting several relative prices throughout the vertical chain of production and trade. Namely, there is a trade-off between delivering an efficient relative price between home and foreign final goods and delivering an efficient relative price between home and foreign intermediate goods. Second, because the small economy uses the larger economy's currency in trade, it faces a high degree of exchange rate pass-through under a flexible regime and hence suffers from the lack of efficient relative prices in vertical trade. The larger economy, however, does not face this problem because its level of exchange rate pass-through is low.

Date: 2024-02-20

Creator: Stephen Meardon

Access: Open access

Henry C. Carey led a school of post-Civil War U.S. currency doctors prescribing an “elastic currency,” expanding and contracting according to commercial needs. The problem for the Careyites was reconciling elasticity, which implied inconvertibility with gold, with the related aim of decentralized financial power. Careyite currency doctors included, among others, Wallace P. Groom, editor of the New York Mercantile Journal, and Henry Carey Baird, Carey’s own nephew and inheritor of his mantle. Their prescribed reform of the banking system featured a financial innovation that would remove superfluous currency from circulation while supplying what was needed. The innovation was an “interconvertible bond,” a debt instrument of the U.S. Treasury that was to be issued upon demand and redeemable for currency at the option of the holder. Its function was supposed to be like the mechanical governor of a steam engine, operating by a “subtle principle” that obviated human governing power and discretion. The Carey school’s prescription and its rationale remained salient up to the advent of the Federal Reserve System.

Date: 2015-04-01

Creator: Jeffrey C. Yu, Zachary D. Fox, James L. Crimp, Hana E. Littleford, Andrea L., Jowdry, William R. Jackman

Access: Open access

Intercellular communication by the hedgehog cell signaling pathway is necessary for tooth development throughout the vertebrates, but it remains unclear which specific developmental signals control cell behavior at different stages of odontogenesis. To address this issue, we have manipulated hedgehog activity during zebrafish tooth development and visualized the results using confocal microscopy. Results: We first established that reporter lines for dlx2b, fli1, NF-κB, and prdm1a are markers for specific subsets of tooth germ tissues. We then blocked hedgehog signaling with cyclopamine and observed a reduction or elimination of the cranial neural crest derived dental papilla, which normally contains the cells that later give rise to dentin-producing odontoblasts. Upon further investigation, we observed that the dental papilla begins to form and then regresses in the absence of hedgehog signaling, through a mechanism unrelated to cell proliferation or apoptosis. We also found evidence of an isometric reduction in tooth size that correlates with the time of earliest hedgehog inhibition. Conclusions: We hypothesize that these results reveal a previously uncharacterized function of hedgehog signaling during tooth morphogenesis, regulating the number of cells in the dental papilla and thereby controlling tooth size.

Date: 1998-05-07

Creator: Michael F. Palopoli, Nipam H. Patel

Access: Open access

Segmental identifies along the insect body depend on the activities of Hox genes [1,2]. In Drosophila melanogaster, one well-studied Hox regulatory target is Distal-less (DII), which Is required for the development of distel limb structures [3]. In abdominal segments, DII transcription is prevented when Hox proteins of the Bithorax Complex (BX-C) bind to cis-regulatory elements upstream of the DII transcription start site [4,5]. Previous evolutionary comparisons of gene expression patterns suggest that this direct repression is conserved between Diptera and Lepidoptera, but is absent in the Crustacea [6,7]. We examined gene expression patterns in three orders of hexapods, all of which develop abdominal appendages, in order to determine when the strong repressive interaction between BX-C proteins and DII appeared during evolution. In each of the species examined, DII expression was initiated in abdominal cells despite the presence of high levels of BX-C proteins. It appears that the strong repressive effects of BX-C proteins on DII expression arose relatively late in insect evolution. We suggest that the regulatory interaction between the BX-C genes and DII has evolved within the hexapods in a complex, segment-specific manner.

Date: 1990-01-01

Creator: Paul Franco

Access: Open access

Date: 2001-01-01

Creator: A.B. Levy

Access: Open access

Date: 2012-12-01

Creator: Michael M. Franz

Access: Open access

This paper compares the levels of ad spending from outside groups and traditional party organizations across seven federal election cycles. The data show clearly that outside groups advertised at historic levels in 2012. Such intense efforts send two important signals to students of American campaign finance. The first involves a crisis in the system of limited donations to candidates and party committees moving forward. The second resurrects an old debate in political science about whether parties or candidates should be the center of our electoral process. The paper concludes with a consideration of possible reforms that might help restore parties and candidates to the center of issue debates in competitive federal elections.

Date: 2011-04-20

Creator: Zicheng Yu, D. W. Beilman, S. Frolking, G. M. MacDonald, N. T., Roulet, P. Camill, D. J. Charman

Access: Open access

Global peatlands store a very large carbon (C) pool located within a few meters of the atmosphere. Thus, peatland-atmosphere C exchange should be a major concern to global change scientists: Will large amounts of respired belowground C be released in a warmer climate, causing the climate to further warm (a positive climate feedback)? Will more C be sequestered due to increased plant growth in a warmer climate? How will land use change, fires, and permafrost thaw affect the magnitude and direction of carbon dioxide (CO ) and methane (CH ) exchange with the atmosphere? These questions remain challenging, but some significant progress has been made recently. 2 4

Date: 2008-05-01

Creator: Anna Selmecki, Maryam Gerami-Nejad, Carsten Paulson, Anja Forche, Judith, Berman

