Showing 3201 - 3250 of 6401 Items
Large buildings in winter
- Mounted photograph with a view of large buildings under snow.
Large building in winter
- Mounted photograph with an exterior view of a large building in winter
Forest gathering
- A group of well-dressed people gathering near a house surrounded by trees.
Identification of methylated proteins in the yeast small ribosomal subunit: A role for SPOUT methyltransferases in protein arginine methylation
Date: 2012-06-26
Creator: Brian D. Young, David I. Weiss, Cecilia I. Zurita-Lopez, Kristofor J. Webb, Steven G., Clarke, Anne E. McBride
Access: Open access
- We have characterized the posttranslational methylation of Rps2, Rps3, and Rps27a, three small ribosomal subunit proteins in the yeast Saccharomyces cerevisiae, using mass spectrometry and amino acid analysis. We found that Rps2 is substoichiometrically modified at arginine-10 by the Rmt1 methyltransferase. We demonstrated that Rps3 is stoichiometrically modified by ω- monomethylation at arginine-146 by mass spectrometric and site-directed mutagenic analyses. Substitution of alanine for arginine at position 146 is associated with slow cell growth, suggesting that the amino acid identity at this site may influence ribosomal function and/or biogenesis. Analysis of the three-dimensional structure of Rps3 in S. cerevisiae shows that arginine-146 makes contacts with the small subunit rRNA. Screening of deletion mutants encoding potential yeast methyltransferases revealed that the loss of the YOR021C gene results in the absence of methylation of Rps3. We demonstrated that recombinant Yor021c catalyzes ω-monomethylarginine formation when incubated with S-adenosylmethionine and hypomethylated ribosomes prepared from a YOR021C deletion strain. Interestingly, Yor021c belongs to the family of SPOUT methyltransferases that, to date, have only been shown to modify RNA substrates. Our findings suggest a wider role for SPOUT methyltransferases in nature. Finally, we have demonstrated the presence of a stoichiometrically methylated cysteine residue at position 39 of Rps27a in a zinc-cysteine cluster. The discovery of these three novel sites of protein modification within the small ribosomal subunit will now allow for an analysis of their functional roles in translation and possibly other cellular processes. © 2012 American Chemical Society.
From the Bowdoin College Collections: An Exhibition of European Art
Date: 1961-01-01
Access: Open access
- Catalog of an exhibition held at the Bowdoin College Oakes Center, Bar Harbor, Maine, July 5-Aug. 2, 1961.
Specific sequences within arginine-glycine-rich domains affect mRNA-binding protein function
Date: 2009-08-05
Creator: Anne E. McBride, Ana K. Conboy, Shanique P. Brown, Chaiyaboot Ariyachet, Kate L., Rutledge
Access: Open access
- The discovery of roles for arginine methylation in intracellular transport and mRNA splicing has focused attention on the methylated arginine-glycine (RG)-rich domains found in many eukaryotic RNA-binding proteins. Sequence similarity among these highly repetitive RG domains, combined with interactions between RG-rich proteins, raises the question of whether these regions are general interaction motifs or whether there is specificity within these domains. Using the essential Saccharomyces cerevisiae mRNA-binding protein Npl3 (ScNpl3) as a model system, we first tested the importance of the RG domain for protein function. While Npl3 lacking the RG domain could not support growth of cells lacking Npl3, surprisingly, expression of the RG domain alone supported partial growth of these cells. To address the specificity of this domain, we created chimeric forms of ScNpl3 with RG-rich domains of S. cerevisiae nucleolar proteins, Gar1 and Nop1 (ScGar1, ScNop1), or of the Candida albicans Npl3 ortholog (CaNpl3). Whereas the CaNpl3 RG chimeric protein retained nearly wild-type function in S. cerevisiae, the ScGar1 and ScNop1 RG domains significantly reduced Npl3 function and self-association, indicating RG domain specificity. Nuclear localization of Npl3 also requires specific RG sequences, yet heterologous RG domains allow similar modulation of Npl3 transport by arginine methylation.
