Showing 3901 - 3950 of 7462 Items
Investigating the Role of Helicobacter pylori Glycan Biosynthesis in Modulating Host Immune Cell Recognition Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2023-01-01
Creator: Katharine Barrett
Access: Access restricted to the Bowdoin Community
Errandsphere Access to this record is restricted to members of the Bowdoin community. Log in here to view.
- Restriction End Date: 2026-06-01
Date: 2021-01-01
Creator: Aida Muratoglu
Access: Access restricted to the Bowdoin Community
Pheromones enhance somatosensory processing in newt brains through a vasotocin-dependent mechanism
Date: 2008-07-22
Creator: R. R. Thompson, P. S. Dickinson, J. D. Rose, K. A. Dakin, G. M., Civiello, A. Segerdahl, R. Bartlett
Access: Open access
- We tested whether the sex pheromones that stimulate courtship clasping in male roughskin newts do so, at least in part, by amplifying the somatosensory signals that directly trigger the motor pattern associated with clasping and, if so, whether that amplification is dependent on endogenous vasotocin (VT). Female olfactory stimuli increased the number of action potentials recorded in the medulla of males in response to tactile stimulation of the cloaca, which triggers the clasp motor reflex, as well as to tactile stimulation of the snout and hindlimb. That enhancement was blocked by exposing the medulla to a V1a receptor antagonist before pheromone exposure. However, the antagonist did not affect medullary responses to tactile stimuli in the absence of pheromone exposure, suggesting that pheromones amplify somatosensory signals by inducing endogenous VT release. The ability of VT to couple sensory systems together in response to social stimulation could allow this peptide to induce variable behavioural outcomes, depending on the immediate context of the social interaction and thus on the nature of the associated stimuli that are amplified. If widespread in vertebrates, this mechanism could account for some of the behavioural variability associated with this and related peptides both within and across species. © 2008 The Royal Society.
Long-term maintenance of channel distribution in a central pattern generator neuron by neuromodulatory inputs revealed by decentralization in organ culture
Date: 2001-09-15
Creator: Adi Mizrahi, Patsy S. Dickinson, Peter Kloppenburg, Valerie Fénelon, Deborah J., Baro, Ronald M. Harris-Warrick, Pierre Meyrand, John Simmers
Access: Open access
- Organotypic cultures of the lobster (Homarus gammarus) stomatogastric nervous system (STNS) were used to assess changes in membrane properties of neurons of the pyloric motor pattern-generating network in the long-term absence of neuromodulatory inputs to the stomatogastric ganglion (STG). Specifically, we investigated decentralization-induced changes in the distribution and density of the transient outward current, IA, which is encoded within the STG by the shal gene and plays an important role in shaping rhythmic bursting of pyloric neurons. Using an antibody against lobster shal K+ channels, we found shal immunoreactivity in the membranes of neuritic processes, but not somata, of STG neurons in 5 d cultured STNS with intact modulatory inputs. However, in 5 d decentralized STG, shal immunoreactivity was still seen in primary neurites but was likewise present in a subset of STG somata. Among the neurons displaying this altered shal localization was the pyloric dilator (PD) neuron, which remained rhythmically active in 5 d decentralized STG. Two-electrode voltage clamp was used to compare IA in synaptically isolated PD neurons in long-term decentralized STG and nondecentralized controls. Although the voltage dependence and kinetics of IA changed little with decentralization, the maximal conductance of IA in PD neurons increased by 43.4%. This increase was consistent with the decentralization-induced increase in shal protein expression, indicating an alteration in the density and distribution of functional A-channels. Our results suggest that, in addition to the short-term regulation of network function, modulatory inputs may also play a role, either directly or indirectly, in controlling channel number and distribution, thereby maintaining the biophysical character of neuronal targets on a long-term basis.
Quantification of dendritic and axonal growth after injury to the auditory system of the adult cricket gryllus bimaculatus
Date: 2013-09-27
Creator: Alexandra Pfister, Amy Johnson, Olaf Ellers, Hadley W. Horch
Access: Open access
- Dendrite and axon growth and branching during development are regulated by a complex set of intracellular and external signals. However, the cues that maintain or influence adult neuronal morphology are less well understood. Injury and deafferentation tend to have negative effects on adult nervous systems. An interesting example of injury-induced compensatory growth is seen in the cricket, Gryllus bimaculatus. After unilateral loss of an ear in the adult cricket, auditory neurons within the central nervous system (CNS) sprout to compensate for the injury. Specifically, after being deafferented, ascending neurons (AN-1 and AN-2) send dendrites across the midline of the prothoracic ganglion where they receive input from auditory afferents that project through the contralateral auditory nerve (N5). Deafferentation also triggers contralateral N5 axonal growth. In this study, we quantified AN dendritic and N5 axonal growth at 30 h, as well as at 3, 5, 7, 14, and 20 days after deafferentation in adult crickets. Significant differences in the rates of dendritic growth between males and females were noted. In females, dendritic growth rates were non-linear; a rapid burst of dendritic extension in the first few days was followed by a plateau reached at 3 days after deafferentation. In males, however, dendritic growth rates were linear, with dendrites growing steadily over time and reaching lengths, on average, twice as long as in females. On the other hand, rates of N5 axonal growth showed no significant sexual dimorphism and were linear. Within each animal, the growth rates of dendrites and axons were not correlated, indicating that independent factors likely influence dendritic and axonal growth in response to injury in this system. Our findings provide a basis for future study of the cellular features that allow differing dendrite and axon growth patterns as well as sexually dimorphic dendritic growth in response to deafferentation. © 2013 Pfister, Johnson, Ellers and Horch.