Access: Open access

Acquired azole resistance is a serious clinical problem that is often associated with the appearance of aneuploidy and, in particular, with the formation of an isochromosome [i(5L)] in the fungal opportunist Candida albicans. Here we exploited a series of isolates from an individual patient during the rapid acquisition of fluconazole resistance (FluR). Comparative genome hybridization arrays revealed that the presence of two extra copies of Chr5L, on the isochromosome, conferred increased FluR and that partial truncation of Chr5L reduced FluR. In vitro analysis of the strains by telomere-mediated truncations and by gene deletion assessed the contribution of all Chr5L genes and of four specific genes. Importantly, ERG11 (encoding the drug target) and a hyperactive allele of TAC1 (encoding a transcriptional regulator of drug efflux pumps) made independent, additive contributions to FluR in a gene copy number-dependent manner that was not different from the contributions of the entire Chr5L arm. Thus, the major mechanism by which i(5L) formation causes increased azole resistance is by amplifying two genes: ERG11 and TAC1. © 2008 The Authors.

Date: 2015-05-01

Creator: Daniel F. Stone

Access: Open access

Opportunity cost is widely considered to be a fundamental concept in economics. But the definition of the term continues to be both unclear and controversial. I describe how the term is widely used in two distinct ways, both in academic and non-academic contexts. I propose a practical way for educators to clarify the concept and related terminology.

Date: 2013-07-01

Creator: E. A.G. Schuur, B. W. Abbott, W. B. Bowden, V. Brovkin, P., Camill, J. G. Canadell, J. P. Chanton, F. S. Chapin, T. R. Christensen, P. Ciais, B. T. Crosby, C. I. Czimczik, G. Grosse, J. Harden, D. J. Hayes, G. Hugelius

Access: Open access

Approximately 1700 Pg of soil carbon (C) are stored in the northern circumpolar permafrost zone, more than twice as much C than in the atmosphere. The overall amount, rate, and form of C released to the atmosphere in a warmer world will influence the strength of the permafrost C feedback to climate change. We used a survey to quantify variability in the perception of the vulnerability of permafrost C to climate change. Experts were asked to provide quantitative estimates of permafrost change in response to four scenarios of warming. For the highest warming scenario (RCP 8.5), experts hypothesized that C release from permafrost zone soils could be 19-45 Pg C by 2040, 162-288 Pg C by 2100, and 381-616 Pg C by 2300 in CO equivalent using 100-year CH global warming potential (GWP). These values become 50 % larger using 20-year CH GWP, with a third to a half of expected climate forcing coming from CH even though CH was only 2.3 % of the expected C release. Experts projected that two-thirds of this release could be avoided under the lowest warming scenario (RCP 2.6). These results highlight the potential risk from permafrost thaw and serve to frame a hypothesis about the magnitude of this feedback to climate change. However, the level of emissions proposed here are unlikely to overshadow the impact of fossil fuel burning, which will continue to be the main source of C emissions and climate forcing. © 2013 The Author(s). 2 4 4 4 4

Date: 2017-11-22

Creator: Emanuele Organelli, Marie Barbieux, Hervé Claustre, Catherine Schmechtig, Antoine, Poteau, Annick Bricaud, Emmanuel Boss, Nathan Briggs, Giorgio Dall'Olmo, Fabrizio D'Ortenzio, Edouard Leymarie, Antoine Mangin, Grigor Obolensky, Christophe Penkerc'H, Louis Prieur, Collin Roesler, Romain Serra, Julia Uitz, Xiaogang Xing

Access: Open access

Since 2012, an array of 105 Biogeochemical-Argo (BGC-Argo) floats has been deployed across the world's oceans to assist in filling observational gaps that are required for characterizing open-ocean environments. Profiles of biogeochemical (chlorophyll and dissolved organic matter) and optical (single-wavelength particulate optical backscattering, downward irradiance at three wavelengths, and photosynthetically available radiation) variables are collected in the upper 1000 m every 1 to 10 days. The database of 9837 vertical profiles collected up to January 2016 is presented and its spatial and temporal coverage is discussed. Each variable is quality controlled with specifically developed procedures and its time series is quality-assessed to identify issues related to biofouling and/or instrument drift. A second database of 5748 profile-derived products within the first optical depth (i.e., the layer of interest for satellite remote sensing) is also presented and its spatiotemporal distribution discussed. This database, devoted to field and remote ocean color applications, includes diffuse attenuation coefficients for downward irradiance at three narrow wavebands and one broad waveband (photosynthetically available radiation), calibrated chlorophyll and fluorescent dissolved organic matter concentrations, and single-wavelength particulate optical backscattering. To demonstrate the applicability of these databases, data within the first optical depth are compared with previously established bio-optical models and used to validate remotely derived bio-optical products. The quality-controlled databases are publicly available from the SEANOE (SEA scieNtific Open data Edition) publisher at https://doi.org/10.17882/49388 and https://doi.org/10.17882/47142 for vertical profiles and products within the first optical depth, respectively.