Protein arginine methylation in Candida albicans: Role in nuclear transport
Date: 2007-07-01
Creator: Anne E. McBride, Cecilia Zurita-Lopez, Anthony Regis, Emily Blum, Ana, Conboy, Shannon Elf, Steven Clarke
Access: Open access
- Protein arginine methylation plays a key role in numerous eukaryotic processes, such as protein transport and signal transduction. In Candida albicans, two candidate protein arginine methyltransferases (PRMTs) have been identified from the genome sequencing project. Based on sequence comparison, C. albicans candidate PRMTs display similarity to Saccharomyces cerevisiae Hmt1 and Rmt2. Here we demonstrate functional homology of Hmt1 between C. albicans and S. cerevisiae: CaHmt1 supports growth of S. cerevisiae strains that require Hmt1, and CaHmt1 methylates Npl3, a major Hmt1 substrate, in S. cerevisiae. In C. albicans strains lacking CaHmt1, asymmetric dimethylarginine and ω-monomethylarginine levels are significantly decreased, indicating that Hmt1 is the major C. albicans type I PRMT1. Given the known effects of type I PRMTs on nuclear transport of RNA-binding proteins, we tested whether Hmt1 affects nuclear transport of a putative Npl3 ortholog in C. albicans. CaNpl3 allows partial growth of S. cerevisiae npl3Δ strains, but its arginine-glycine-rich C terminus can fully substitute for that of ScNpl3 and also directs methylation-sensitive association with ScNpl3. Expression of green fluorescent protein-tagged CaNpl3 proteins in C. albicans strains with and without CaHmt1 provides evidence for CaHmt1 facilitating export of CaNpl3 in this fungus. We have also identified the C. albicans Rmt2, a type IV fungus- and plant-specific PRMT, by amino acid analysis of an rmt2Δ/rmt2Δ strain, as well as biochemical evidence for additional cryptic PRMTs. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
MnNiO3 revisited with modern theoretical and experimental methods
Date: 2017-11-07
Creator: Allison L. Dzubak, Chandrima Mitra, Michael Chance, Stephen Kuhn, Gerald E., Jellison, Athena S. Sefat, Jaron T. Krogel, Fernando A. Reboredo
Access: Open access
- MnNiO3 is a strongly correlated transition metal oxide that has recently been investigated theoretically for its potential application as an oxygen-evolution photocatalyst. However, there is no experimental report on critical quantities such as the band gap or bulk modulus. Recent theoretical predictions with standard functionals such as LDA+U and HSE show large discrepancies in the band gaps (about 1.23 eV), depending on the nature of the functional used. Hence there is clearly a need for an accurate quantitative prediction of the band gap to gauge its utility as a photocatalyst. In this work, we present a diffusion quantum Monte Carlo study of the bulk properties of MnNiO3 and revisit the synthesis and experimental properties of the compound. We predict quasiparticle band gaps of 2.0(5) eV and 3.8(6) eV for the majority and minority spin channels, respectively, and an equilibrium volume of 92.8 Å3, which compares well to the experimental value of 94.4 Å3. A bulk modulus of 217 GPa is predicted for MnNiO3. We rationalize the difficulty for the formation of ordered ilmenite-type structure with specific sites for Ni and Mn to be potentially due to the formation of antisite defects that form during synthesis, which ultimately affects the physical properties of MnNiO3.
The power of context in networks: Ideal point models with social interactions
Date: 2019-01-01
Creator: Mohammad T. Irfan, Tucker Gordon
Access: Open access
- Game theory has been widely used for modeling strategic behaviors in networked multiagent systems. However, the context within which these strategic behaviors take place has received limited attention. We present a model of strategic behavior in networks that incorporates the behavioral context, focusing on the contextual aspects of congressional voting. One salient predictive model in political science is the ideal point model, which assigns each senator and each bill a number on the real line of political spectrum. We extend the classical ideal point model with network-structured interactions among senators. In contrast to the ideal point model's prediction of individual voting behavior, we predict joint voting behaviors in a game-theoretic fashion. The consideration of context allows our model to outperform previous models that solely focus on the networked interactions with no contextual parameters. We focus on two fundamental problems: learning the model using real-world data and computing stable outcomes of the model with a view to predicting joint voting behaviors and identifying most influential senators. We demonstrate the effectiveness of our model through experiments using data from the 114th U.S. Congress.
