Showing 401 - 450 of 681 Items

Mitochondrial adaptation in the green crab hybrid zone of the Gulf of Maine

Date: 2024-01-01

Creator: Jared Lynch

Access: Open access

The mitochondrial genome has historically been relegated to a neutral genetic marker, but new evidence suggests mitochondrial DNA to be a target for adaptation to environmental stress. The invasive European green crab (Carcinus maenas) exemplifies this in the Gulf of Maine’s hybrid zone, where interbreeding populations exhibit thermal tolerances influenced by mitochondrial genotype. To better understand the mechanism behind this phenomenon, the effect of mitochondrial genotype on mitochondrial activity was tested by measuring mtDNA copy number (mtCN) and the activity of complex I, II, and IV of the electron transport system via high-resolution respirometry. Mitochondria isolated from frozen heart tissue were measured at three temperature points—5°C, 25°C, and 37°C—to represent thermal stresses and a control. It was predicted that cold-adapted haplogroups would exhibit both higher mtCN and increased activity for each complex, either across all temperatures or exclusively at 5°C compared to a warm-adapted haplogroup. Initial comparisons of mitochondria from fresh and frozen tissue at 25°C found lower activity for complex II and IV in frozen extracts, but they continued to be used for convenience. No differences were observed across haplogroups for mtCN or high-resolution respirometry, suggesting that mitochondrial activity does not underlie differences in thermal tolerance. However, temperature greatly influenced activity measurements with complex II and IV exhibiting the highest rates at 37°C while complex I exhibited optimal activity at 25°C. This study represents the first of its kind for C. maenas, providing a foundation for future experiments to continue exploring mitochondria in the context of adaptive evolution.


Miniature of Prescriptions of Identity: Jewish identities defined, questioned, and remembered in Early Modern Spain and early colonial America
Prescriptions of Identity: Jewish identities defined, questioned, and remembered in Early Modern Spain and early colonial America
This record is embargoed.
    • Embargo End Date: 2029-05-16

    Date: 2024-01-01

    Creator: Juliana Keyes Vandermark

    Access: Embargoed



      Miniature of Ionic Liquids as Additives for Metal-Organic Framework Crystallization
      Ionic Liquids as Additives for Metal-Organic Framework Crystallization
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      • Restriction End Date: 2027-06-01

        Date: 2024-01-01

        Creator: Oliver Wang

        Access: Access restricted to the Bowdoin Community



          Miniature of Distance Based Pre-clustering for Deep Time-Series Forecasting: A Data Selection Approach
          Distance Based Pre-clustering for Deep Time-Series Forecasting: A Data Selection Approach
          This record is embargoed.
            • Embargo End Date: 2025-05-16

            Date: 2024-01-01

            Creator: Leopold Felix Spieler

            Access: Embargoed



              Co-modulation of the Pyloric Circuit in the Stomatogastric Nervous System of the Cancer Borealis

              Date: 2025-01-01

              Creator: Margaret Broaddus

              Access: Open access

              ABSTRACT CHAPTER I: All nervous systems are influenced by circulating hormones, which can modulate neural circuits to produce different outputs from the same set of neurons. Invertebrate models, particularly crustaceans, serve as excellent models for studying neuromodulation because they contain neural circuits that continue to generate fictive activity when dissected out of the animal. The stomatogastric nervous system (STNS) of the Jonah Crab (Cancer borealis) has long been used to study neuromodulation due to its well-characterized circuits. Even in such a compact neural network, little is known about how these circuits are modulated, and this remains a question in all animals, particularly in humans. Here we investigated the modulation of the pyloric circuit by applying bulk hemolymph to the dissected STNS preparation. The hemolymph contains all of the circulating modulators, some of which have known effects on the pyloric rhythm (though many are still unknown). Interestingly, when hemolymph is applied to the isolated STNS, the pyloric rhythm is suppressed. This is surprising given that in vivo the STNS is continually exposed to hemolymph (the STG is situated within an artery, and thus, exposed to circulating hemolymph) and the pyloric rhythm is constitutively active. Therefore, I hypothesized that there are synaptically released neurotransmitters that excite the pyloric rhythm. To test this hypothesis, we applied three different excitatory modulators – proctolin, serotonin, and oxotremorine – separately in the presence of hemolymph. I found that proctolin and oxotremorine restore the pyloric rhythm in the presence of hemolymph. However, serotonin did not consistently overcome the inhibition of hemolymph. ABSTRACT CHAPTER II: A plethora of work has begun to identify how endogenous neural and hormonal modulators interact to influence the pyloric network. Here we examined the modulation of the stomatogastric nervous system (STNS) via two excitatory endogenous modulators CabTRP Ia and corazonin. CabTRP Ia and corazonin both excite the pyloric rhythm, but in distinct ways. Preliminary data by Nusbaum and Christie from 2003 suggested that an initial corazonin application gated a stronger response to subsequent CabTRP Ia when compared the inverse application of these neuromodulators. We sought to validate this gating phenomenon, but found no significant difference between the effects of the first and second applications of CabTRP Ia. Given that these animals are wild caught and surviving in a changing oceanic environment, it is possible that this modulatory effect in the Jonah Crab has changed over the last few decades due to environmentally driven shifts in receptor expression and channel conductances.