Date: 2004-01-01

Creator: Michael Butler, Amy S. Johnson

Access: Open access

Melanin has been associated with increased resistance to abrasion, decreased wear and lowered barb breakage in feathers. But, this association was inferred without considering barb position along the rachis as a potentially confounding variable. We examined the cross-sectional area, breaking force, breaking stress, breaking strain and toughness of melanized and unmelanized barbs along the entire rachis of a primary feather from an osprey (Pandion haliaetus). Although breaking force was higher for melanized barbs, breaking stress (force divided by cross-sectional area) was greater for unmelanized barbs. But when position was considered, all mechanical differences between melanized and unmelanized barbs disappeared. Barb breaking stress, breaking strain and toughness decreased, and breaking stiffness increased, distally along the rachis. These proximal-distal material property changes are small and seem unlikely to affect flight performance of barbs. Our observations of barb bending, breaking and morphology, however, lead us to propose a design principle for barbs. We propose that, by being thicker-walled dorso-ventrally, the barb's flexural stiffness is increased during flight; but, by allowing for twisting when loaded with dangerously high forces, barbs firstly avoid failure by bending and secondly avoid complete failure by buckling rather than rupturing.

Date: 2008-06-01

Creator: Stephen Polasky, Erik Nelson, Jeff Camm, Blair Csuti, Paul, Fackler, Eric Lonsdorf, Claire Montgomery, Denis White, Jeff Arthur

Access: Open access

Expanding human population and economic growth have led to large-scale conversion of natural habitat to human-dominated landscapes with consequent large-scale declines in biodiversity. Conserving biodiversity, while at the same time meeting expanding human needs, is an issue of utmost importance. In this paper we develop a spatially explicit landscape-level model for analyzing the biological and economic consequences of alternative land-use patterns. The spatially explicit biological model incorporates habitat preferences, area requirements and dispersal ability between habitat patches for terrestrial vertebrate species to predict the likely number of species that will be sustained on the landscape. The spatially explicit economic model incorporates site characteristics and location to predict economic returns for a variety of potential land uses. We apply the model to search for efficient land-use patterns that maximize biodiversity conservation objectives for given levels of economic returns, and vice versa. We apply the model to the Willamette Basin, Oregon, USA. By thinking carefully about the arrangement of activities, we find land-use patterns that sustain high levels of biodiversity and economic returns. Compared to the 1990 land-use pattern, we show that both biodiversity conservation and the value of economic activity could be increased substantially. © 2008 Elsevier Ltd.

Date: 2017-09-06

Creator: C. Chong, Mason A. Porter, P. G. Kevrekidis, C. Daraio

Access: Open access

The study of granular crystals, which are nonlinear metamaterials that consist of closely packed arrays of particles that interact elastically, is a vibrant area of research that combines ideas from disciplines such as materials science, nonlinear dynamics, and condensed-matter physics. Granular crystals exploit geometrical nonlinearities in their constitutive microstructure to produce properties (such as tunability and energy localization) that are not conventional to engineering materials and linear devices. In this topical review, we focus on recent experimental, computational, and theoretical results on nonlinear coherent structures in granular crystals. Such structures - which include traveling solitary waves, dispersive shock waves, and discrete breathers - have fascinating dynamics, including a diversity of both transient features and robust, long-lived patterns that emerge from broad classes of initial data. In our review, we primarily discuss phenomena in one-dimensional crystals, as most research to date has focused on such scenarios, but we also present some extensions to two-dimensional settings. Throughout the review, we highlight open problems and discuss a variety of potential engineering applications that arise from the rich dynamic response of granular crystals.

Date: 2013-04-12

Creator: Steven Jones

Access: Open access

The real estate industry, like many, is one based on a competitive consumer culture in which professionals vie for the business and, ultimately, the loyalty of customers. In this case, those customers are purchasing what, for most, is a significant investment, requiring them to navigate various legal and regulatory processes that might be impossible without the assistance of a knowledgeable, seasoned agent. It is the presence of agency that renders real estate unique from retail and other industries where goods and services trade hands. Furthermore, the rise of various information and communication technologies (ICT) over the course of the past 25 years may have led to new challenges for real estate agents and allied professionals. Some scholars surmise that the increased prevalence of ICTs in various industries can become disruptive to those industries, causing individuals and organizations working within them to either adapt accordingly or become obsolete (Bower and Christensen 1995; Markus, et al. 2006).

Date: 2013-05-07

Creator: Yao Tang, Haifang Huang

Access: Open access

We estimate the effects of real exchange rate movements on employment in US cities between 2003 and 2010. We explore the differences in the composition of local industries to construct city-specific changes in exchange rates and estimate their effects on local employment in manufacturing industries and in nonmanufacturing industries. Controlling for year and city fixed effects, we find that a depreciation of the US dollar increased local employment in the manufacturing industries, our proxy for the tradable sector. The depreciation also increased employment in the nonmanufacturing industries, the nontradable sector. Furthermore, the effects on nonmanufacturing employment were stronger in cities that had a higher fraction of manufacturing employment, indicating the exchange rate movements’ indirect effects through the manufacturing industries. We also consider an alternative definition of the tradable sector that is broadened to include five service industries. The findings are similar.

Date: 2013-04-12

Creator: Alex Primo

Access: Open access

This article discusses how interactions in organizational blogs participate in the emergence of the organization itself. Based on the principles of The Montreal School of organizational communication, the paper reflects on how the recursive relationship between texts and conversations in blogs, according to their affordances, mobilizes the organization and contributes to its continuing creation. In order to conduct this argument, the concept of social media, uses of organizational blogs and the main contributions of The Montreal School are analyzed. Finally, this article demonstrates how blogs contribute to the definition of the organization. Beyond their promotional potential, the blog’ role as co-creator of the organization is highlighted.