Walter K. Gutman Collection
Date: 1966-01-01
Access: Open access
- Exhibition catalogue from Bowdoin College Museum of Art. Includes and essay by Walter Gutman.
Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells
Date: 1996-03-19
Creator: A. E. Mcbride, A. Schlegel, K. Kirkegaard
Access: Open access
- A HeLa cDNA expression library was screened for human polypeptides that interacted with the poliovirus RNA-dependent RNA polymerase, 3D, using the two-hybrid system in the yeast Saccharomyces cerevisiae. Sam68 (Src- associated in mitosis, 68 kDa) emerged as the human cDNA that, when fused to a transcriptional activation domain, gave the strongest 3D interaction signal with a LexA-3D hybrid protein. 3D polymerase and Sam68 coimmunoprecipitated from infected human cell lysates with antibodies that recognized either protein. Upon poliovirus infection. Sam68 relocalized from the nucleus to the cytoplasm, where poliovirus replication occurs. Sam68 was isolated from infected cell lysates with an antibody that recognizes poliovirus protein 2C, suggesting that it is found on poliovirus-induced membranes upon which viral RNA synthesis occurs. These data, in combination with the known RNA- and protein-binding properties of Sam68, make Sam68 a strong candidate for a host protein with a functional role in poliovirus replication.
Virtual Communities Don’t Exist: Avoiding Digital Dualism in Studying Collaboration
Date: 2013-04-12
Creator: PJ Rey, Nathan Jurgenson
Access: Open access
- Effective collaboration in communities requires information sharing. Though digital media may have certain affordances that encourage us to communicate differently than in the past, the communities these media facilitate are no less real than communities bound together by voice or text. In this paper, we argue that idea of “virtual communities” is misleading. Communities and collaboration occur not in some virtual world or a new, cyber, space, but instead they are part of one reality influenced simultaneously by materiality and the various flows of information—digital included. In light of this argument, we implore researchers to take serious the influence of digitality, and, specific to this conference, those looking primarily at digitality to take seriously the materiality, bodies, history, and politics not separate from but deeply interpenetrating the digital. The changes in community organization brought about by digital media should not be thought of or called “virtual” (e.g., “virtual teams” as opposed to real ones), but instead part of one augmented community. Presented at the Collaborative Organizations & Social Media Conference at Bowdoin College on April 12, 2013.
As Maine Goes
Date: 1966-01-01
Access: Open access
- Catalogue of an exhibition held at the Bowdoin College Museum of Art.
Projected land-use change impacts on ecosystem services in the United States
Date: 2014-05-20
Creator: Joshua J. Lawler, David J. Lewis, Erik Nelson, Andrew J. Plantinga, Stephen, Polasky, John C. Withey, David P. Helmers, Sebastián Martinuzzi, Derric Penningtonh
Access: Open access
- Providing food, timber, energy, housing, and other goods and services, while maintaining ecosystem functions and biodiversity that underpin their sustainable supply, is one of the great challenges of our time. Understanding the drivers of land-use change and how policies can alter land-use change will be critical to meeting this challenge. Here we project land-use change in the contiguous United States to 2051 under two plausible baseline trajectories of economic conditions to illustrate how differences in underlying market forces can have large impacts on land-use with cascading effects on ecosystem services and wildlife habitat. We project a large increase in croplands (28.2 million ha) under a scenario with high crop demand mirroring conditions starting in 2007, compared with a loss of cropland (11.2 million ha) mirroring conditions in the 1990s. Projected land-use changes result in increases in carbon storage, timber production, food production from increased yields, and >10% decreases in habitat for 25% of modeled species. We also analyze policy alternatives designed to encourage forest cover and natural landscapes and reduce urban expansion. Although these policy scenarios modify baseline land-use patterns, they do not reverse powerful underlying trends. Policy interventions need to be aggressive to significantly alter underlying land-use change trends and shift the trajectory of ecosystem service provision.