Economic Costs of Elevated Public Debt Levels During Banking-Crisis Recessions
Date: 2021-01-01
Creator: Gavin T Shilling
Access: Open access
- The Great Recession of 2007 and 2008 exposed the risks of excessive borrowing. We learned the essential economic principle that greater leverage harbors greater risk. Although this global economic contraction was driven primarily by booming private credit expansion, economically inefficient incentives in the public sector, such as short-term reelection concerns, may lead politicians to engage in rash deficit- financed, fiscal spending. The primary purpose of this research is to assess the economic costs of heightened, preexisting government leverage on real economic outcomes during recessionary periods, focusing on both banking and non-banking crisis recessions. In both advanced economies and emerging economies, this study confirms that banking recessions are associated with more severe economic contractions and more persistent output declines than normal recessions. In advanced economies, GDP recovers quickly and strongly with expansionary and supportive fiscal policy during low debt recessions, even with depressed private investment. While GDP recovers slowly and weakly with less expansionary fiscal policy during high debt recessions, even with strong private investment. Thus, the social marginal benefit of public sector investment exceeds the social marginal benefit of private sector investment in advanced economies. In emerging economies, GDP recovers quickly and strongly with strong private investment during high debt recessions, even with weak fiscal spending. While GDP recovers slowly and weakly with depressed private investment during low debt recessions, even with expansionary and supportive fiscal policy. Thus, the social marginal benefit of private sector investment exceeds the social marginal benefit of public sector investment in emerging economies.
Bowdoin College Catalogue (1961-1962)
Date: 1962-01-01
Access: Open access
- Bowdoin College Bulletin no. 342
Seasons Without Borders: the Ali Smith Quartet
Date: 2021-01-01
Creator: Claire M Burns
Access: Open access
- This project considers how the novels of contemporary Scottish author Ali Smith work to destabilize traditional constructions of temporal, formal, national, and gender borders. The motifs of the border and the border identity have been thematically pervasive in Scottish literary history, as reflected in the recurrence of the Scottish split identity. This thesis explores how the borders that have become essential to the construction of Scottish national literature, often relying on binaristic categorizations, have been disestablished in the contemporary era. Ali Smith’s novels, particularly the novels of her seasonal quartet, introduce forms and figures that highlight the instability of many of these borders, challenging fixed representations of the border identity. Through this focus on Scotland, Smith constructs a template for a consideration of national identity beyond the boundaries of Scotland, extending toward a more global sensibility.
AMGSEFLamide, a member of a broadly conserved peptide family, modulates multiple neural networks in Homarus americanus
Date: 2019-01-01
Creator: Patsy S. Dickinson, Evyn S. Dickinson, Emily R. Oleisky, Cindy D. Rivera, Meredith E., Stanhope, Elizabeth A. Stemmler, J. Joe Hull, Andrew E. Christie
Access: Open access
- Recent genomic/transcriptomic studies have identified a novel peptide family whose members share the carboxyl terminal sequence –GSEFLamide. However, the presence/identity of the predicted isoforms of this peptide group have yet to be confirmed biochemically, and no physiological function has yet been ascribed to any member of this peptide family. To determine the extent to which GSEFLamides are conserved within the Arthropoda, we searched publicly accessible databases for genomic/transcriptomic evidence of their presence. GSEFLamides appear to be highly conserved within the Arthropoda, with the possible exception of the Insecta, in which sequence evidence was limited to the more basal orders. One crustacean in which GSEFLamides have been predicted using transcriptomics is the lobster, Homarus americanus. Expression of the previously published transcriptome-derived sequences was confirmed by reverse transcription (RT)-PCR of brain and eyestalk ganglia cDNAs; mass spectral analyses confirmed the presence of all six of the predicted GSEFLamide isoforms – IGSEFLamide, MGSEFLamide, AMGSEFLamide, VMGSEFLamide, ALGSEFLamide and AVGSEFLamide – in H. americanus brain extracts. AMGSEFLamide, of which there are multiple copies in the cloned transcripts, was the most abundant isoform detected in the brain. Because the GSEFLamides are present in the lobster nervous system, we hypothesized that they might function as neuromodulators, as is common for neuropeptides. We thus asked whether AMGSEFLamide modulates the rhythmic outputs of the cardiac ganglion and the stomatogastric ganglion. Physiological recordings showed that AMGSEFLamide potently modulates the motor patterns produced by both ganglia, suggesting that the GSEFLamides may serve as important and conserved modulators of rhythmic motor activity in arthropods.