Date: 2019-11-01

Creator: Alberto Bellido, Toni Ciudad, Belén Hermosa, Encarnación Andaluz, Anja, Forche, Germán Larriba

Access: Open access

Candida albicans, the most common fungal pathogen, is a diploid with a genome that is rich in repeats and has high levels of heterozygosity. To study the role of different recombination pathways on direct-repeat recombination, we replaced either allele of the RAD52 gene (Chr6) with the URA-blaster cassette (hisG-URA3-hisG), measured rates of URA3 loss as resistance to 5-fluoroorotic acid (5FOAR) and used CHEF Southern hybridization and SNP-RFLP analysis to identify recombination mechanisms and their frequency in wildtype and recombination mutants. FOAR rates varied little across different strain backgrounds. In contrast, the type and frequency of mechanisms underlying direct repeat recombination varied greatly. For example, wildtype, rad59 and lig4 strains all displayed a bias for URA3 loss via pop-out/deletion vs. inter-homolog recombination and this bias was reduced in rad51 mutants. In addition, in rad51-derived 5FOAR strains direct repeat recombination was associated with ectopic translocation (5%), chromosome loss/truncation (14%) and inter-homolog recombination (6%). In the absence of RAD52, URA3 loss was mostly due to chromosome loss and truncation (80–90%), and the bias of retained allele frequency points to the presence of a recessive lethal allele on Chr6B. However, a few single-strand annealing (SSA)-like events were identified and these were independent of either Rad59 or Lig4. Finally, the specific sizes of Chr6 truncations suggest that the inserted URA-blaster could represent a fragile site.

Date: 2016-12-16

Creator: Emily L. Clark, Madhu Emmadi, Katharine L. Krupp, Ananda R. Podilapu, Jennifer D., Helble, Suvarn S. Kulkarni, Danielle H. Dube

Access: Open access

Bacterial glycans contain rare, exclusively bacterial monosaccharides that are frequently linked to pathogenesis and essentially absent from human cells. Therefore, bacterial glycans are intriguing molecular targets. However, systematic discovery of bacterial glycoproteins is hampered by the presence of rare deoxy amino sugars, which are refractory to traditional glycan-binding reagents. Thus, the development of chemical tools that label bacterial glycans is a crucial step toward discovering and targeting these biomolecules. Here, we explore the extent to which metabolic glycan labeling facilitates the studying and targeting of glycoproteins in a range of pathogenic and symbiotic bacterial strains. We began with an azide-containing analog of the naturally abundant monosaccharide N-acetylglucosamine and discovered that it is not broadly incorporated into bacterial glycans, thus revealing a need for additional azidosugar substrates to broaden the utility of metabolic glycan labeling in bacteria. Therefore, we designed and synthesized analogs of the rare deoxy amino d-sugars N-acetylfucosamine, bacillosamine, and 2,4-diacetamido-2,4,6-trideoxygalactose and established that these analogs are differentially incorporated into glycan-containing structures in a range of pathogenic and symbiotic bacterial species. Further application of these analogs will refine our knowledge of the glycan repertoire in diverse bacteria and may find utility in treating a variety of infectious diseases with selectivity.

Date: 2016-05-05

Creator: C. Chong, E. Kim, E. G. Charalampidis, H. Kim, F., Li, P. G. Kevrekidis

Access: Open access

This article explores the excitation of different vibrational states in a spatially extended dynamical system through theory and experiment. As a prototypical example, we consider a one-dimensional packing of spherical particles (a so-called granular chain) that is subject to harmonic boundary excitation. The combination of the multimodal nature of the system and the strong coupling between the particles due to the nonlinear Hertzian contact force leads to broad regions in frequency where different vibrational states are possible. In certain parametric regions, we demonstrate that the nonlinear Schrödinger equation predicts the corresponding modes fairly well. The electromechanical model we apply predicts accurately the conversion from the obtained mechanical energy to the electrical energy observed in experiments.

Date: 2016-06-13

Creator: Neel Nadkarni, Andres F. Arrieta, Christopher Chong, Dennis M. Kochmann, Chiara, Daraio

Access: Open access

We present a model system for strongly nonlinear transition waves generated in a periodic lattice of bistable members connected by magnetic links. The asymmetry of the on-site energy wells created by the bistable members produces a mechanical diode that supports only unidirectional transition wave propagation with constant wave velocity. We theoretically justify the cause of the unidirectionality of the transition wave and confirm these predictions by experiments and simulations. We further identify how the wave velocity and profile are uniquely linked to the double-well energy landscape, which serves as a blueprint for transition wave control.

Date: 2019-11-10

Creator: Paolo Di Vecchia, Andrés Luna, Stephen G. Naculich, Rodolfo Russo, Gabriele, Veneziano, Chris D. White

Access: Open access

The structure of scattering amplitudes in supergravity theories continues to be of interest. Recently, the amplitude for 2→2 scattering in N=8 supergravity was presented at three-loop order for the first time. The result can be written in terms of an exponentiated one-loop contribution, modulo a remainder function which is free of infrared singularities, but contains leading terms in the high energy Regge limit. We explain the origin of these terms from a well-known, unitarity-restoring exponentiation of the high-energy gravitational S-matrix in impact-parameter space. Furthermore, we predict the existence of similar terms in the remainder function at all higher loop orders. Our results provide a non-trivial cross-check of the recent three-loop calculation, and a necessary consistency constraint for any future calculation at higher loops.