Gendered Subjectivity in Refugee Resettlement Processes: From Somalia to Lewiston, ME
Date: 2018-01-01
Creator: Elena Gleed
Access: Open access
- Refugee Resettlement to the United States is a globalized and transnational process of making home. After Somali state collapse in 1991, more than a million displaced people fled to refugee camps across the Kenyan border. Today, over 12,000 Somali people now live in Lewiston, ME, an old mill town located along the Androscoggin River. As refugees are resettled by the United Nations High Commissioner for Refugees they enter a system created over fifty years ago in response to World War II. Using post-colonial and feminist scholarship, this project analyses the “female refugee” subject as she appears in the official discourse of resettlement processes. I trace the historical emergence of this subjectivity from an individual and work-based neoliberal American ethos to non-governmental organizations run by Somali women in Lewiston. Drawing from document analysis and ethnographic interviews, this paper explores the how Somali women are made to be “new American workers” in a process that combines western liberal feminism with ideas of integration and cultural orientation to the United States.
Using 'big data' to explain visits to lakes in 17 US states
Date: 2020-07-01
Creator: Erik Nelson, Maggie Rogers, Spencer Wood, Jesse Chung, Bonnie, Keeler
Access: Open access
- We use large dataset on US lakes from 17 states to estimate the relationship between summertime visits to lakes as proxied by social media use and the lakes' water quality, amenities, and surrounding landscape features and socioeconomic conditions. Prior to estimating these relationships we worked on 1) selecting a parsimonious set of explanatory variables from a roster of more than 100 lake attributes and 2) accounting for the non-random pattern of missing water quality data. These steps 1) improved the interpretability of the estimated visit models and 2) widened our estimated models' scope of statistical inference. We used Machine Learning techniques to select parsimonious sets of explanatory variables and multiple imputation to estimate water quality at lakes missing this data. We found the following relationships between summertime visits to lake and their attributes across the 17-state region. First, we estimated that every additional meter of average summer-time Secchi depth between 1995 and 2014 was associated with at least 7.0% more summer-time visits to a lake between 2005 to 2014, all else equal. Second, we consistently found that lake amenities, such as beaches, boat launches, and public toilets, were more powerful predictors of visits than water quality. Third, we also found that visits to a lake were strongly influenced by the lake's accessibility and its distance to nearby lakes and the amenities the nearby lakes offered. Finally, our results highlight the biased results that "big data"-based research on recreation can generate if non-random missing observation patterns in the data are not corrected.
Contingent planning under uncertainty via stochastic satisfiability
Date: 2003-07-01
Creator: Stephen M. Majercik, Michael L. Littman
Access: Open access
- We describe a new planning technique that efficiently solves probabilistic propositional contingent planning problems by converting them into instances of stochastic satisfiability (SSAT) and solving these problems instead. We make fundamental contributions in two areas: the solution of SSAT problems and the solution of stochastic planning problems. This is the first work extending the planning-as-satisfiability paradigm to stochastic domains. Our planner, ZANDER, can solve arbitrary, goal-oriented, finite-horizon partially observable Markov decision processes (POMDPs). An empirical study comparing ZANDER to seven other leading planners shows that its performance is competitive on a range of problems. © 2003 Elsevier Science B.V. All rights reserved.
