Showing 5021 - 5030 of 5701 Items
Reviews fall 2019-Special issue on Bauhaus centenary
Date: 2019-01-01
Creator: Kathleen James-Chakraborty, Pep Avilés, Claudia Tittel, Jill Pearlman
Access: Open access
Pandemic as method
Date: 2019-10-01
Creator: Belinda Kong
Access: Open access
- This essay deploys the concept of pandemic as a set of discursive relations rather than a neutral description of a natural phenomenon, arguing that pandemic discourse is a product of layered histories of power that in turn reproduces myriad forms of imperial and racial power in the new millennium. The essay aims to denaturalize the idea of infectious disease by reframing it as an assemblage of multiple histories of American geopower and biopower from the Cold War to the War on Terror. In particular, Asia and Asian bodies have been targeted by US discourses of infection and biosecurity as frontiers of bioterrorism and the diseased other. A contemporary example of this bioorientalism can be seen around the 2003 SARS epidemic, in which global discourses projected the source of contagion onto Asia and Asians. Pandemic as method can thus serve as a theoretical pathway for examining cultural concatenations of orientalism and biopower.
The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish
Date: 2019-06-12
Creator: Yann Gibert, Eric Samarut, Megan K. Ellis, William R. Jackman, Vincent, Laudet
Access: Open access
- The diversity of teeth patterns in actinopterygians is impressive with tooth rows in many locations in the oral and pharyngeal regions. The first-formed tooth has been hypothesized to serve as an initiator controlling the formation of the subsequent teeth. In zebrafish, the existence of the first tooth (named 4 V1) is puzzling as its replacement is induced before the opening of the mouth. Functionally, it has been shown that 4 V1 formation requires fibroblast growth factor (FGF) and retinoic acid (RA) signalling. Here, we show that the ablation of 4 V1 prevents the development of the dental row demonstrating its dependency over it. If endogenous levels of FGF and RA are restored after 4 V1 ablation, embryonic dentition starts again by de novo formation of a first tooth, followed by the dental row. Similarly, induction of anterior ectopic teeth induces subsequent tooth formation, demonstrating that the initiator tooth is necessary and sufficient for dental row formation, probably via FGF ligands released by 4 V1 to induce the formation of subsequent teeth. Our results show that by modifying the formation of the initiator tooth it is possible to control the formation of a dental row. This could help to explain the diversity of tooth patterns observed in actinopterygians and more broadly, how diverse traits evolved through molecular fine-tuning.
Images of New World Natives
Date: 1974-01-01
Creator: Jim Nicholson
Access: Open access
- Catalog ; with an introducton by James E. Nicholson : "Post-contact art of the northwest coast"
The Role of Competition and Patient Travel in Hospital Profits: Why Health Insurers Should Subsidize Patient Travel
Date: 2013-05-01
Creator: Joseph S Durgin
Access: Open access
- This paper explores the effects of patient travel distance on hospital profit margins, with consideration to the effects of travel subsidies on hospital pricing. We develop a model in which hospital agglomeration leads to a negative relationship between profit margins and patient travel distance, challenging the standard IO theory that profit margins are higher for firms with greater distances of customer travel. Using data on patient visits and hospital finances from the California Office of Statewide Health Planning and Development (OSHPD), we test our theory and confirm that a hospital tends to have less pricing power if it draws patients from beyond its local cluster. We then consider how our results might justify the subsidizing of patient travel by insurers and government payers. Lastly, we present an argument for why the ubiquitous Hirschman-Herfindahl index of market concentration can be robust to owner and system-level hospital cooperation.
The Legacy of James Bowdoin III
Date: 1994-01-01
Access: Open access
- The Legacy of James Bowdoin III (1994) was published to accompany a major year-long series of exhibitions and programs at the Bowdoin College Museum of Art commemorating the bicentennial of the founding of Bowdoin College. It includes essays by Kenneth E. Carpenter, Linda J. Docherty, Arthur M. Hussey, Clifton C. Olds, Richard H. Saunders, Susan E. Wegner.
Religion at Bowdoin College: A History
Date: 1981-01-01
Creator: Ernst Christian Helmreich
Access: Open access
- Religion at Bowdoin College: A History (1981), by Ernst Christian Helmreich, considers how people at Bowdoin have perceived religion, how they have felt religion should or should not be realized at the College, and how those views changed over the years.
Superhero Ecologies: An Environmental Reading of Contemporary Superhero Cinema
Date: 2019-05-01
Creator: Andrew McGowan
Access: Open access
Recruiting the Host's Immune System to Target Helicobacter pylori's Surface Glycans
Date: 2013-04-01
Creator: Pornchai Kaewsapsak, Onyinyechi Esonu, Danielle H. Dube
Access: Open access
- Due to the increased prevalence of bacterial strains that are resistant to existing antibiotics, there is an urgent need for new antibacterial strategies. Bacterial glycans are an attractive target for new treatments, as they are frequently linked to pathogenesis and contain distinctive structures that are absent in humans. We set out to develop a novel targeting strategy based on surface glycans present on the gastric pathogen Helicobacter pylori (Hp). In this study, metabolic labeling of bacterial glycans with an azide-containing sugar allowed selective delivery of immune stimulants to azide-covered Hp. We established that Hp's surface glycans are labeled by treatment with the metabolic substrate peracetylated N-azidoacetylglucosamine (Ac4GlcNAz). By contrast, mammalian cells treated with Ac4GlcNAz exhibited no incorporation of the chemical label within extracellular glycans. We further demonstrated that the Staudinger ligation between azides and phosphines proceeds under acidic conditions with only a small loss of efficiency. We then targeted azide-covered Hp with phosphines conjugated to the immune stimulant 2,4-dinitrophenyl (DNP), a compound capable of directing a host immune response against these cells. Finally, we report that immune effector cells catalyze selective damage in vitro to DNP-covered Hp in the presence of anti-DNP antibodies. The technology reported herein represents a novel strategy to target Hp based on its glycans. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.