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Interview with George Mitchell (1) by Andrea L’Hommedieu and Mike Hastings

Date: 2008-08-19

Creator: George J Mitchell

Access: Open access

Biographial Note

George J. Mitchell was born on August 20, 1933, in Waterville, Maine, to Mary Saad, a factory worker, and George Mitchell, a laborer. Senator Mitchell spent his youth in Waterville. After receiving his bachelor's degree from Bowdoin College in 1954, he served as an officer in the U.S. Army Counter Intelligence Corps until 1956. In 1960 he earned a law degree from Georgetown University. Mitchell worked for Senator Edmund S. Muskie as executive assistant and as deputy campaign manager during Muskie's 1972 presidential campaign. He later became U.S. senator (D-Maine) 1980-1995, Senate majority leader 1989-1995, and, upon his retirement from the Senate, special advisor on Northern Ireland 1995-1998. Since 1998, Senator Mitchell has served on many boards and committees and has received high profile appointments including: chairman of the Sharm el-Sheikh International Fact-Finding Committee on the crisis between Israel and the Palestinian Authority (2000); overseer of the Red Cross Liberty Fund (2001); lead investigator into the illegal use of performance enhancing substances in Major League Baseball (2006); and special envoy for Palestinian-Israeli affairs (2009-2011).

Summary

Interview includes discussion of: early legal career; working for the Justice Department; working on Edmund S. Muskie’s Senate staff; Jensen, Baird law firm (1966-1977); divorce case story; assistant county attorney; chairman of the Maine Democratic Party (1965-1968); Democratic National Committeeman from Maine (1968-1977); U.S. attorney for Maine (1977-1979); drug cases and antique case; federal judge (1979-1980); Ed and Marshall Stern; 1968 Muskie vice presidential campaign; 1980 appointment to Senator Muskie’s Senate seat and Joseph Brennan; Larry Benoit; Paul Ziffren fund-raising story; 1974 Maine gubernatorial campaign; Tax Equity Act; Finance Committee appointment story; and relationship with Maine newspapers/press.



Bowdoin College Catalogue (1975-1976)

Date: 1976-01-01

Access: Open access

Bowdoin College Bulletin no. 398


Semaphorin-Induced Plasticity in the Nervous System of the Cricket, Gryllus bimaculatus

Date: 2021-01-01

Creator: Alicia G. Edwards

Access: Open access

The adult auditory system of the cricket, Gryllus bimaculatus, exhibits a rare example of neuronal plasticity. Upon deafferentation, we observe medial dendrites that normally respect the midline of the PTG in the central nervous system sprouting across the boundary and forming synaptic connections with the contralateral auditory afferents. The Horch Lab has investigated key molecular factors that might play a causal role in this paradigm. Specifically, the protein Sema1a.2 comes from a guidance molecule family and has a role in developmental neuronal plasticity in other organisms. In this study, I explored the role of Sema1a.2 in the neuronal plasticity of the adult auditory system of the cricket by conducting a series of dsRNA knockdown experiments targeting Sema1a.2 followed by backfill procedures in which we iontophoresed dye into the Ascending Neurons (ANs) to visualize the anatomical effects of the knockdown experiments using confocal microscopy. We found that there were no significant differences between animals injected with dsRNA against GFP and Sema1a.2 volume, with respect to qualitative and quantitative data. However, we believe with an increase in cohort size, the trends observed, particularly the effect of Sema1a.2 knockdowns on CWM and CBM volumes, will become more pronounced and significant. Potential future pathways could include conducting double knockdowns of Sema1a.2 and Sema2a to observe if these two proteins are working together to create a more obvious effect on midline crossing and branching. Other options also include looking into other protein families that might be the causing factor in this rare phenomenon (toll-like receptors).