Measuring Creative Performance of Teams Through Dynamic Semantic Social Network Analysis
Date: 2013-04-12
Creator: Peter Gloor
Access: Open access
- In this project we compare communication structure and content exchanged by members of creative, interdisciplinary teams of medical researchers, physicians, patients and caretakers with their creative output. We find that longitudinal social networking patterns and word usage predict creative performance. We collected the e-mail archives of 60 members of a community of researchers working on 12 projects improving various aspects of the daily lives of patients of Crohn’s disease. Our results indicate that more creative projects show a decrease in group density, while more actors are involved, and more emails are exchanged, suggesting that a more successful project attracts more attention from many different people. We also found that members of more creative projects use more emotional language, which gets more focused over time.
Subversive, mother, killjoy: Sexism against dilma rousseff and the social imaginary of Brazil’s rightward turn
Date: 2019-03-01
Creator: Joseph Jay Sosa
Access: Open access
- From resistance fighter against Brazil’s military dictatorship to its first female president, Dilma Rousseff’s biography follows the historic arc of democratization in Brazil. Her 2016 impeachment was also the culminating event of numerous crises that polarized Brazilian society. To supporters, Rousseff’s removal without evidence constitutes an abrogation of democracy. To critics, Rousseff had to answer for an economic recession and widespread corruption (though she was not implicated in any investigation). This article examines the social imaginaries of the rightward turn that made Rousseff’s removal possible. Moving across diverse sets of public culture-street protests, journalistic accounts, political observations, and Rousseff’s speeches-the article uses sexism against Rousseff as an analytic to deconstruct the cultural narratives of Brazil’s rightward turn. A first section considers conservative efforts to paint Rousseff as a political subversive. These accusations drew on long-standing, right-wing Brazilian tropes around people who don’t “act right” in the moral, sexual, and ideological fields. A second section reads the maternal metaphors of Rousseff’s governance strategies against conflicting political renderings of the family-pitting left-wing versions of family rooted in economic development against Evangelical Christian accounts of the family as a gender-normative unit. A third section argues that Rousseff’s response to the charges against her turned her (and those who argued her case) into what Sara Ahmed calls “feminist killjoys.” Ultimately, the question of sexism in Rousseff’s impeachment shows how deep-seated cultural conservatisms can be activated in a new era of democratic uncertainty.
A critical, analytical framework for the digital machine
Date: 2021-01-01
Creator: Crystal Hall, Eric Chown, Fernando Nascimento
Access: Open access
- The Faculty of Digital and Computational Studies (DCS) at Bowdoin College proposes a critical, analytical framework, referred to as the ‘4As,’ as an interdisciplinary means to interpret, evaluate, and create the data, operations, and devices of computing across all domains of knowledge production. Following other disciplines that have developed in symbiotic relationships to one another, DCS puts computation in conversation with fields from across the arts, humanities, physical, and social sciences. Our foundational premise is the bidirectional influence between these disciplines and digital artifacts and computation. The 4As (artifact, architecture, abstraction, and agency) benefit from both the scepticism of the liberal arts in the face of ubiquitous digital processes and the analytical opening for examining questions pertaining to creative and imaginative alternatives to the digital and computational status quo. We provide an ultra-contemporary case study to demonstrate the framework in use.
Locating noctiluca miliaris in the arabian sea: An optical proxy approach
Date: 2014-01-01
Creator: Patricia S. Thibodeau, Collin S. Roesler, Susan L. Drapeau, S. G. Prabhu Matondkar, Joaquim I., Goes, P. Jeremy Werdell
Access: Open access
- Coincident with shifting monsoon weather patterns over India, the phytoplankter Noctiluca miliaris has recently been observed to be dominating phytoplankton blooms in the northeastern Arabian Sea during the winter monsoons. Identifying the exact environmental and/or ecological conditions that favor this species has been hampered by the lack of concurrent environmental and biological observations on time and space scales relevant to ecologic and physiologic processes. We present a bio-optical proxy for N. miliaris measured on highly resolved depth scales coincident with hydrographic observations with the goal to identify conducive hydrographic conditions for the bloom. The proxy is derived from multichannel excitation chlorophyll a fluorescence and is validated with microscopy, pigment composition, and spectral absorption. Phytoplankton populations dominated by either diatoms or other dinoflagellates were additionally discerned. N. miliaris populations in full bloom were identified offshore in low-nutrient and low–N:P ratio surface waters within a narrow temperature and salinity range. These populations transitioned to high-biomass diatom-dominated coastal upwelling populations. A week later, the N. miliaris blooms were observed in declining phase, transitioning to very-low-biomass populations of non–N. miliaris dinoflagellates. There were no clear hydrographic conditions uniquely associated with the N. miliaris populations, although N. miliaris was not found in the upwelling or extremely oligotrophic waters. Taxonomic transitions were not discernible in the spatial structure of the bloom as identified by the ocean color Chl imagery, indicating that in situ observations may be necessary to resolve community structure, particularly for populations below the surface.