              Miniature of Redefining Warfare: The Role of International Humanitarian Law in Governing Cyber Conflict
              Redefining Warfare: The Role of International Humanitarian Law in Governing Cyber Conflict
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                  Date: 2025-01-01

                  Creator: Carina Lim-Huang

                  Access: Access restricted to the Bowdoin Community



                    Is Prompt Engineering Effective Enough? Why ChatGPT’s Bias Needs More Than a Quick Band-Aid Fix

                    Date: 2025-01-01

                    Creator: Hamda Abdirahman Hussein, Fatima K Kunjo

                    Access: Open access



                    Miniature of Multi-scale effects of environmental stress on Pinus ponderosa
                    Multi-scale effects of environmental stress on Pinus ponderosa
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                        Date: 2025-01-01

                        Creator: Cara Sydney Nova Fields

                        Access: Access restricted to the Bowdoin Community



                          Miniature of Shining a light on antimicrobial peptide pore formation: Developing a method to study alamethicin pore dynamics with polarized ATR-FTIR
                          Shining a light on antimicrobial peptide pore formation: Developing a method to study alamethicin pore dynamics with polarized ATR-FTIR
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                              Date: 2025-01-01

                              Creator: Rhys Edwards

                              Access: Access restricted to the Bowdoin Community



                                QE1 vs. Abenomics: A Channel-Based Comparison of Japan’s Quantitative Easing Attempts

                                Date: 2025-01-01

                                Creator: Sujan Garapati

                                Access: Open access

                                Since 2001, Japan has experienced two extended quantitative easing (QE) periods that aimed to address its low growth and deflationary environment. This paper investigates the transmission channels of the country’s QE policies during both periods: QE1 and Abenomics. Investigating three primary QE channels, signaling, inflation, and safety, the analysis identifies a signaling channel with different characteristics during both periods, no inflation channel, and a safety channel with different strengths during both periods. During QE1, event dates signaled low yields on short- and medium-term bonds but not on long-term bonds, suggesting a weak signaling channel. In contrast, under Abenomics, the signaling channel was strong for long-term bonds, reflecting a credible commitment to sustained low interest rates. Event dates in both periods were associated with deflation, so the evidence does not support the presence of an inflation channel. Across both periods, a significant safety channel was present. Investors paid a premium for safe assets that decreased yields as the BOJ purchased bonds, especially during Abenomics. The findings suggest that Abenomics was more successful at decreasing interest rates than QE1. Overall, this paper reveals that QE can effectively lower yields through signaling and safety effects but fails to raise inflation expectations in Japan.


                                Miniature of Developing an Exogenous Expression System 
for the Purification and Isolation of srGAP1
                                Developing an Exogenous Expression System for the Purification and Isolation of srGAP1
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                                    Date: 2025-01-01

                                    Creator: Philip Spyrou

                                    Access: Access restricted to the Bowdoin Community



                                      Miniature of Investigating the role of calcium-activated potassium channels in the stabilization of mammalian spinal locomotor activity
                                      Investigating the role of calcium-activated potassium channels in the stabilization of mammalian spinal locomotor activity
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                                          Date: 2025-01-01

                                          Creator: Aeri Ko

                                          Access: Access restricted to the Bowdoin Community



                                            Virtual Reality Accessibility with Predictive Trails

                                            Date: 2020-01-01

                                            Creator: Dani Paul Hove

                                            Access: Open access

                                            Comfortable locomotion in VR is an evolving problem. Given the high probability of vestibular-visual disconnect, and subsequent simulator sickness, new users face an uphill battle in adjusting to the technology. While natural locomotion offers the least chance of simulator sickness, the space, economic and accessibility barriers to it limit its effectiveness for a wider audience. Software-enabled locomotion circumvents much of these barriers, but has the greatest need for simulator sickness mitigation. This is especially true for standing VR experiences, where sex-biased differences in mitigation effectiveness are amplified (postural instability due to vection disproportionately affects women). Predictive trails were developed as a shareable Unity module in order to combat some of the gaps in current mitigation methods. Predictive trails use navigation meshes and path finding to plot the user’s available path according to their direction of vection. Some of the more prominent software methods each face distinct problems. Vignetting, while largely effective, restricts user field-of-vision (FoV), which in prolonged scenarios, has been shown to disproportionately lower women’s navigational ability. Virtual noses, while effective without introducing FoV restrictions, requires commercial licensing for use. Early testing of predictive trails proved effective on the principal investigator, but a wider user study - while approved - was unable to be carried out due to circumstances of the global health crisis. While the user study was planned around a seated experience, further study is required into the respective sex-biased effect on a standing VR experience. Additional investigation into performance is also required.


                                            Miniature of The Conspiracy of Balkis: Translating Monique Wittig's Feminist Novel "Les Guérillères"
                                            The Conspiracy of Balkis: Translating Monique Wittig's Feminist Novel "Les Guérillères"
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                                                Date: 2025-01-01

                                                Creator: Alyssa Nicole Bommer

                                                Access: Access restricted to the Bowdoin Community



                                                  Miniature of Freezing temperatures drive functional trait clustering more than habitat structure in eelgrass communities in the Gulf of Maine
                                                  Freezing temperatures drive functional trait clustering more than habitat structure in eelgrass communities in the Gulf of Maine
                                                  This record is embargoed.
                                                    • Embargo End Date: 2026-05-18

                                                    Date: 2023-01-01

                                                    Creator: Bridget Marjorie Patterson

                                                    Access: Embargoed



                                                      Miniature of Shining a Light on ‘Like Dissolves Like’: Effects of Cocrystals and Excipients on the Dissolution Performance of Mefenamic Acid
                                                      Shining a Light on ‘Like Dissolves Like’: Effects of Cocrystals and Excipients on the Dissolution Performance of Mefenamic Acid
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                                                          Date: 2025-01-01

                                                          Creator: Runqin Chen

                                                          Access: Access restricted to the Bowdoin Community




                                                            Miniature of Cell Adhesion in Arabidopsis thaliana
                                                            Cell Adhesion in Arabidopsis thaliana
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                                                                Date: 2019-05-01