Date: 2016-10-01

Creator: Thomas G. Huntington, William M. Balch, George R. Aiken, Justin Sheffield, Lifeng, Luo, Collin S. Roesler, Philip Camill

Access: Open access

Ongoing climate change is affecting the concentration, export (flux), and timing of dissolved organic carbon (DOC) exported to the Gulf of Maine (GoM) through changes in hydrologic regime. DOC export was calculated for water years 1950 through 2013 for 20 rivers and for water years 1930 through 2013 for 14 rivers draining to the GoM. DOC export was also estimated for the 21st century based on climate and hydrologic modeling in a previously published study. DOC export was calculated by using the regression model LOADEST to fit seasonally adjusted concentration discharge (C-Q) relations. Our results are an analysis of the sensitivity of DOC export to changes in hydrologic conditions over time since land cover and vegetation were held constant over time. Despite large interannual variability, all rivers had increasing DOC export during winter and these trends were significant (p < 0.05) in 10 out of 20 rivers for 1950 to 2013 and in 13 out of 14 rivers for 1930 to 2013. All rivers also had increasing annual export of DOC although fewer trends were statistically significant than for winter export. Projections for DOC export during the 21st century were variable depending on the climate model and greenhouse gas emission scenario that affected future river discharge through effects on precipitation and evapotranspiration. The most consistent result was a significant increase in DOC export in winter in all model-by-emission scenarios. DOC export was projected to decrease during the summer in all model-by-emission scenarios, with statistically significant decreases in half of the scenarios.

Date: 2006-04-01

Creator: Alix Coste, Vincent Turner, Françoise Ischer, Joachim Morschhäuser, Anja, Forche, Anna Selmecki, Judith Berman, Jacques Bille, Dominique Sanglard

Access: Open access

TAC1, a Candida albicans transcription factor situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole resistance. We showed previously the existence of both wild-type and hyperactive TAC1 alleles. Wild-type alleles mediate upregulation of CDR1 and CDR2 upon exposure to inducers such as fluphenazine, while hyperactive alleles result in constitutive high expression of CDR1 and CDR2. Here we recovered TAC1 alleles from two pairs of matched azole-susceptible (DSY294; FH1: heterozygous at mating-type locus) and azole-resistant isolates (DSY296; FH3: homozygous at mating-type locus). Two different TAC1 wild-type alleles were recovered from DSY294 (TAC1-3 and TAC1-4) while a single hyperactive allele (TAC1-5) was isolated from DSY296. A single amino acid (aa) difference between TAC1-4 and TAC1-5 (Asn977 to Asp or N977D) was observed in a region corresponding to the predicted activation domain of Tac1p. Two TAC1 alleles were recovered from FH1 (TAC1-6 and TAC1-7) and a single hyperactive allele (TAC1-7) was recovered from FH3. The N977D change was seen in TAC1-7 in addition to several other aa differences. The importance of N977D in conferring hyperactivity to TAC1 was confirmed by site-directed mutagenesis. Both hyperactive alleles TAC1-5 and TAC1-7 were codominant with wild-type alleles and conferred hyperactive phenotypes only when homozygous. The mechanisms by which hyperactive alleles become homozygous was addressed by comparative genome hybridization and single nucleotide polymorphism arrays and indicated that loss of TAC1 heterozygosity can occur by recombination between portions of chromosome 5 or by chromosome 5 duplication. Copyright © 2006 by the Genetics Society of America.

Date: 2020-02-11

Creator: Elizabeth A. Hoge, Hannah E. Reese, Isabelle A. Oliva, Caroline D. Gabriel, Brittany M., Guidos, Eric Bui, Naomi M. Simon, Mary Ann Dutton

Access: Open access

Although mindfulness-based interventions (MBIs) have garnered empirical support for a wide range of psychological conditions, the psychological processes that mediate the relationship between MBIs and subsequent symptomatic improvement are less well-understood. In the present study we sought to examine, for the first time, the relationship between mindfulness, negative interpretation bias as measured by the homophone task, and anxiety among adults with Generalized Anxiety Disorder (GAD). Forty-two individuals with GAD completed measures of mindfulness, interpretation bias, and anxiety before and after treatment with Mindfulness-based Stress Reduction (MBSR). Contrary to prior research, we did not find evidence of an indirect relationship between baseline levels of mindfulness and anxiety via negative interpretation bias. MBSR did result in significant reductions in negative interpretation bias from baseline to post-treatment; however, we did not find evidence of an indirect relationship between changes in mindfulness and changes in anxiety via changes in interpretation bias. Taken together, these results provide minimal support for the hypothesized relationship between mindfulness, negative interpretation bias, and anxiety among adults with GAD. Limitations and specific suggestions for further inquiry are discussed.