Xanthophyll cycle activity in two prominent arctic shrub species
Date: 2017-01-01
Creator: T.S. Magney, B.A. Logan, J.S. Reblin, N.T. Boelman, J.U.H., Eitel, H.E. Greaves, K.L. Griffin, C.M. Prager, L.A. Vierling
Access: Open access
The “New” Prosumer: Collaboration on the Digital and Material “New Means of Prosumption”
Date: 2013-04-13
Creator: George Ritzer
Access: Open access
- Many of “cyber-utopians” have lauded the Internet, especially social networking sites, for a variety of reasons, including making possible a dramatic and revolutionary increase in social collaboration (Benkler, 2007; Tapscott and Williams, 2006). The goal of this essay is to examine- and, at least in part, debunk- this claim from a new and unique sociological perspective- the relationship between collaboration and the “new means of prosumption”. Such an examination is suggested by the fact that collaboration is, by definition, a form of prosumption. That is, it involves one or more parties “producing” and other(s) “consuming” something of mutual interest and importance. However, the collaborative process, like prosumption more generally, is not as separable as all that. In fact, collaboration is a dialectical process in which those involved are continually changing their positions on the prosumption continuum (see below), sometimes they are more
Theta oscillations support active exploration in human spatial navigation
Date: 2022-11-15
Creator: Elizabeth R. Chrastil, Caroline Rice, Mathias Goncalves, Kylie N. Moore, Syanah C. Wynn, Chantal E. Stern, Erika Nyhus
Access: Open access
- Active navigation seems to yield better spatial knowledge than passive navigation, but it is unclear how active decision-making influences learning and memory. Here, we examined the contributions of theta oscillations to memory-related exploration while testing theories about how they contribute to active learning. Using electroencephalography (EEG), we tested individuals on a maze-learning task in which they made discrete decisions about where to explore at each choice point in the maze. Half the participants were free to make active decisions at each choice point, and the other half passively explored by selecting a marked choice (matched to active exploration) at each intersection. Critically, all decisions were made when stationary, decoupling the active decision-making process from movement and speed factors, which is another prominent potential role for theta oscillations. Participants were then tested on their knowledge of the maze by traveling from object A to object B within the maze. Results show an advantage for active decision-making during learning and indicate that the active group had greater theta power during choice points in exploration, particularly in midfrontal channels. These findings demonstrate that active exploration is associated with theta oscillations during human spatial navigation, and that these oscillations are not exclusively related to movement or speed. Results demonstrating increased theta oscillations in prefrontal regions suggest communication with the hippocampus and integration of new information into memory. We also found evidence for alpha oscillations during active navigation, suggesting a role for attention as well. This study finds support for a general mnemonic role for theta oscillations during navigational learning. © 2022
Interview with Sajjad Jaffer (Class of 1995) by Marina Henke
Date: 2019-11-09
Creator: Sajjad Jaffer
Access: Open access