Characterization of the mature form of a β-defensin-like peptide, Hoa-D1, in the lobster Homarus americanus
Date: 2018-09-01
Creator: Giap H. Vu, Daniel Do, Cindy D. Rivera, Patsy S. Dickinson, Andrew E., Christie, Elizabeth A. Stemmler
Access: Open access
- We report on the characterization of the native form of an American lobster, Homarus americanus, β-defensin-like putative antimicrobial peptide, H. americanus defensin 1 (Hoa-D1), sequenced employing top-down and bottom-up peptidomic strategies using a sensitive, chip-based nanoLC-QTOF-MS/MS instrument. The sequence of Hoa-D1 was determined by mass spectrometry; it was found to contain three disulfide bonds and an amidated C-terminus. The sequence was further validated by searching publicly-accessible H. americanus expressed sequence tag (EST) and transcriptome shotgun assembly (TSA) datasets. Hoa-D1, SYVRScSSNGGDcVYRcYGNIINGAcSGSRVccRSGGGYamide (with c representing a cysteine participating in a disulfide bond), was shown to be related to β-defensin-like peptides previously reported from Panulirus japonicas and Panulirus argus. We found Hoa-D1 in H. americanus hemolymph, hemocytes, the supraoesophageal ganglion (brain), eyestalk ganglia, and pericardial organ extracts, as well as in the plasma of some hemolymph samples. Using discontinuous density gradient separations, we fractionatated hemocytes and localized Hoa-D1 to hemocyte sub-populations. While Hoa-D1 was detected in semigranulocytes and granulocytes using conventional proteomic strategies for analysis, the direct analysis of cell lysates exposed evidence of Hoa-D1 processing, including truncation of the C-terminal tyrosine residue, in the granulocytes, but not semigranulocytes. These measurements demonstrate the insights regarding post-translational modifications and peptide processing that can be revealed through the MS analysis of intact peptides. The identification of Hoa-D1 as a widely-distributed peptide in the lobster suggests the possibility that it may be pleiotropic, with functions in addition to its proposed role as an antimicrobial molecule in the innate immune system.
Brutal Encounters: Primitivity, Politics, and the Postmodern Revolution
Date: 2021-01-01
Creator: Archer Thomas
Access: Open access
- The switch from late modernism to postmodernism in Western aesthetic theory and criticism took place in the mid-to-late 20th century, radically changing the face of cultural criticism. Much has been written on how postmodernism broke from modernism, but what factors paved its way in the decades following the Second World War? This paper argues that postmodernism represents both a reaction to and a necessary evolution of late modernism, specifically as it manifests in architecture, politics, and the politics of architecture. It focuses on the crisis of confidence among Western left-wing circles following the upheaval of the Second World War and posits that, because of this upheaval, primitivism came to dominate the epistemology of a renewed modernism led by figures such as Clement Greenberg, Reyner Banham, and the practitioners of “the New Brutalism.” The paper then explores how the Western left-wing reaction to developments like decolonization and postwar modernization challenged primitivity’s newfound importance, resulting in a shift towards a “postmodern populism” in aesthetics and politics by the 1960s as described by Jean Baudrillard, Fredric Jameson, Robert Venturi, and Reyner Banham.
Bowdoin College Catalogue (1968-1969)
Date: 1969-01-01
Access: Open access
- Bowdoin College Bulletin no. 370
Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus
Date: 2020-03-01
Creator: Hadley W. Horch, Sara B. Spicer, Isabel I.C. Low, Colby T. Joncas, Eleanor D., Quenzer, Hikmah Okoya, Lisa M. Ledwidge, Harrison P. Fisher
Access: Open access
- Guidance cues act during development to guide growth cones to their proper targets in both the central and peripheral nervous systems. Experiments in many species indicate that guidance molecules also play important roles after development, though less is understood about their functions in the adult. The Semaphorin family of guidance cues, signaling through Plexin receptors, influences the development of both axons and dendrites in invertebrates. Semaphorin functions have been extensively explored in Drosophila melanogaster and some other Dipteran species, but little is known about their function in hemimetabolous insects. Here, we characterize sema1a and plexA in the cricket Gryllus bimaculatus. In fact, we found two distinct predicted Sema1a proteins in this species, Sema1a.1 and Sema1a.2, which shared only 48% identity at the amino acid level. We include a phylogenetic analysis that predicted that many other insect species, both holometabolous and hemimetabolous, express two Sema1a proteins as well. Finally, we used in situ hybridization to show that sema1a.1 and sema1a.2 expression patterns were spatially distinct in the embryo, and both roughly overlap with plexA. All three transcripts were also expressed in the adult brain, mainly in the mushroom bodies, though sema1a.2 was expressed most robustly. sema1a.2 was also expressed strongly in the adult thoracic ganglia while sema1a.1 was only weakly expressed and plexA was undetectable.