Date: 2005-01-01

Creator: Anja Forche, Georgiana May, P. T. Magee

Access: Open access

Candida albicans is a diploid yeast with a predominantly clonal mode of reproduction, and no complete sexual cycle is known. As a commensal organism, it inhabits a variety of niches in humans. It becomes an opportunistic pathogen in immunocompromised patients and can cause both superficial and disseminated infections. It has been demonstrated that genome rearrangement and genetic variation in isolates of C. albicans are quite common. One possible mechanism for generating genome-level variation among individuals of this primarily clonal fungus is mutation and mitotic recombination leading to loss of heterozygosity (LOH). Taking advantage of a recently published genome-wide single-nucleotide polymorphism (SNP) map (A. Forche, P. T. Magee, B. B. Magee, and G. May, Eukaryot. Cell 3:705-714, 2004), an SNP microarray was developed for 23 SNP loci residing on chromosomes 5, 6, and 7. It was used to examine 21 strains previously shown to have undergone mitotic recombination at the GAL1 locus on chromosome 1 during infection in mice. In addition, karyotypes and morphological properties of these strains were evaluated. Our results show that during in vivo passaging, LOH events occur at observable frequencies, that such mitotic recombination events occur independently in different loci across the genome, and that changes in karyotypes and alterations of phenotypic characteristics can be observed alone, in combination, or together with LOH.

Date: 2010-06-01

Creator: Erika Nyhus, Tim Curran

Access: Open access

The primary aim of this review is to examine evidence for a functional role of gamma and theta oscillations in human episodic memory. It is proposed here that gamma and theta oscillations allow for the transient interaction between cortical structures and the hippocampus for the encoding and retrieval of episodic memories as described by the hippocampal memory indexing theory (Teyler and DiScenna, 1986). Gamma rhythms can act in the cortex to bind perceptual features and in the hippocampus to bind the rich perceptual and contextual information from diverse brain regions into episodic representations. Theta oscillations act to temporally order these individual episodic memory representations. Through feedback projections from the hippocampus to the cortex these gamma and theta patterns could cause the reinstatement of the entire episodic memory representation in the cortex. In addition, theta oscillations could allow for top-down control from the frontal cortex to the hippocampus modulating the encoding and retrieval of episodic memories. © 2009.

Date: 2000-05-01

Creator: Michael M. Franz

Access: Open access

Interest groups now play a prominent role in the air war. Their collective investment in election campaigns has skyrocketed in the aftermath of Citizens United. Yet questions remain about whether interest group advertising affects the content of the specific issues being discussed. Do groups enter campaigns and engage voters on the same issues as their candidate allies? Or does the presence of more advertisers introduce competitive issue streams? This paper examines ad buys in Senate elections between 2008 and 2014 and the presidential elections of 2008 and 2012. A primary goal of the paper is to uncover the effect of high and low levels of "issue convergence" on election outcomes. Strategists often express concern that too many voices on behalf of a candidate can weaken the impact of ads. One might expect that as convergence between a candidate and his or her allies goes up (meaning the issue content of the ad buys overlaps across advertisers), the impact of ads on votes will increase. Ad effects should be weaker when a candidate's ads discuss different issues from allied groups and party committees. The results, however, suggest that high rates of issue convergence are only weakly related to election outcomes (and not always in consistent ways).

Date: 2021-01-01

Creator: Emily M. Peterman, Michael J. Jercinovic, Rachel J. Beane, Cameron B. de Wet

Access: Open access

Cathodoluminescence (CL) images of kyanite reveal several internal textures, including sector zoning, oscillatory zoning, and cross-cutting relationships among different domains. Many textures observed in kyanite correspond to discrete events, thereby connecting kyanite textures to the pressure–temperature (P–T) history of the rock. To evaluate the record of metamorphism preserved by kyanite, metapelites were selected from three different orogens that reflect P–T conditions ranging from amphibolite to ultrahigh-pressure (UHP) facies. Cross-correlation of variations in CL intensity, chemistry, and crystal orientation within kyanite indicate the following findings. First, the preservation of original growth zones in kyanite from poly-metamorphic rocks demonstrates that growth zoning in kyanite persists through metamorphic events and is not erased by diffusion or complete recrystallization. In some samples, kyanite retains evidence of its reaction history during growth. Second, measured changes in absolute crystallographic orientation do not correspond with changes in CL intensity in any of the measured samples, including kyanite twins. Third, both kink banding and undulatory extinction are present across all samples, consistent with rotation about in the (100)[001] slip system. Kyanite from (U)HP samples exhibits higher amplitude undulations than kyanite from lower-grade lithologies, suggesting that crystallographic orientation data may provide complementary insight about deformation along the P–T path. Fourth, specific CL and trace element signatures in kyanite can be correlated with discrete metamorphic histories; yet, CL intensity and colour are affected by multiple elements, not a single controlling element. In sum, multiple generations of kyanite can be identified by careful cross-correlation of CL and geochemical data, and when combined with crystal orientation data, kyanite provides a robust record of a rock's P–T evolution.

Date: 2018-07-01

Creator: Danielle H. Dube

Access: Open access

“Drug Discovery” is a 13-week lecture and laboratory-based course that was developed to introduce non-science majors to foundational chemistry and biochemistry concepts as they relate to the unifying theme of drug discovery. The first part of this course strives to build students' understanding of molecules, their properties, the differences that enable them to be separated from one another, and their abilities to bind to biological receptors and elicit physiological effects. After building students' molecular worldview, the course then focuses on four classes of drugs: antimicrobials, drugs that affect the mind, steroid-based drugs, and anti-cancer drugs. During each of these modules, an emphasis is placed on how understanding the basis of disease and molecular-level interactions empowers us to identify novel medicinal compounds. Periodic in class discussions based on articles pertinent to class topics ranging from the spread of antibiotic resistance, to the molecular basis of addiction, to rational drug design, are held to enable students to relate course material to pressing problems of national and daily concern. In addition to class time, weekly inquiry-based laboratories allow students to critically analyze data related to course concepts, and later in the semester give students an opportunity to design and implement their own experiments to screen for antimicrobial activity. This course provides students with an understanding of the importance of chemistry and biochemistry to human health while emphasizing the process, strategies, and challenges related to drug discovery. © 2018 by The International Union of Biochemistry and Molecular Biology, 46:327–335, 2018.