                                                                Creator: Natasha Ann Belsky

                                                                Access: Access restricted to the Bowdoin Community



                                                                  Effects of Alkalinity and Ocean Acidification on Clam Shell Development in Phippsburg, ME

                                                                  Date: 2014-08-01

                                                                  Creator: Bailey Moritz

                                                                  Access: Open access

                                                                  With increased CO2 in the atmosphere from the burning of fossil fuels, more is absorbed into the surface ocean, causing a reaction that leads to lower pH. This process is known as ocean acidification, which has raised global concern. Over the past decade, the clam flat near Head Beach in Phippsburg has been reduced to approximately a sixth of its former productive area. The town of Phippsburg allots money every spring to seed the clam flat with juvenile soft-shell clams (Mya arenaria) in order to support the local clamming economy, but the clams are no longer growing in much of the mud flat. A possible explanation for this loss is acidification. In order to understand if ocean acidification is the cause, I collected water samples from the mud to test for alkalinity along a transect of 5 sites spanning productive and non-productive areas of the flat. Alkalinity is a measurement of the waters ability to buffer pH changes. Lower alkalinity could mean that clams would have more difficulty forming their calcium carbonate shells due to dissolution in low pH waters. Combined with the pH measurements gathered by my peer, Lloyd Anderson ‘16, we were able to calculate aragonite saturation state. Water with a saturation state below 1 is capable of dissolving calcium carbonate (aragonite) shells. A large portion of this research project was figuring out the best methodology to use for collecting data on the clam flat. The tested water needs to represent that which the clams are actually using while they are embedded in the mud. Additionally, juvenile clams only live in the upper centimeter or so of sediment. We followed methodologies used in past studies in Maine (Green et al 2013). Three pore water samples from each site were extracted and brought back to the lab to be filtered on 7 separate days throughout July. We began sampling 2 hours prior to low tide. I determined alkalinity using an automated titration system. Average alkalinity ranged from 2200-2500 μeq/kg. The results indicated that there was not a significant difference or pattern in alkalinity or saturation state between productive and unproductive areas of the clam flat (Fig. 1). Error bars in the figure represent variability at each site over the entire study period, while analytical reproducibility was ± 9.04 μeq/L. Large changes were observed merely from one day to another. Coastal ecosystems are complex and variations such as time of day, temperature, or productivity may have influences on the porewater characteristics (Duarte 2013). While ocean acidification does not appear to be the primary driving force behind the clams’ decline at this location, the saturation state was consistently quite low ( Final Report of research funded by the Rusack Coastal Studies Fellowship.


                                                                  Investigating the Effects of Climatic Change and Fire Dynamics on Peatland Carbon Accumulation in Coastal Labrador, Canada

                                                                  Date: 2014-08-01

                                                                  Creator: Anna Hall

                                                                  Access: Open access

                                                                  High-latitude peatlands store a large stock of carbon in accumulated belowground biomass, estimated at 500 ± 100 Gt C (Yu 2012). For comparison, the atmospheric C pool is estimated at about 775 Gt (IPCC 2007) making the peatland carbon pool a potentially significant player in the global carbon cycle. Peatland carbon storage is controlled by a balance between plant productivity and decomposition, with plant matter produced during the summer months accumulating from year to year rather than fully decomposing. Peatlands are sensitive to changes in climatic regime and have the potential to shift from a net sink of atmospheric C to a net source of C with future disturbance by climate warming (Yu 2012).There are two major predictions as to how climate change could affect peatland C accumulation. Warmer temperatures could cause faster decomposition of plant biomass and lead to C release to the atmosphere and a positive feedback effect on climate change (Schuur et al. 2008). If this is the case, current warming trends suggest that peatlands could release up to 100 Gt C to the atmosphere by the year 2100 (Davidson and Janssens 2006). Alternatively, warmer summer temperatures and a longer growing season could lead to faster peat production and therefore CO2 drawdown from the atmosphere, somewhat mitigating the effects of climate change (Schuur et al. 2008). A detailed study of past C accumulation rates over a known historical warm period gives insight into how peatlands may respond to future climate warming. This project focuses on C accumulation in peatlands in Labrador, Canada, over the past 8,000 years. Because Canadian peatlands store approximately 150 Gt C, approximately 1/3 of the global peatland carbon pool, it is important to understand how the dynamics of these peatlands could be affected by present and future climate warming (Tarnocai 2006). However, the majority of research has focused on central Canada, leaving significant knowledge gaps surrounding coastal Eastern Canada (vanBellen et al. 2012). Particular emphasis in this study was given to the Holocene Thermal Maximum (HTM) which occurred from 4-6 thousand years ago in Labrador, when summer temperatures were 0.5 – 1°C warmer than at present (Kerwin et al. 2004). This study also attempts to determine the effect of fires on rates of C storage in these peatlands. Lightning-ignited peat fires have the potential to consume stored biomass and release significant CO2 to the atmosphere (Tarnocai 2006). Six peat cores (out of a total of 14 collected in Labrador in 2013) were used for this study. Throughout the following year, calibrated radiocarbon dates, bulk density, and percent carbon were used to calculate carbon accumulation rates. This summer, areal charcoal concentration (a measure of macroscopic charcoal used as a proxy for fire severity) was used to determine the influence of fires in this region. From 8,000 years ago to the present, rates of C accumulation averaged 23.1 ± 6.7 gC m-2 yr-1. Accumulation rates were highest during the HTM, averaging 29.6 ± 2.4 g C m-2 yr-1. Samples containing macroscopic charcoal had an average concentration of 0.62 mm2 cm-3 with a maximum concentration found of 3.51 mm2 cm-3. These consistently low charcoal concentrations indicate that fire was neither common nor severe in Labrador peatlands. While Kuhry (1994) and Payette et al. (2012) found that fires in Canada occurred twice as frequently during the HTM than at present, no trends in fire severity were found in these cores, and there was no evidence that fires had a significant influence on C accumulation. Therefore, the C accumulation trend we see in Labrador is not controlled by fire and is likely either a direct result of temperature variation or of vegetational and hydrological shifts caused by changes in climate. This work supports a growing body of evidence from high latitude peatlands suggesting that future warming conditions could lead to increased soil C sequestration. Final Report of research funded by the Freedman Coastal Studies Fellowship.