The Mérida Initiative and the Violence of Transnational Criminal Organizations in Mexico
Date: 2021-01-01
Creator: Brianna Madison Canning
Access: Open access
- Organized crime related violence in Mexico remains at unprecedented levels despite decades of effort and billions of dollars spent attempting to weaken Transnational Criminal Organizations (TCOs) through the Mérida Initiative (MI): a bilateral security partnership established in October 2007 between US President George W. Bush and Mexican President Felipe Calderón. The MI sought to combat TCOs (often called cartels), their drug trafficking operations, and their networks of corruption. However, since then TCOs have expanded their businesses beyond drug trafficking, and they have adopted violent practices that target civilians. Extortion, torture, murder, and human trafficking have become common as TCOs look to other illicit markets to make up for losses in drug profits, and to signal strength to their opponents. More specifically, the homicide rate in Mexico increased by more than 100% between 2007 and 2008, aligning with the creation of the initiative designed to have the opposite effect. However, case study research into the violence in Ciudad Juárez and Tijuana determined that the MI was not actually implemented until mid-2009 because of bureaucratic delays, meaning it did not impact the initial spike in homicides in Mexico in 2008. Instead, the violence starting in 2008 is a result of changing dynamics between and within TCOs, as they adapted to survive and maintain control of resources. By supporting the Mexican government’s drug war efforts over the next several years, the Mérida Initiative became one of many complex domestic and international factors that ultimately contributed to extreme levels of violence in Mexico.
Photochemistry of Cyano-Substituted 8-Amino-2-Naphthol This record is embargoed.
- Embargo End Date: 2026-05-20
Date: 2021-01-01
Creator: Jialin Xie
Access: Embargoed
Can Small Donations Have Big Consequences? Candidate Ideology, Small Donations, and Election Results in the 2016 and 2018 Congressional Cycles
Date: 2021-01-01
Creator: Michael Borecki
Access: Open access
- Small donors have provided an increased share of total campaign contributions in the 2016, 2018, and 2020 U.S. federal election cycles, including about $3 billion of the $14.4 billion raised in 2020. Campaign funding is still dominated by an influential set of large donors, but small donations may be the basis for an effective response to the disproportionate amount of “big money” in politics. This study investigates whether candidates who are more extreme perform better with small donors, and then examines the impact of small donations and overall funding on election results. These analyses were performed using linear sum-of-squares regression models. The results in Chapter 2 show that candidates who are more politically-extreme receive more of their funding from small donations, but perform worse in general elections when fundraising is equal. Chapter 3 shows that small donations do not have an impact on candidate performance in general elections more generally, but candidates who outraise their opponent also outperform relative to the district’s partisan lean. However, that effect disappears when looking only at elections decided by less than 10 percent of the vote. These results suggest that small donors are more likely to support candidates who are more politically polarized, but the effects of small donors on the makeup of Congress is marginal at best, at least as far as general election outcomes are concerned. The project concludes by considering reform proposals that seek to broaden the pool of Americans who donate small sums to political candidates.
How do long-term above-ground biomass dynamics vary between different forest stand types at Harvard Forest?
Date: 2023-01-01
Creator: Maya Y. Chandar-Kouba
Access: Open access
- Monitoring forest carbon storage is necessary in accurately modelling the global carbon cycle. In the Northeast, terrestrial forests represent a major carbon sink with above-ground biomass (AGB) accounting for 40% of stored forest carbon. Therefore, understanding how AGB varies spatiotemporally is essential in predicting future carbon storage. Repeated measurements in permanent, long-term plots provide an opportunity to examine how carbon stored in AGB is changing over time. I used 29 years of data from the Harvard Forest Environmental Monitoring Systems (HF EMS) Site to determine how stand composition, intrinsic factors, and extrinsic environmental factors influenced rates of carbon storage in AGB over time. Using a partition around medoids (PAM) clustering method, I separated the 34 ground plots at the EMS stand into their respective stand types. I found that each stand type at the HF EMS plots accumulates carbon at consistent rates throughout the study period, although rates of carbon accumulation between stands were significantly different. Red Pine stands experience a rapid decline in biomass in 2018 due to the introduction of the Southern Pine Beetle. Across all stand types, sporadic mortality events determine variations in yearly rates of carbon accumulation, although this has little significant influence on total AGB accumulation. Leaf area index (LAI) and foliar N contents have no effect on growth increments. Extrinsic environmental variables had mixed effects on growth and mortality, highlighting the complexities of predicting forest carbon storage under changing climate conditions.
Rhythmic behaviors: Understanding neuromodulation at the neuromuscular level
Date: 2023-01-01
Creator: Kenneth Garcia
Access: Open access
- Neuromodulation allows for the flexibility of neural circuit dynamics and the outputs they produce. Studies of the stomatogastric nervous system (STNS) have expanded our knowledge on the actions of neuromodulators, small molecules that most often activate G-protein coupled receptors and reconfigure circuit activity and composition. In these systems, modulation has been found to occur at every level, from sensory-motor coupling to neuromuscular transmission (Harris-Warrick and Marder 1991). Neuromodulators have complex effects on motor output; they can alter the firing of individual neurons while also modulating muscle properties, neuromuscular transmission, and sensory neuron response to muscle activity (Fort et al. 2004). We investigated this further by recording the motor output produced by the gastric mill rhythm of the lobster STNS under neuromodulator conditions. How is this neuromuscular system as a whole modulated to produce motor flexibility? We hypothesized that these neuromodulators act on individual receptors of component neurons of central pattern generator (CPG)-effector system themselves and at the periphery, coordinately altering muscle contraction by altering all levels of the crustacean neuromuscular system. Application of NRNFLRFamide, RPCH, oxotremorine, and proctolin to the gastric mill 4 (gm4) muscles of the Cancer crab showed that neuromodulators that have been found to have variable, yet significant effects on the activity of the neurons of the STNS directly alter the activity of the gm4 muscles as well, suggesting that coordination of peripheral actions and direct neuronal modulation regulates patterned motor output.