- Sajjad Jaffer ('95) shares remarks on his experience as an international student from Tanzania. He explores his own journey towards finding a sense of belonging in Brunswick, Maine, worlds away from his life in eastern Africa. Jaffer speaks of the vast privilege that Bowdoin offered compared to his life at home, while also commenting on the difficulties of being a Muslim student and minority student on campus at the time. Jaffer shares the way that he continues to support Bowdoin students coming from African countries. “This is dedicated to the first American-born in my family- my daughter, Sophie Malaika Jaffer. Sophie recently started middle school as a 6th grader at Castilleja School in Palo Alto, CA. Castilleja has a tradition of picking a word as a theme for the academic year. For 2019-20, the theme is “Belonging”. Acknowledgments I want to thank J. Taylor Crandall ’76 for sharing 3 valuable lessons over the years: 1. It is the student who makes the school, not just the school that makes the student 2. Where there’s a will, there’s a way 3. Carpe diem – seize the day This reflection was influenced and reinforced by 5 notable Polar Bears: 1. Staci Williams ’90 for being my Bowdoin Big Sister 2. Geoffrey Canada ’74 who changed the world 3. Hari Kondabolu ’04 for challenging Hank Azaria, creator of The Simpsons 4. Kenneth Chenault ’73 who reminded us that business is the last frontier in the civil rights movement 5. Alvin Hall ’74 my Bowdoin Soul Brother About Sajjad graduated from Bowdoin in 1995 with a double major in Computer Science, Government and minor in Economics. Sajjad lives in Silicon Valley and co-founded a technology company that applies data science to private equity investing. The firm was founded on 25 years of research from Wharton where he did his MBA and serves on the board of the Wharton Customer Analytics research center."
Interview with Paul Wiley (Class of 1971) by Aisha Rickford
Date: 2019-11-09
Creator: Paul Wiley
Access: Open access
- Paul Wiley ‘71 talks about the “turnkey” moment that led him to know Bowdoin was where he wanted to go to college: when visiting Bowdoin as a prospective student, an incredible snowstorm hit Maine and he and his father arrived very late in the night Wiley talks about how surprised he was that Harry Warren, the Secretary of the College, was still awake waiting for them and made sure that they had everything they needed. Building upon this, Wiley shares some of the most important and impactful relationships he made at Bowdoin, particularly his football coach, who acted as a father figure, a gentle and forceful leader, and a great motivator. Wiley also talks about his special relationship with one of the Presidents of the College, Roger Howell, attending Bowdoin College with former College president Barry Mills ‘72, and being the first House Manager of AfAm.
The Architecture of Bowdoin College
Date: 1988-01-01
Creator: Patricia McGraw Anderson
Access: Open access
- The Architecture of Bowdoin College (1988), by Patricia McGraw Anderson, is the best single resource for the architectural history of Bowdoin’s campus buildings, gates, and memorials.
Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila
Date: 2021-06-01
Creator: Myron Child, Jack R. Bateman, Amir Jahangiri, Armando Reimer, Nicholas C., Lammers, Nica Sabouni, Diego Villamarin, Grace C. McKenzie-Smith, Justine E. Johnson, Daniel Jost, Hernan G. Garcia
Access: Open access
- 3D eukaryotic genome organization provides the structural basis for gene regulation. In Drosophila melanogaster, genome folding is characterized by somatic homolog pairing, where homologous chromosomes are intimately paired from end to end; however, how homologs identify one another and pair has remained mysterious. Recently, this process has been proposed to be driven by specifically interacting “buttons” encoded along chromosomes. Here, we turned this hypothesis into a quantitative biophysical model to demonstrate that a button-based mechanism can lead to chromosome-wide pairing. We tested our model using live-imaging measurements of chromosomal loci tagged with the MS2 and PP7 nascent RNA labeling systems. We show solid agreement between model predictions and experiments in the pairing dynamics of individual homologous loci. Our results strongly support a button-based mechanism of somatic homolog pairing in Drosophila and provide a theoretical framework for revealing the molecular identity and regulation of buttons.
Catalogue of the Marbles, Gems, Bronzes, and Coins of the Warren Collection of Greek and Roman Antiquities
Date: 1934-01-01
Access: Open access
- Descriptive catalogue of the Warren Classical Collection of Bowdoin College.