                                                                  The Relationship between Nitrate Concentration and Phytoplankton Blooms in Harpswell Sound

                                                                  Date: 2014-08-01

                                                                  Creator: Sasha Kramer

                                                                  Access: Open access

                                                                  Phytoplankton require certain essential nutrients for growth. The Redfield ratio (Redfield, 1934) dictates an ideal element proportion of 106 carbon: 16 nitrogen: 1 phosphorus in order to maintain balanced phytoplankton growth through photosynthesis (Li et al., 2008). Under typical conditions, the concentration of nutrients present in the water directly controls the attainable phytoplankton yield (i.e. one inorganic nitrogen from nitrate yields one organic nitrogen in cellular form). While plankton that are starved of nutrients tend to die off quickly, plankton that are simply nutrient limited can adjust to constant but low levels of nutrient concentration (Cullen et al., 1992), often by adjusting their Redfield ratio. As an essential nutrient, nitrogen is a limiting factor for phytoplankton growth in the ocean (Dugdale, 1967). In oceanic and coastal ecosystems, dissolved nitrate (NO3-) is the most commonly available form of nitrogen (Zielinski et al., 2011). The formation of nutrients through microbial processes such as denitrification in deep water creates a source of nitrogen in the deep ocean (Arrigo, 2005). Phytoplankton growth is limited by both light and nutrients: therefore, the transport of nitrate into the euphotic zone controls the rate of primary production. In the Gulf of Maine, nitrate concentration varies with depth and season. Water density is determined by temperature and salinity; these qualities in turn control the depth of mixing and stratification, and thus the depth of the nitracline, the depth at which the high-nutrient deep waters are found (Townsend, 1998). An instrument known as the In Situ Ultraviolet Spectrophotometer (ISUS by Satlantic, Inc.) offers the ability to quantify nitrate concentrations based on optical properties. The instrument specifically measures the magnitude of absorption of ultraviolet light by dissolved nitrate molecules in the water. The concentration is determined from the ratio of the measured absorption coefficient to the molar absorption coefficient of nitrate. The ISUS is placed directly into the water at a site of specific interest—it measures the absorption and computes the nitrate concentration at this site every hour. This method of analysis gives superior stability, precision, and accuracy in data compared to a typical water sample analysis in a laboratory setting (Johnson & Coletti, 2002). For the past 4 years, an ISUS sensor has been deployed on the Bowdoin Buoy in Harpswell Sound collecting hourly observations of nitrate concentration concurrent with hourly observations of chlorophyll fluorescence (which can be used as a proxy for phytoplankton biomass). Once per week between May 21, 2014 and June 18, 2014, measurements of the depth distribution of salinity, temperature, density, chlorophyll fluorescence, and dissolved oxygen content were taken at the Bowdoin Buoy. Water samples were collected at five discrete depths each week, and were returned to the lab for analysis of chlorophyll concentration on the Turner fluorometer and nutrient concentration on the SmartChem. These laboratory analyses were used to calibrate and validate the buoy- and boat-based optical observations. The analysis of nitrate observations was performed in two phases. First, the variability in nitrate measured on the buoy since 2007 along with co-located discrete water samples was compared to a published historical dataset in order to place Harpswell Sound in the broader context of the Gulf of Maine. Second, the timeseries buoy observations of nitrate and chlorophyll were analyzed to determine temporal covariability. The historical nutrient and water quality data for the Gulf of Maine gathered by Rebuck et al. 2009 for 1990-2009 (in addition to unpublished data from 2010-2012) provided a broader spatial and temporal range for comparison with data from the Bowdoin Buoy in Harpswell Sound, Maine from 2007-2012. The historical nutrient data for the Gulf of Maine were measured in the lab; the nutrient data for Harpswell Sound was measured by the ISUS. There are relatively few match-ups for validation, but these points did show the correlation between the two methods. However, the similarity of the distribution of measured nitrate from water samples in lab and the in situ temperature and salinity characteristics of the sampled waters were very coherent with those measured by the ISUS, providing some quantitative validation. Future analysis of the ISUS data from summer 2014, in comparison to nutrient data from the water samples taken over the course of this summer, will further justify the validity of the ISUS data. A clear relationship between nitrate concentration and water temperature and nitrate concentration and salinity for both the Gulf of Maine and Harpswell Sound emerged (Figure 1). The highest concentrations of nitrate are found in the saltiest water (between 30-34 psu) and coldest water (between 3 and 12 degrees Celsius). This pattern was observed both generally in the Gulf of Maine and more specifically in Harpswell Sound, indicating that processes observed in Harpswell Sound are connected to broader scale oceanographic processes. These results also indicate that nutrients generated by deep ocean processes are dominant and river sources are negligible, a result that is not found in most areas. For both chlorophyll data and ISUS nitrate data, 2010 proved to be a model year with a clear and thorough timeseries from early February to late November. After analysis, the relationship between nitrate and chlorophyll showed a strong preliminary correlation of chlorophyll concentration (once again, as a proxy for phytoplankton biomass) increasing as nitrate concentration decreases (Figure 2). The low levels of phytoplankton consume the high levels of nitrate and therefore, as the bloom grows, the concentration of nitrate decreases proportionally. The expected dependence of chlorophyll concentration on nitrate concentration becomes incredibly clear through these results, similar to the results presented in Li et al., 2010. The ISUS data from 2007-2012 requires further processing in order to fully explore the relationship between chlorophyll and nitrate concentration on a pertinent timescale to bloom growth dynamics. While it is possible to construct a full time-series from the newly manipulated ISUS dataset after this summer work, it would be important and interesting to further examine the relationship between chlorophyll concentration and nitrate concentration in Harpswell Sound on daily, weekly, seasonal, and yearly timescales. This next step of investigation will require more time for data processing, but the work done this summer to validate the ISUS data and show the correlation between Harpswell Sound and the Gulf of Maine is incredibly promising for future work. Final report of research funded by the Doherty Coastal Studies Research Fellowship.


