Showing 5351 - 5360 of 5709 Items
Modulation of Responses to Phasic stretches by Neuromodulators GYS and SGRN in the Cardiac Central Pattern Generator of the American Lobster, H. americanus Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2016-05-01
Creator: Michael M Kang
Access: Access restricted to the Bowdoin Community
Named Professorships at Bowdoin College
Date: 1976-01-01
Access: Open access
- Named Professorships at Bowdoin College (1976) is a study of the named professorial chairs and other endowed funds designated directly for faculty support.
AMGSEFLamide, a member of a broadly conserved peptide family, modulates multiple neural networks in Homarus americanus
Date: 2019-01-01
Creator: Patsy S. Dickinson, Evyn S. Dickinson, Emily R. Oleisky, Cindy D. Rivera, Meredith E., Stanhope, Elizabeth A. Stemmler, J. Joe Hull, Andrew E. Christie
Access: Open access
- Recent genomic/transcriptomic studies have identified a novel peptide family whose members share the carboxyl terminal sequence –GSEFLamide. However, the presence/identity of the predicted isoforms of this peptide group have yet to be confirmed biochemically, and no physiological function has yet been ascribed to any member of this peptide family. To determine the extent to which GSEFLamides are conserved within the Arthropoda, we searched publicly accessible databases for genomic/transcriptomic evidence of their presence. GSEFLamides appear to be highly conserved within the Arthropoda, with the possible exception of the Insecta, in which sequence evidence was limited to the more basal orders. One crustacean in which GSEFLamides have been predicted using transcriptomics is the lobster, Homarus americanus. Expression of the previously published transcriptome-derived sequences was confirmed by reverse transcription (RT)-PCR of brain and eyestalk ganglia cDNAs; mass spectral analyses confirmed the presence of all six of the predicted GSEFLamide isoforms – IGSEFLamide, MGSEFLamide, AMGSEFLamide, VMGSEFLamide, ALGSEFLamide and AVGSEFLamide – in H. americanus brain extracts. AMGSEFLamide, of which there are multiple copies in the cloned transcripts, was the most abundant isoform detected in the brain. Because the GSEFLamides are present in the lobster nervous system, we hypothesized that they might function as neuromodulators, as is common for neuropeptides. We thus asked whether AMGSEFLamide modulates the rhythmic outputs of the cardiac ganglion and the stomatogastric ganglion. Physiological recordings showed that AMGSEFLamide potently modulates the motor patterns produced by both ganglia, suggesting that the GSEFLamides may serve as important and conserved modulators of rhythmic motor activity in arthropods.
Identifying a distinct developmental module in the zebrafish dentition
Date: 2018-01-01
Creator: Caleb Matthew Gordon
Access: Open access
- In the zebrafish pharynx, the first three teeth to form, 3V1, 4V1, and 5V1, have distinct adult and embryonic morphologies, suggesting that these teeth may form using different developmental pathways. Previous studies of gene expression profiles and mutant phenotypes in 3V1, 4V1, and 5V1 have identified four genes that might be involved in dissociating these tooth modules: pitx2b, eve1, pbx1a, and pbx1b. To determine how the developmental roles of these four genes differ across 3V1, 4V1, and 5V1, and obtain a better understanding of how these three teeth develop, I performed CRISPR/Cas9– mediated knockouts in each of these genes, or analyzed embryos from a stable transgenic mutant line where available, and observed the resulting tooth germs and mineralized tooth structures via fluorescence and confocal microscopy. Preliminary results implicate pitx2 as being required for tooth mineralization, offer a possible role for pbx1a, pbx1b, and eve1 in distinguishing the developmental pathway of 3V1, and suggest that 3V1 constitutes a distinct developmental module within the early ventral dentition.
An unbiased glimpse into the sex-specific effects of ketamine treatment on rats who have experienced early life adversity. Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2023-01-01
Creator: Lucia Marie O'Sullivan
Access: Access restricted to the Bowdoin Community
Identification of SYWKQCAFNAVSCFamide: A broadly conserved crustacean C-type allatostatin-like peptide with both neuromodulatory and cardioactive properties
Date: 2009-04-15
Creator: Patsy S. Dickinson, Teerawat Wiwatpanit, Emily R. Gabranski, Rachel J. Ackerman, Jake S., Stevens, Christopher R. Cashman, Elizabeth A. Stemmler, Andrew E. Christie
Access: Open access
- The allatostatins comprise three structurally distinct peptide families that regulate juvenile hormone production by the insect corpora allata. A-type family members contain the C-terminal motif -YXFGLamide and have been found in species from numerous arthropod taxa. Members of the B-type family exhibit a -WX6Wamide C-terminus and, like the A-type peptides, appear to be broadly conserved within the Arthropoda. By contrast, members of the C-type family, typified by the unblocked C-terminus -PISCF, a pyroglutamine blocked N-terminus, and a disulfide bridge between two internal Cys residues, have only been found in holometabolous insects, i.e. lepidopterans and dipterans. Here, using transcriptomics, we have identified SYWKQCAFNAVSCFamide (disulfide bridging predicted between the two Cys residues), a known honeybee and water flea C-typelike peptide, from the American lobster Homarus americanus (infraorder Astacidea). Using matrix assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS), a mass corresponding to that of SYWKQCAFNAVSCFamide was detected in the H. americanus brain, supporting the existence of this peptide and its theorized structure. Furthermore, SYWKQCAFNAVSCFamide was detected by MALDI-FTMS in neural tissues from five additional astacideans as well as 19 members of four other decapod infraorders (i.e. Achelata, Anomura, Brachyura and Thalassinidea), suggesting that it is a broadly conserved decapod peptide. In H. americanus, SYWKQCAFNAVSCFamide is capable of modulating the output of both the pyloric circuit of the stomatogastric nervous system and the heart. This is the first demonstration of bioactivity for this peptide in any species.
Evaluation of the Effectiveness of Probe Compounds at Predicting Anionic Pharmaceutical Sorption to Soils Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2021-01-01
Creator: Ben Cook
Access: Access restricted to the Bowdoin Community
Dispersive Shock Waves in Granular Chains This record is embargoed.
- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Ari Geisler
Access: Embargoed
"One Never Knew": David Foster Wallace and the Aesthetics of Consumption
Date: 2016-05-01
Creator: Jesse Ortiz
Access: Open access
- Increasingly, David Foster Wallace is becoming a cult figure among literary enthusiasts. His novels, essays, and short stories are all known for their poignant critiques of modern culture. Since his 2008 suicide, Wallace’s name has come to represent a way of thinking that rejects – and perhaps transcends – the hegemonic power of late capitalism. Wallace had a problem with pleasure. His writing often seemed to deflate or deconstruct what many people enjoy. For him, so much was “supposedly fun.” To understand Wallace’s relationship with pleasure, we must see how pleasure incorporates aesthetics and consumption. Wallace takes issue with the pleasure that comes from the aesthetics of cultural commodities. Irony produces pleasure, which turns culture into a desirable commodity. In my first chapter, I argue that Wallace’s essays challenge aesthetic pleasure by deconstructing self-reflexive irony. In his descriptions of consumer culture, Wallace evokes the feeling of disgust to undo the aesthetic pleasure of consumption. In my second chapter, I move to Infinite Jest to show how Wallace engages with irony while using it to exceed aesthetic pleasure. Infinite Jest challenges the hierarchy of aesthetics and suggests that deformity and waste can be beautiful and important. Infinite Jest demonstrates that, by trusting others instead of pursuing aesthetic ideals, people can build communities that are more honest and fulfilling than the pleasure of consumption.