Neptune City This record is embargoed.
- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Lily Randall
Access: Embargoed
A multifaceted analysis of Semaphorin-induced neuroplasticity in the nervous system of Gryllus bimaculatus Access to this record is restricted to members of the Bowdoin community. Log in here to view.
- Restriction End Date: 2028-06-01
Date: 2023-01-01
Creator: Ean Lev Small
Access: Access restricted to the Bowdoin Community
Invisible Ailments: A Collection
Date: 2023-01-01
Creator: Jane L. Godiner
Access: Open access
- "Invisible Ailments" is a collection of short stories that trace the depth, breath, and sweeping range of lived experiences of people struggling with mental illness. While it is a work of fiction, the people in these stories might feel eerily familiar — to your friends, your family members, your loved ones, or, if you're brave enough to admit it, yourself.
Live imaging of somatic homolog pairing in Drosophila supports a button-based mechanism for pairing facilitated by the genetic insulator gypsy This record is embargoed.
- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Holden D. Hadfield
Access: Embargoed
The Impact of Toll 6-1 Function on the Maintenance and Plasticity of the Gryllus bimaculatus Auditory System Access to this record is restricted to members of the Bowdoin community. Log in here to view.
- Restriction End Date: 2028-06-01
Date: 2023-01-01
Creator: Jada Scotland
Access: Access restricted to the Bowdoin Community
Characterizing the Roles of Toll7 in the Gryllus Bimaculatus Peripheral Nervous System Development
Date: 2023-01-01
Creator: Rowland Luo
Access: Open access
- The study of neuronal development could provide foundational information on neurogenesis and neuroplasticity. The small size and relatively simple nervous system of Orthoptera make them ideal models for neurodevelopmental studies. The peripheral nervous system development is an intricate and precise process that each sensory neurons are able to reach their central nervous system partners in a relatively short amount of time. Although the peripheral nervous system in limb buds and their genetic regulations are well understood in grasshopper embryos, few studies have explored the developing nervous system in a cricket model. Therefore, the first goal of the current experiment is to characterize the normal peripheral nervous system development in cricket embryos. Previous studies in Drosophila have suggested Toll6 and Toll7 receptors could serve as important targets for the neurotrophic-like factors Spaetzle2 and 5. Malfunctioning neurotrophic pathways could lead to abnormal nervous system development. Therefore, the second goal of the current study is to explore the roles of Toll7 in the development of the cricket peripheral nervous system. Immunohistochemical staining using anti-horseradish peroxidase (Anti-HRP) was used to illustrate crickets' embryonic developing peripheral nervous system in the limb buds from developmental stage 7.0 to 11.0. Cricket eggs were injected with Toll7 double stranded RNA (dsRNA) and rhodamine dye to suppress the Toll7 mRNA level. The control eggs were injected with GFP dsRNA and rhodamine dye. The peripheral nervous system development in cricket embryos is largely homologous to that observed in grasshopper embryos. All later-emerged sensory neurons followed the pathway established by the first pioneer neuron Ti1. Ti1 made stereotypical turns following the steering signals on epithelial and guidepost cell surfaces and eventually fasciculate with lateral motor axons from the central nervous system. When examining the peripheral nervous system development with Toll7 knockdown, a decrease in limb bud volume was observed at stage 7.7 and stage 8.0, suggesting Toll7’s potential roles in aiding cell-cell intercalation processes in Orthoptera embryos. Furthermore, a delay in Ti1 pioneer neuron development was observed with Toll7 knockdown at early developmental stages, providing evidence for Toll-Spaetzle pathway’s neurotrophic-like functions. The results of the current experiment provide the first description of the peripheral nervous system development in the cricket limb buds and further evidence of Toll-Spaetzle pathway’s neurotrophic properties.
Mathematically Modeling a Nonlinear, Passive Acoustic Filter This record is embargoed.
- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Bjorn Ludwig
Access: Embargoed
Playing the Fool: Analyzing the Phenomena of Iurodstvo In Contemporary Russian Cinema and Civil Society.
Date: 2023-01-01
Creator: Colby Silva Santana
Access: Open access
- Of Russia's cultural and religious icons, the holy fool (iurodivy) is quite possibly the most significant one of contemporary times. The holy fool – a historical and cultural character that feigns insanity to produce moral and spiritual reflections and hide the purity of their souls – has left its traces over a significant portion of Russia's literary history, postmodern tradition, and socio-political thought. In its uniquely positioned role as a powerful form of institutional critique, today taking shape in modern-day political protest performance culture, the holy fool has often been utilized to interrogate the intertwined relationship of the Russian state and the Orthodox Church. This analysis reviews the scholarship on holy foolery and how it has manifested in various fields of study. Although scholarship on this subject is significant, there exists a lack of research into representation of the holy fool in contemporary Russian cinema. Cinema is uniquely positioned to portray holy foolery, thanks to the unique form of spectatorship the film camera allows. This thesis analyzes several case studies of 21st-century Russian cinema that feature characters representing qualities of iurodstvo and its related models. In doing so, this work traces the history and development of iurodstvo through the lens of cinema and suggests new ways of understanding holy foolery's manifestation as a political tool.