                                                                  “How the World Could Be in Spite of the Way That It Is”: Broadway as a Reflection of Contemporary American Sociopolitical Life

                                                                  Date: 2020-01-01

                                                                  Creator: Isabel Thomas

                                                                  Access: Open access

                                                                  Drawing on the plays and musicals of the 2018-2019 Broadway season, this thesis examines how theatre responds to the sociocultural, economic, and political conditions of society. Sociologists have largely overlooked theatre’s cultural influence, but Broadway productions act as social reflection by reproducing the conversations and inequalities of their context. Access to Broadway is limited, in various manners, by socioeconomic class, race, gender, ability, and age. As conversations about equity expand and audiences increasingly demand diversified representation, Broadway begins to shed the restraints of its conventions. In many regards, the recent changes fail in meaningfully transforming the Broadway institution. Those who control the stories on Broadway stages—producers, directors, writers—are disproportionately white and men, and the stories themselves predominantly uphold white privilege and heteronormativity. Economic pressures keep Broadway producers focused on high profit and cultural capital, at the expense of artistic and political risk. Broadway has particular affective power, employing the uniquely provocative effect of live theatre for unparalleled numbers of people. This influence is accompanied by responsibility to contribute to society’s progress rather than its stagnation, a responsibility which Broadway falls behind in fulfilling.


                                                                  Miniature of Advanced Mammals
                                                                  Advanced Mammals
                                                                  Access to this record is restricted to members of the Bowdoin community. Log in here to view.

                                                                      Date: 2020-01-01

                                                                      Creator: Emma Bezilla

                                                                      Access: Access restricted to the Bowdoin Community



                                                                        Miniature of The role of the ROG1 protein in pectin perception
                                                                        The role of the ROG1 protein in pectin perception
                                                                        Access to this record is restricted to members of the Bowdoin community. Log in here to view.

                                                                            Date: 2014-05-01

                                                                            Creator: Divya Hoon

                                                                            Access: Access restricted to the Bowdoin Community



                                                                              Miniature of Determination of the Relationship Between Peptoid Catalyst Oligomeric Length and Catalytic Enantioselectivity of Trifluoromethylation of Aldehydes
                                                                              Determination of the Relationship Between Peptoid Catalyst Oligomeric Length and Catalytic Enantioselectivity of Trifluoromethylation of Aldehydes
                                                                              Access to this record is restricted to members of the Bowdoin community. Log in here to view.
                                                                              • Restriction End Date: 2025-06-01

                                                                                Date: 2020-01-01

                                                                                Creator: Katharine Toll

                                                                                Access: Access restricted to the Bowdoin Community



                                                                                  Miniature of Role of SR-like RNA-binding protein 1 (Slr1) in hyphal tip localization of She3-transported mRNA in <i>Candida albicans</i>
                                                                                  Role of SR-like RNA-binding protein 1 (Slr1) in hyphal tip localization of She3-transported mRNA in Candida albicans
                                                                                  This record is embargoed.
                                                                                    • Embargo End Date: 2025-05-13

                                                                                    Date: 2020-01-01

                                                                                    Creator: Emma Beane

                                                                                    Access: Embargoed



                                                                                      From Left to Right? White Evangelical Politicization, GOP Incorporation, and the Effect of Party Affiliation on Group Opinion Change

                                                                                      Date: 2013-05-01

                                                                                      Creator: Devon B Shapiro

                                                                                      Access: Open access

                                                                                      While most white evangelicals in America have advocated moral, cultural, and social conservatism since the Founding, the group’s fiscal and social welfare preferences have been more volatile. Early 20th century evangelicals tended to be socially conservative, fiscally liberal, and, to the extent that they were politicized, mostly Democratic partisans. Since that time, not only have white evangelicals abandoned the Democratic Party, but also they have largely become fiscal and social welfare conservatives. I attempt to explain that transformation. I first examine the dynamics of white evangelical politicization and GOP incorporation, providing social and historical context to the political and partisan calculations of white evangelicals since the 1970s. Further, I propose a party affiliation effect that helps to explain white evangelical fiscal and social welfare conservatism. This effect asserts that partisanship penetrates individual conceptions of political issues. In the case of white evangelicals, I argue that the group affiliated with the GOP largely on the basis of socio-moral issues and concerns. Partly as a result of that affiliation, group opinion on fiscal policy began to drift to the right, toward the Republican Party status quo. Consistent with this claim, I provide longitudinal analyses of ANES and GSS data that shed light on the timing of opinion changes. As we would expect, white evangelical opinion on economic issues was closer to Democratic partisans during the 1960s and moved moved toward Republicans during the 1980s-1990s.