Date: 2016-04-15

Creator: Michèle LaVigne, Andréa G. Grottoli, James E. Palardy, Robert M. Sherrell

Access: Open access

The coral skeleton barium to calcium ratio (Ba/Ca ), a proxy for seawater barium concentrations (Ba ), has been interpreted as a tracer of upwelling based on the characteristic "nutrient like" depth profile of Ba . However, in some tropical regions, such as the Gulf of Panamá, substantial influence of terrestrial runoff inputs and differences between the vertical distribution of Ba and that of the major nutrients (nitrate and phosphate) in the upper water column can complicate the interpretation of Ba/Ca as an upwelled nutrient proxy. In the Gulf of Panamá, contemporaneous Ba/Ca records from multiple colonies of Porites lobata, Pavona gigantea, and Pavona clavus corals record a nearly twofold change in surface water Ba as a 20-70% increase in skeletal Ba/Ca with excellent correlation among Ba/Ca records from co-located colonies (r = 0.86-0.99). These results provide, for the first time, an absolute calibration of the coral Ba proxy with a contemporaneous Ba record. Compiling the Ba/Ca records from three co-located colonies of each species into taxon-specific composite regressions reveals strong statistically significant correlations with the Ba time-series record (p < 0.001). Differences among taxa in regression slope, y-intercept, and average distribution coefficient, as well as a demonstration of the application of the P. clavus calibration to a previously published Ba/Ca record, emphasize the necessity of using taxon-specific calibrations to reconstruct changes in Ba with accuracy. These results support the application of Ba/Ca to reconstruct past changes in absolute Ba concentrations, adding an important tool to the collection of geochemical proxies for reconstructing surface ocean biogeochemical processes in the past. coral SW SW SW coral coral SW SW coral SW coral SW coral SW

Date: 2021-12-01

Creator: Lea Takács, Samuel P. Putnam, Catherine Monk, Hannah G. Dahlen, Charlene, Thornton, František Bartoš, Anastasia Topalidou, Lilian L. Peters

Access: Open access

The aim of this prospective longitudinal study was to examine the association between Cesarean section (CS) and child development and behavior. The sample consisted of 256 children who were born at term without serious perinatal pathologies. Their development and behavior was assessed at the age of four using Ages and Stages Questionnaire (ASQ-3), Children’s Behavior Questionnaire and Strength and Difficulties Questionnaire. Multivariate linear regression analyses were conducted to assess the association between CS and child outcomes. CS was associated with better scores in the Problem Solving domain of the ASQ in the whole sample. After stratifying by child sex, the positive association between CS and the Problem Solving domain was significant in boys, while no association was found in girls. Girls were rated less optimally in the Gross Motor domain of the ASQ when born via CS. Mode of birth was not associated with behavioral outcomes.

Date: 2009-06-04

Creator: Geraldine Butler, Matthew D. Rasmussen, Michael F. Lin, Manuel A.S. Santos, Sharadha, Sakthikumar, Carol A. Munro, Esther Rheinbay, Manfred Grabherr, Anja Forche, Jennifer L. Reedy, Ino Agrafioti, Martha B. Arnaud, Steven Bates, Alistair J.P. Brown, Sascha Brunke, Maria C. Costanzo, David A. Fitzpatrick, Piet W.J. De Groot, David Harris, Lois L. Hoyer, Bernhard Hube, Frans M. Klis, Chinnappa Kodira, Nicola Lennard, Mary E. Logue, Ronny Martin, Aaron M. Neiman, Elissavet Nikolaou, Michael A. Quail, Janet Quinn, Maria C. Santos

Access: Open access

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/α2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes. © 2009 Macmillan Publishers Limited. All rights reserved.

Date: 2021-06-01

Creator: Lea Takács, Jiří Štipl, Maria Gartstein, Samuel P. Putnam, Catherine, Monk

Access: Open access

Objective: Exposure to stress in pregnancy has been shown to affect fetal development with short- and long-term physiological and behavioral consequences for the offspring. Although social support is known to lower perceived stress, no prior study has investigated the buffering role of social support in the context of prenatal stress effects on infant temperament. The aim of this study was to examine interactive effects of prenatal stress and social support on several dimensions of infant temperament at 9 months postpartum. Study design: A total of 272 mothers completed the Perceived Stress Scale and the Perceived Social Support Scale in the 3rd trimester of pregnancy. Infant temperament was assessed by mothers at 9 months postpartum using the Infant Characteristics Questionnaire. Linear regression models were performed to assess the effects of perceived stress, social support, and their interaction on infant temperament. Results: Prenatal stress interacted with social support, such that prenatal stress increased infant unpredictability when social support was below -0.5 SD. Conclusions: Prenatal stress was found to be a risk factor for infant temperamental unpredictability when combined with low social support perceived by the mother during pregnancy. Support of others, not previously examined in this context, can reduce the impact of prenatal stress.