Robert Birmelin: Recent Paintings, Maine and New York
Date: 1980-01-01
Access: Open access
- Catalogue of an exhibition held at Bowdoin College Museum of Art, Mar. 14 to May 25, 1980.
Recent Acquisitions, 1961-1968
Date: 1968-01-01
Access: Open access
- "One thousand copies of this catalogue were set in Linotype Janson and printed by the Anthoensen Press, Portland, Maine. Design by Thomas Cornell"--P. [28]
Handbook of the Collections
Date: 1981-01-01
Creator: Margaret Burke
Access: Open access
- "Type composition by the Anthoensen Press."
Descriptive Catalogue of the Paintings, Sculpture and Drawings and of the Walker Collection
Date: 1930-01-01
Access: Open access
- "A considerably modified reprint of the preceding edition. [Descriptive catalogue of the art collections of Bowdoin college] compiled by the late Professor Henry Johnson along with a verbatim reprint of his descriptive catalogue of the Bowdoin collection of old masters' drawings."--Prefatory note
Thomas Cornell: Drawings & Prints
Date: 1971-01-01
Access: Open access
- Catalogue of an exhibition held at Bowdoin College Museum of Art, Nov. 5-Dec. 19, 1971 and the Art Museum, Princeton University, Jan. 14-Feb. 13, 1972.
Positive Effects of Nonnative Invasive Phragmites australis on Larval Bullfrogs
Date: 2012-08-30
Creator: Mary Rogalski
Access: Open access
islet reveals segmentation in the amphioxus hindbrain homolog
Date: 2000-04-01
Creator: William R. Jackman, James A. Langeland, Charles B. Kimmel
Access: Open access
- The vertebrate embryonic hindbrain is segmented into rhombomeres. Gene expression studies suggest that amphioxus, the closest invertebrate relative of vertebrates, has a hindbrain homolog. However, this region is not overtly segmented in amphioxus, raising the question of how hindbrain segmentation arose in chordate evolution. Vertebrate hindbrain segmentation includes the patterning of cranial motor neurons, which can be identified by their expression of the LIM-homeodomain transcription factor islet1. To learn if the amphioxus hindbrain homolog is cryptically segmented, we cloned an amphioxus gene closely related to islet1, which we named simply islet. We report that amphioxus islet expression includes a domain of segmentally arranged cells in the ventral hindbrain homolog. We hypothesize that these cells are developing motor neurons and reveal a form of hindbrain segmentation in amphioxus. Hence, vertebrate rhombomeres may derive from a cryptically segmented brain present in the amphioxus/vertebrate ancestor. Other islet expression domains provide evidence for amphioxus homologs of the pineal gland, adenohypophysis, and endocrine pancreas. Surprisingly, homologs of vertebrate islet1-expressing spinal motor neurons and Rohon-Beard sensory neurons appear to be absent. (C) 2000 Academic Press.
Invisible Women: Entrepreneurship, Innovation, and Family Firms in Nineteenth-Century France
Date: 2016-02-25
Creator: B. Zorina Khan
Access: Open access
- The French economy has been criticized for a lack of integration of women in business and for the prevalence of inefficient family firms. A sample drawn from patent and exhibition records is used to examine the role of women in enterprise and invention in France. Middle-class women were extensively engaged in entrepreneurship and innovation, and the empirical analysis indicates that their commercial efforts were significantly enhanced by association with family firms. Such formerly invisible achievements suggest a more productive role for family-based enterprises, as a means of incorporating relatively disadvantaged groups into the market economy as managers and entrepreneurs. This business model .... melds entrepreneurial passion with a long family tradition. - Wendel Company (1704-2014) 1
Certain Uncertainties: Chaos and the Human Experience
Date: 1996-01-01
Creator: Justin G. Schuetz
Access: Open access
- Accompanies an exhibition held at the Bowdoin College Museum of Art from April 17 through June 2, 1996. "This brochure is published with funding from the Andrew W. Mellon Foundation."--Colophon