                                                                                      Miniature of Systemic Risk in the Airline Industry: Investigating the Effects of Network Interconnectedness on MES
                                                                                      Systemic Risk in the Airline Industry: Investigating the Effects of Network Interconnectedness on MES
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                                                                                          Date: 2020-01-01

                                                                                          Creator: Angela Goldshteyn

                                                                                          Access: Access restricted to the Bowdoin Community



                                                                                            Human Today, Posthuman Tomorrow in Margaret Atwood's MaddAddam Trilogy

                                                                                            Date: 2020-01-01

                                                                                            Creator: Benjamin Bousquet

                                                                                            Access: Open access

                                                                                            Human Today, Posthuman Tomorrow explores the relationship between the human and the nonhuman in Margaret Atwood’s MaddAddam trilogy through the lens of posthuman theory. Atwood’s trilogy depicts a dystopian, anthropocentric world that hinges upon an apocalyptic, man-made epidemic known as the Waterless Flood. Through posthuman theory, this thesis looks at ways to reconcile the oppositional and hierarchical relationship between the human and the nonhuman. The thesis is split into three main chapters, each of which engages a different posthuman theory. The first chapter addresses the concept of hybridity as it is elaborated by Rosi Braidotti’s The Posthuman. Next, the thesis turns to Donna Haraway’s “The Companion Species Manifesto” to address the ways human-animal relations in the trilogy are imagined as mutual and non-hierarchical. The last chapter turns to the pigoon/human relationship through Gilles Deleuze and Félix Guattari’s concept of becoming to understand the ways in which humans and pigoons build a new, non-oppositional relationship. In all, this thesis works to understand the stakes of the trilogy through posthumanism to argue that only through a posthuman understanding of the world are we able to erode oppositional differences between humans and nonhumans and create a future inhabitable for all.


                                                                                            Narrative, Identity, and Holocaust Memorialization in the United States

                                                                                            Date: 2020-01-01

                                                                                            Creator: Alexander Noah Kogan

                                                                                            Access: Open access

                                                                                            Narratives at Holocaust memorials and museums in the United States connect the Holocaust to present-day identities and weave the Holocaust into American history. Holocaust narratives––whether at the universal, national, or local level––draw moral lessons from the past. These narratives and their moral lessons redefine what constitutes the Holocaust and are determined by the needs and sentiments of the present. The sites of remembrance in this thesis at once show the significance of the Holocaust in American identities at both national and local levels, as well as encourage an active remembrance of the past that restructures these identities. The type of active remembrance and its purpose differs at each site, but each encourages a reconsideration of the past to find potentially applicable lessons for the present.


                                                                                            Governing the Internet: The Extraterritorial Effects of the General Data Protection Regulation

                                                                                            Date: 2020-01-01

                                                                                            Creator: Sasa Jovanovic

                                                                                            Access: Open access

                                                                                            The advent of the commercial Internet has introduced novel challenges to global governance because of the transnational nature of shared data flows, creating interdependence that may result in inter-state cooperation or competition. Data protection laws that are designed to ensure citizens’ right to privacy are one of the primary tool used by states to extend control over data flows. The European Union’s (EU) General Data Protection Regulation (2016) is widely regarded as the strongest data protection law in the world, and therefore may serve as a barrier to the openness of the Internet. The GDPR is both an instance of regulatory competition between the EU and US, but also heightens the need for cooperation to ensure the smooth functioning of online commerce. This paper shows that the EU is exporting the GDPR to jurisdictions such as the US via extraterritorial effects, even though the US has adopted an alternative legal approach to data protection. This paper seeks to explain the influence and limitations of the GDPR by considering factors such as the relative regulatory capabilities of the EU and the US as the result of their institutional and legal histories. It demonstrates that the EU has relied on complex interdependence to design a regulation like the GDPR, and it uses this regulatory competitive advantage alongside its soft power to promote its model of data protection, allowing the EU to obtain favorable outcomes in cooperation with the US.


                                                                                            Sex Sells: The Iconography of Sex Work in Contemporary Art Since 1973

                                                                                            Date: 2020-01-01

                                                                                            Creator: Mackenzie Philbrick

                                                                                            Access: Open access

                                                                                            Sex Sells: The Iconography of Sex Work in Contemporary Art Since 1973, explores contemporary renderings of the sex worker as a response to the heavily constructed formalist ideology of the “pure gaze” which privileged the heterosexual male voyeur. The analysis covers a broad range of media, sectioned off into three chapters—painting and photography, body art, and systemic critiques—to explore the affordances of each in critiquing the position of the voyeur as well as the larger capitalistic system. The first chapter investigates the ways in which realistic pictorial renderings depicted the sex worker to impose the voyeuristic viewing position of pornography onto the art-viewer. The second focuses on the relationship between the viewer and the commodified female body, as performers replaced the art commodity with their sexualized bodies. The third chapter discusses larger institutional critiques which illuminate the processes of class structuring in capitalism by recreating the capitalist exploitation or institutional shortcomings of our current sociopolitical system. Taken together, these works respond to the modernist commodification of the art object and female sexuality, which formalist viewing dynamics both reflected and promoted. The artists emphasize the real ramifications of class construction and relational or performative identity to understand how larger social processes play out on certain marginalized bodies, thus highlighting the inherent problems embedded in these social, cultural, and economic systems.


                                                                                            Campaigning for the Court: The Effect of Presidential Campaign Rhetoric on the Supreme Court

                                                                                            Date: 2021-01-01

                                                                                            Creator: Mackey O'Keefe

                                                                                            Access: Open access

                                                                                            This paper investigates how presidential candidates speak about the Supreme Court on the campaign trail, and how the ideological tenor of their rhetoric influences outcomes on the Court. Rhetoric is a powerful and well-researched tool of the presidency and has often been called “the power to persuade.” Much of judicial politics scholarship works to describe judicial decision making, investigating what constrains the actions and decisions of the Supreme Court. Though some scholarship has examined how presidential rhetoric affects the Supreme Court, little has been conducted in the area of presidential campaigns. This paper argues that presidential campaign rhetoric influences the Supreme Court by demonstrating that in the area of civil liberties the ideology of the winning presidential candidates' campaign rhetoric concerning the Supreme Court has a statistically significant effect on the percent of liberal rulings the Court issues one year after an election.