The Shah Bano Case: An English-Language Democratic Practice in Post-Colonial India
Date: 2023-01-01
Creator: Hafsa Hossain
Access: Open access
- In 1985, Mohd. Ahmad Khan v. Shah Bano Begum, known commonly as the Shah Bano Case, became a flashpoint for Indian democracy. The Shah Bano case revolved around the maintenance of a divorced woman, not the first of its kind by any means. A case that sparked major social and political upheaval during a broader period of political turmoil, the Shah Bano case has long been interpreted as an expression of the crisis and contradictions between the democratic rights of women as citizens and the democratic rights of Muslims as a religious minority in the Indian nation-state. In the immediate aftermath of the case, critical feminist and post-colonial scholarship grappled with the dilemmas it involved, but to some extent remained caught up in those dilemmas. This thesis builds upon the important work of these and later scholars, but it also draws new attention to the specific role of the English-language public sphere in shaping the terms of debate that surrounded the case in the 1980s. This paper argues against the binary understanding of the landmark Shah Bano Case as either a failure or success of Indian secularism. I argue that the case and its aftermath demonstrate the continual nature of Indian secularism and democratic practice, especially laden in the post-Emergency era.
Hemocyte-derived proteins from the lobster, Homarus americanus: Changes in response to an LPS immune system challenge Access to this record is restricted to members of the Bowdoin community. Log in here to view.
- Restriction End Date: 2029-06-01
Date: 2024-01-01
Creator: Olivia Sewon Choi
Access: Access restricted to the Bowdoin Community
Racial Bias within Capital Punishment: Instructional Comprehension
Date: 2024-01-01
Creator: Marcus Gadsden
Access: Open access
- This dissertation examines the existence of racial bias within capital punishment. Since colonial times discriminatory death sentencing has impacted racial minorities, and despite living in a post-colonial epoch, the United States Justice system continues to produce alarming racial disparities. Consequently, both law reviews and social science journals indicate that race remains a significant factor in criminal trials. So, to what extent does racial bias influence capital punishment trials? Given that it does exist, how can it be alleviated? Through a statistical/qualitative analysis of psychological studies, Supreme Court cases, and jury instructions, this dissertation suggests that implicit cognitive bias continues to produce daunting realities in contemporary criminal punishment processes. Notably among juries, traditional judicial procedures have ostensibly triggered implicit bias and psychological intimidation, i.e. jury instructions. Moreover, do long and complicated jury instructions heighten instances of partial judgment? In Racial Bias within Capital Punishment: Instructional Comprehension, I argue that inaccessible jury instructions provide a space where jurors adhere to subtle racial preferences. Consequently, the swaying capacity of juries in capital punishment trials proceeds to arbitrarily produce discrepancies in sentencing rates.
Characterization of Retinoic Acid Signaling During Tooth Morphogenesis and Evolution in Danio rerio This record is embargoed.
- Embargo End Date: 2028-05-17
Date: 2023-01-01
Creator: Lyn Stephanie Miranda Portillo
Access: Embargoed
Thioglycosides modulate bacterial glycosylation Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2023-01-01
Creator: Isabella de la Luz Quintana
Access: Access restricted to the Bowdoin Community
"What's Outside the Window?": Evil, Literature, and Detection in Roberto Bolaño's Fiction This record is embargoed.
- Embargo End Date: 2026-05-18
Date: 2023-01-01
Creator: Andrew YH Chang
Access: Embargoed
“There’s Nothing More to Get From It”: Subverting Representation in Olivia Wenzel’s 1000 Serpentinen Angst and Sharon Dodua Otoo’s Adas Raum This record is embargoed.
- Embargo End Date: 2028-05-18
Date: 2023-01-01
Creator: Annika Moore
Access: Embargoed
On L-functions and the 1-Level Density
Date: 2023-01-01
Creator: Arav Agarwal
Access: Open access
- We begin with the classical study of the Riemann zeta function and Dirichlet L-functions. This includes a full exposition on one of the most useful ways of exploiting their connection with primes, namely, explicit formulae. We then proceed to introduce statistics of low-lying zeros of Dirichlet L-functions, discussing prior results of Fiorilli and Miller (2015) on the 1-level density of Dirichlet L-functions and their achievement in surpassing the prediction of the powerful Ratios Conjecture. Finally, we present our original work partially generalizing these results to the case of Hecke L-functions over imaginary quadratic fields.