Date: 1993-01-01

Creator: A. S. Johnson, K. P. Sebens

Access: Open access

Per polyp feeding rate was independent of the horizontal planform area of colonies. At the lowest velocities, most particles were captured on the upstream edge or in the middle of colonies, but all positional bias in capture rate disappeared at higher velocities. Particle capture and increasing flow speed were negatively associated. There were small, but measurable, differences in mean tentacle length between corals feeding at different velocities. Velocity-dependent feeding rate at most velocities was thus related to changes in flow rather than to changes in feeding behavior. Experiments in which corals were turned upside down revealed that the increased capture rate for rightside-up corals feeding at low velocity could be almost entirely accounted for by gravitational deposition of particles on the corals' tentacles. The tentacles form a canopy within which water movement was slowed, possibly facilitating gravitational deposition of non-buoyant or sinking food particles. -from Authors

Date: 2015-01-01

Creator: Michael J. Frank, Chris Gagne, Erika Nyhus, Sean Masters, Thomas V., Wiecki, James F. Cavanagh, David Badre

Access: Open access

What are the neural dynamics of choice processes during reinforcement learning? Two largely separate literatures have examined dynamics of reinforcement learning (RL) as a function of experience but assuming a static choice process, or conversely, the dynamics of choice processes in decision making but based on static decision values. Here we show that human choice processes during RL are well described by a drift diffusion model (DDM) of decision making in which the learned trial-by-trial reward values are sequentially sampled, with a choice made when the value signal crosses a decision threshold. Moreover, simultaneous fMRI and EEG recordings revealed that this decision threshold is not fixed across trials but varies as a function of activity in the subthalamic nucleus (STN) and is further modulated by trial-by-trial measures of decision conflict and activity in the dorsomedial frontal cortex (pre-SMABOLDand mediofrontal theta in EEG). These findings provide converging multimodal evidence for a model in which decision threshold in reward-based tasks is adjusted as a function of communication from pre-SMA to STN when choices differ subtly in reward values, allowing more time to choose the statistically more rewarding option.

Date: 2009-12-01

Creator: Matthew Horak, Melanie Stein, Jennifer Taback

Access: Open access

We introduce a new method for computing the word length of an element of Thompson's group F with respect to a "consecutive" generating set of the form Xn = {x0,x1, ⋯, xn}, which is a subset of the standard infinite generating set for F. We use this method to show that (F, Xn) is not almost convex, and has pockets of increasing, though bounded, depth dependent on n. © 2009 World Scientific Publishing Company.

Date: 2006-09-15

Creator: Sean Cleary, Murray Elder, Jennifer Taback

Access: Open access

We study languages of geodesics in lamplighter groups and Thompson's group F. We show that the lamplighter groups Ln have infinitely many cone types, have no regular geodesic languages, and have 1-counter, context-free and counter geodesic languages with respect to certain generating sets. We show that the full language of geodesics with respect to one generating set for the lamplighter group is not counter but is context-free, while with respect to another generating set the full language of geodesics is counter and context-free. In Thompson's group F with respect to the standard finite generating set, we show there are infinitely many cone types and that there is no regular language of geodesics. We show that the existence of families of "seesaw" elements with respect to a given generating set in a finitely generated infinite group precludes a regular language of geodesics and guarantees infinitely many cone types with respect to that generating set. © 2005 Elsevier Inc. All rights reserved.

Date: 1991-07-01

Creator: David L. Murray, Bruce D. Kohorn

Access: Open access

Date: 2014-04-30

Creator: M. Ram Murty, Naomi Tanabe

Access: Open access

In 2011, M.R. Murty and V.K. Murty [10] proved that if L(s, χD) is the Dirichlet L-series attached a quadratic character χD, and L'(1, χD)=0, then eγ is transcendental. This paper investigates such phenomena in wider collections of L-functions, with a special emphasis on Artin L-functions. Instead of s=1, we consider s=1/2. More precisely, we prove thatexp (L'(1/2,χ)L(1/2,χ)-αγ) is transcendental with some rational number α. In particular, if we have L(1/2, χ)≠0 and L'(1/2, χ)=0 for some Artin L-series, we deduce the transcendence of eγ.

Date: 2020-03-01

Creator: Zoe M. Wood, Patricia L. Jones

Access: Open access

Philaenus spumarius (Meadow Spittlebug, Homoptera: Cercopoidea) is a cosmopolitan generalist insect that feeds on a wide repertoire of host plants in the field. We studied density and growth of Meadow Spittlebugs on a range of host plants on Kent Island, a boreal island in the Bay of Fundy, NB, Canada. The highest spittlebug densities were on Cirsium arvense (Canadian Thistle), although spittlebugs had larger body sizes on Solidago rugosa (Rough-stemmed Goldenrod) and Anaphalis margaritacea (Pearly Everlasting). We fertilized plots of Rough-stemmed Goldenrod in the field over 3 weeks to examine the effects of plant quality on development of Meadow Spittlebugs. Following fertilization, there were fewer nymphs present in fertilized plots than in unfertilized plots, indicating faster nymph maturation to adulthood on fertilized plants. This study offers an initial report of the host plants used by Meadow Spittlebugs in northeastern boreal habitat, variation in density and performance of the species on a range of host plants, and the effects of plant fertilization on spittlebug life history.