                                                                                            The United States’ and United Kingdom’s Responses to 2016 Russian Election Interference: Through the Lens of Bureaucratic Politics

                                                                                            Date: 2021-01-01

                                                                                            Creator: Katherine Davidson

                                                                                            Access: Open access

                                                                                            Russia’s 2016 disinformation campaign during the U.S. elections represented the first large-scale campaign against the United States and was intended to cause American citizens to question the fundamental security and resilience of U.S. democracy. A similar campaign during the 2016 U.K. Brexit referendum supported the campaign to leave the European Union. This paper assesses the policy formation process in the United States and United Kingdom in response to 2016 Russian disinformation using a bureaucratic politics framework. Focusing on the role of sub-state organizations in policy formation, the paper identifies challenges to establishing an effective policy response to foreign disinformation, particularly in the emergence of leadership and bargaining, and the impact of centralization of power in the U.K. Discussion of the shift in foreign policy context since the end of the Cold War, which provided a greater level of foreign policy consensus, as well as specific challenges presented by the cyber deterrence context, supplements insights from bureaucratic politics. Despite different governmental structures, both countries struggled to achieve collaborative and systematic policy processes; analysis reveals the lack of leadership and coordination in the United States and both the lack of compromise and effective fulfillment of responsibilities in the United Kingdom. Particular challenges of democracies responding to exercises of sharp power by authoritarian governments point to the need for a wholistic response from public and private entities and better definition of intelligence agencies’ responsibility to election security in the U.K.


                                                                                            Miniature of The Modulatory Role of the Hyperpolarization-Activated Inward Current and Adenosine A1 - Dopamine D1 Receptor Heteromers on Spinal Locomotor Activity
                                                                                            The Modulatory Role of the Hyperpolarization-Activated Inward Current and Adenosine A1 - Dopamine D1 Receptor Heteromers on Spinal Locomotor Activity
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                                                                                                Date: 2021-01-01

                                                                                                Creator: Andrew Moore

                                                                                                Access: Access restricted to the Bowdoin Community



                                                                                                  Miniature of Ultrasonic vocalization playback as an affective assay at both neural and behavioral levels: Implications for understanding adversity-induced emotional dysfunction
                                                                                                  Ultrasonic vocalization playback as an affective assay at both neural and behavioral levels: Implications for understanding adversity-induced emotional dysfunction
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                                                                                                      Date: 2023-01-01

                                                                                                      Creator: Sydney M Bonauto

                                                                                                      Access: Access restricted to the Bowdoin Community



                                                                                                        Miniature of Pragmatics and Accessibility in Referential Communication
                                                                                                        Pragmatics and Accessibility in Referential Communication
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                                                                                                          • Embargo End Date: 2028-05-18

                                                                                                          Date: 2023-01-01

                                                                                                          Creator: Thomas Mazzuchi

                                                                                                          Access: Embargoed



                                                                                                            The Independent State Legislature Theory and Partisan Gerrymandering: How Moore v. Harper May Reshape Congressional Elections

                                                                                                            Date: 2023-01-01

                                                                                                            Creator: Luke Porter

                                                                                                            Access: Open access

                                                                                                            In 2019, the U.S. Supreme Court ruled in Rucho v. Common Cause that partisan gerrymandering is not a justiciable question for federal courts. Four years later, the Court is reviewing a new case, Moore v. Harper. In Moore, the question presented is whether state courts can review partisan gerrymandering. The central question in Moore is the validity of the Independent State Legislature Theory. Proponents of the ISLT believe that state legislatures derive their authority to draw Congressional districts from the Federal Constitution and are therefore not subject to state-level checks and balances such as gubernatorial vetoes and state courts when redistricting. Critics argue that neither precedent nor the intent of the Framers grants state legislatures exclusive authority over redistricting. This paper analyzes the history of the Independent State Legislature Theory and outlines potential standards that the Court may adopt based off past-precedent. It then applies these standards to the redistricting process, arguing that nearly any form of the Independent State Legislature Theory would harm American democracy by making it easier for state legislatures to draw Congressional districts for partisan advantage. This paper concludes with strategies for mitigating the harm that would be caused if the Court legitimizes the Independent State Legislature Theory.


                                                                                                            Miniature of Relations between four-point amplitudes in N=4 supersymmetric Yang-Mills theory and N=8 supergravity at one, two, and three loops
                                                                                                            Relations between four-point amplitudes in N=4 supersymmetric Yang-Mills theory and N=8 supergravity at one, two, and three loops
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                                                                                                                Date: 2022-01-01

                                                                                                                Creator: Theodore Wolcott Wecker

                                                                                                                Access: Access restricted to the Bowdoin Community



                                                                                                                  Miniature of Directed Information Flow During Episodic Memory Retrieval at Theta Frequency
                                                                                                                  Directed Information Flow During Episodic Memory Retrieval at Theta Frequency
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                                                                                                                  • Restriction End Date: 2027-06-01