Interview with Mike Hastings (1) by Andrea L’Hommedieu
Date: 2008-04-21
Creator: Michael 'Mike' M Hastings
Access: Open access
Biographial Note
Michael M. Hastings, a native of Morrill, Maine, graduated from Tilton School (NH) in 1968 and Bowdoin College in 1972. Following a year of graduate study in Public & International Affairs at George Washington University, he worked for seven years as a foreign and defense policy aide to Senator William S. Cohen (1973-1980) and for four years for Senator George J. Mitchell (1980-1984). In October 1984, he joined the international staff of Catholic Relief Services (CRS) and moved to Africa. Over a span of eight years, he worked as a CRS development administrator in Kenya, Tanzania, Togo and The Gambia. During the same period, he assisted in the provision of emergency food for people displaced by civil wars in the Southern Sudan and Liberia. In 1992, he returned to Maine to direct a “center for excellence,” focusing on aquaculture and economic development. Since 2004, he has worked for the University of Maine as its director of Research and Sponsored Programs. Between 1992 and 2008, he also served on several civic boards and institutions including the Maine Fishermen’s Forum, the Maine Oil Spill Advisory Committee, the Maine Indian Tribal State Commission, the Down East Institute, and the Maine Sea Grant Policy Advisory Committee. Between 1996 and 2001, he was elected three times to be a member of the Town Council of Hampden, Maine, where he resides with his wife, a middle school teacher.
Summary
The interview includes discussion of: the culture of Belfast, Maine during the ‘50s and ‘60s; family history; University of Maine campus atmosphere during the ‘60s; influential teachers; Bowdoin College atmosphere and cultural changes during the late ‘60s and early ‘70s; Ten-College Exchange; the draft and its effect on Bowdoin College students; influential Bowdoin College professors; Athern Daggett; Chris Potholm and connection to Bill Cohen; War Powers Act; working for the Cohen congressional campaign; political identity of Androscoggin and Oxford counties; the Cohen walk; differences between Maine’s Republican and Democratic parties; job responsibilities under Bill Cohen; description of Bill Cohen; appointment of George Mitchell to fill Edmund Muskie’s Senate seat; and moving from Senator Cohen to Senator Mitchell’s staff.
Interview with Steve Hart by Brien Williams
Date: 2008-12-11
Creator: W. 'Steve' Stephen Hart
Access: Open access
Biographial Note
Walter Stephen Hart was born January 17, 1955, in Washington, DC, to Peter William Hart and Mary Jane Strauss Hart; his parents were librarians. He attended Arizona State University, where he earned a degree in mass communications. He worked at a radio station in New Hampshire and covered the 1980 presidential primaries. He returned to school at Ball State, graduating with a degree in journalism and a minor in public relations, after which he moved to Maine, where his wife was working. He worked for Maine congressional candidate Phil Merrill in the 1982 primary, and after Merrill lost to John Kerry, Hart worked as Kerry’s press secretary. Hart was hired as a legislative assistant to Senator Mitchell in March of 1983. He was primarily responsible for Agriculture, Veterans’ Affairs, Governmental Affairs and Energy and Natural Resources issues. He remained on Mitchell’s staff until the senator’s retirement in January, 1995. At the time of this interview Hart was deputy director of legislative affairs for the USDA Forest Service.
Summary
Interview includes discussions of: 1982 congressional election in Maine; his role in Mitchell’s office; how Senate members and staff cooperate to get the best information; how Mitchell’s role changed when he became majority leader and how that impacted the staff; parochial interests; earmarks and the purpose they serve; Maine Blueberry Commission earmark; the Bicentennial Lighthouse Fund; the Coast Guard facility at Cape Elizabeth; maple syrup regulation on the Nurses Training Bill; the appropriations process; Mitchell staff salaries and his idea of “psychic remuneration”; the importance Mitchell placed on meeting with and responding to constituents; lobbyists’ role in providing information; the appropriations bill after hurricane Hugo; the senator’s division of time between the work of the Senate and being the public face of the Democratic Party; comparing Robert Byrd and Senator Mitchell as majority leaders; the reasoning behind retiring from the Senate when he did; anecdote about Hart and the chief of staff of Agriculture; Togus hearing on PTSD; the White Mountain National Forest nuclear waste disposal hearing; and the Northern Forest Study proposal hearings in Bangor.
Interview with Patrick Griffin by Brien Williams
Date: 2009-05-07
Creator: Patrick J Griffin
Access: Open access
Biographial Note
Patrick J. Griffin was born June 22, 1949, in New York to Daniel and Edith Griffin. He attended St. Peter’s College in New Jersey, then the University of Wisconsin-Milwaukee for graduate studies in urban policy. He worked as a Health, Education and Welfare fellow for a year, then spent a year on the Senate Budget Committee staff before becoming a member of Senator Byrd’s leadership staff, the Democratic Policy Committee staff, and later a Senate Floor staffer, where he met Senator Mitchell. He held the position of secretary of the Democratic Caucus, an elected position. He later started a lobbying firm with David Johnson, returning to politics to join the Clinton administration.
Summary
Interview includes discussion of: family, educational, and career background; responsibilities of Senate floor staff; majority leader race an Inouye; Iran-Contra; Acid Rain and Senator Byrd; Crime Bill; Byrd’s decision to move to the Appropriations Committee; Griffin’s relationship with Senator Byrd; experiences in the Clinton White House; health care debate; Mitchell-Clinton relationship; background on the Northern Ireland appointment and Clinton conversation; comparison of several majority leaders; and Tip O’Neill.
Interview with Debbie Ward by Andrea L’Hommedieu
Date: 2010-02-05
Creator: Deborah 'Debbie' B Ward
Access: Open access
Biographical Note
Deborah “Debbie” (Bedard) Ward was born in Saco, Maine, on March 22, 1951. She was graduated from Thornton Academy in 1969 and then attended Westbrook College. Subsequently, she worked as a secretary for the Westbrook College Department of Nursing. In 1972, she became involved in reviving the Saco Young Democrats, and in 1973 George Mitchell hired her as the first staff person for his gubernatorial campaign. After Mitchell lost the election to Jim Longley, Ward returned to Westbrook College to work as a house mother. She took the position of calendar clerk for the Maine state legislature, then was elected assistant clerk and held that position for eighteen years.
Summary
Interview includes discussion of: growing up in Saco in the 1950s and 1960s; splitting time between Virginia and Maine; reviving the Saco Young Democrats with Mike Aube and Barry Hobbins when Bill Hathaway ran against Margaret Chase Smith; campaigning as a part of the Young Democrats; being hired by Mitchell; Mitchell’s gubernatorial campaign volunteer base; working with Tony Buxton and Mike Aube; Mitchell’s running against and beating Joe Brennan in the primary; the state party structure; surprise at Longley winning the campaign; working as calendar clerk and assistant clerk for the state legislature; observing Mitchell’s progress to senator; and Joe Angelone.
Interview with James Ladd by Mike Hastings
Date: 2009-06-19
Creator: James L Ladd
Access: Open access
Biographial Note
James Loring Ladd was born February 18, 1933, in Milo, Maine, to Marianne Louise McKechnie and Vaughn Loring Ladd. He grew up in Milo and attended Foxcroft Academy. He was graduated from Bowdoin College in 1954 with a major in psychology; he and George Mitchell were classmates. Prior to the beginning of his senior year, he became married to Shirley Ladd; they have four children. He spent a year teaching, then was drafted into the Army and served in Korea for two years. He made a career in the real estate business in Milo, Maine, and is now retired.
Summary
Interview includes discussion of: growing up in Milo, Maine; traveling to Boston as a child; attending Foxcroft Academy; watching baseball and playing sports; attending Bowdoin College; George Mitchell at Bowdoin; the fraternities at Bowdoin; train service in Maine; participating in ROTC at Bowdoin and serving in Korea; teaching eighth grade at Mattawamkeag and coaching basketball and baseball at Newport High School; the Milo, Maine area; seeing George Mitchell when he would visit the local high school; Ladd’s children; and the increasing cost of a Bowdoin education.
Interview with Scott Hutchinson by Andrea L’Hommedieu
Date: 2009-10-07
Creator: Scott F Hutchinson
Access: Open access
Biographial Note
Scott Frederick Hutchinson was born in Gardiner, Maine, on April 16, 1929, to Helen Frances and Scott Arthur Hutchinson. His mother was a homemaker, and his father was employed by New England Telephone Company, rising in the ranks from line worker to vice president. Scott’s childhood was spent living in various communities throughout New England. He attended Northeastern University, and after college served in the Army during the Korean War. Coming back to Maine, he began a career in banking. During Ken Curtis’ campaign for governor, he served as treasurer. He then served as treasurer for Ed Muskie’s senatorial campaigns, vice presidential campaign, and as treasurer for Muskie's presidential primary race. He served as George Mitchell’s campaign treasurer.
Summary
Interview includes discussion of: working on Muskie’s staff with Mitchell in 1976; Maine gubernatorial campaign (1974); why Mitchell lost to Longley; Joe Angelone; Mitchell's running for Senate majority leader; Mitchell’s 1982 reelection campaign; David Emery; Mitchell’s relationship with Bill Cohen; the role of Independents in Mitchell’s campaigns; campaign changes for Mitchell between 1974 and 1982; and Hutchinson’s reaction to Mitchell’s announcement of retirement.
Interview with James Pierce (Class of 1969) by Emma Kellogg
Date: 2019-05-31
Creator: James Pierce
Access: Open access
- James A. “Jim” Pierce (Class of 1969) recounts his sight-unseen arrival to Bowdoin in 1965. He speaks about the fraternity system’s dominance over everything from food and lodging to social life. He describes the fraternities’ drinking culture and hazing rituals, as well as the “eccentric” nature of his own fraternity, Alpha Rho Upsilon. Pierce comments on the milieu of “rugged Christianity” he felt at Bowdoin, especially through mandatory chapel attendance. Additionally, he talks about his experiences with the Glee and Drama Clubs, Bowdoin’s academic rigor, and the prank group the Green Hornet Construction Company. Pierce also reflects on feeling the presence and impacts of the Vietnam War on campus.
Interview with Christopher Lierle (Class of 1989) by Meagan Doyle
Date: 2019-06-01
Creator: Christopher Lierle
Access: Open access
- Christopher “Chris” Lierle (Class of 1989) discusses adjusting to Bowdoin life from the West Coast and making close friendships despite the culture shock. He speaks about the importance of extracurricular activities during his time at Bowdoin and reminisces on his experiences with the football team and winning the Best Actor award in the One Act play competition. Lierle also reflects on not completing his Bowdoin education and the events in his life that led him to reconnect with the Bowdoin community twenty-five years later. He discusses the cherished relationships he forged during his time on campus and how they defined his time at college.