                                                                                                                    Date: 2022-01-01

                                                                                                                    Creator: Patrick F. Bloniasz

                                                                                                                    Access: Access restricted to the Bowdoin Community



                                                                                                                      Miniature of Characterization of Spaetzle Protein in the Mediterranean field cricket (<i>Gryllus bimaculatus</i>) and its role in central nervous system plasticity
                                                                                                                      Characterization of Spaetzle Protein in the Mediterranean field cricket (Gryllus bimaculatus) and its role in central nervous system plasticity
                                                                                                                      This record is embargoed.
                                                                                                                        • Embargo End Date: 2025-05-19

                                                                                                                        Date: 2022-01-01

                                                                                                                        Creator: Anthea L. Bell

                                                                                                                        Access: Embargoed



                                                                                                                          Miniature of Effect of Mindfulness Meditation on Long-Term Memory
                                                                                                                          Effect of Mindfulness Meditation on Long-Term Memory
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                                                                                                                              Date: 2016-05-01

                                                                                                                              Creator: William Andrew Engel

                                                                                                                              Access: Access restricted to the Bowdoin Community



                                                                                                                                Miniature of Regresando a Casa
                                                                                                                                Regresando a Casa
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                                                                                                                                    Date: 2023-01-01

                                                                                                                                    Creator: Edwin Sánchez Huizar

                                                                                                                                    Access: Access restricted to the Bowdoin Community



                                                                                                                                      From American Dream to American Reality: The Effect of Educational Expenditures on Intergenerational Mobility and the Great Gatsby Curve

                                                                                                                                      Date: 2022-01-01

                                                                                                                                      Creator: Isabel Krogh

                                                                                                                                      Access: Open access

                                                                                                                                      Income inequality and intergenerational mobility are two common measures of economic fairness in society. While they measure distinct ideas, they are significantly related in an inverse way across countries as well as across regions in the United States. This relationship is illustrated on the Great Gatsby Curve. Unequal access to education is one factor that has been found to drive the negative relationship between these two measures and therefore create the negatively sloping Great Gatsby Curve. Therefore, creating more equal access to education, such as through government spending, could lessen the connection between these two factors. The primary purpose of this research is to explore the effect of public educational expenditure on intergenerational mobility as well as on the slope of the Great Gatsby Curve. At the primary/secondary education level, this study finds that places with higher public spending on education tend to have higher levels of intergenerational mobility. However, no significant relationship is found between spending on tertiary education and intergenerational mobility. In addition, while higher primary/secondary educational spending is associated with a flatter Great Gatsby Curve at the school district level, these results were not consistent at the commuting zone level, so no strong conclusions can be made about the effect of public educational expenditures as a mediating factor of the Great Gatsby Curve.


                                                                                                                                      Miniature of This Is All for You: Stories
                                                                                                                                      This Is All for You: Stories
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                                                                                                                                          Date: 2023-01-01

                                                                                                                                          Creator: Catherine Crouch

                                                                                                                                          Access: Access restricted to the Bowdoin Community



                                                                                                                                            Bodies, Memories, Ghosts, and Objects or Telling a Memory

                                                                                                                                            Date: 2023-01-01

                                                                                                                                            Creator: Natsumi Lynne Meyer

                                                                                                                                            Access: Open access

                                                                                                                                            I think it started in December 2017, when my Mama sent me to Japan to take care of my grandparents, Baba and Jiji, alone. I had been to Japan almost every year since I was eleven years old, and several times before that too, but this was my first time without Mama. When Mama was there, Japan was filtered through her. I could poke bits of myself through her editing and approval. I could read street signs because of the way she read them, and I could understand my grandparents’ sighs from the timbre of her translation. That December, though, I had to see and hear alone. The tiny shakes in Baba’s legs and the indentation in Jiji’s forehead from when he fell down the stairs crystallized in my memory, and I had to write about it. This project includes a series of creative nonfiction and fiction pieces centered around telling my family stories. Writing from interviews, observations, and generational memories, I weave together these story fragments to discuss Asian American identity and immigration, WWII trauma, aging, and inheritance.


                                                                                                                                            James Joyce’s Prose Pedagogy: Language in Freirean Dialogue

                                                                                                                                            Date: 2023-01-01

                                                                                                                                            Creator: Jack McDermott Wellschlager

                                                                                                                                            Access: Open access

                                                                                                                                            My project concerns the pedagogical nature of James Joyce’s Ulysses. Across the various styles and forms of Ulysses’ chapters, or “episodes,” I theorize the pedagogy of James Joyce’s prose by tracking the ways that the text demands readers participate in a Freirean dialogue. I will also discuss how Ulysses understands language as a practice of resistance: the novel’s characters have personal linguistic practices that help them open up the worlds that occupy them. I will appreciate the control these characters take of their world as I argue, through Paulo Freire’s work, that no true change occurs without the presence of a cooperative worldbuilding effort.


                                                                                                                                            Modeling and Testing Consumer Engagement in the U.S. Organic Food Market

                                                                                                                                            Date: 2016-05-01

                                                                                                                                            Creator: John L Anderson

                                                                                                                                            Access: Open access

                                                                                                                                            This study specifies the types of consumers that participate in the U.S. organic market and investigates their revealed preferences. I propose three theoretical consumer types – indifferent consumers, informed organic food lovers, and uninformed organic food lovers – and conduct cross-sectional and time-trend analyses utilizing organic fruit purchase data compiled by The Neilsen Company. The cross-sectional analysis is estimated with a two-stage Heckman selection model, while the time-trend analysis uses simple descriptive statistics and a differenced OLS regression technique. Households are most likely to participate in the organic fruit market if they have a well-educated white or Asian head, are located in a metropolitan area on the West coast, have higher income, have young children, are married, and are making decisions in the spring, summer, or fall. However, households are estimated to purchase more organic fruit, conditional on participating, if they live in a rural area in regions other than the West coast. Having a higher income, being married, having a child less than six years old, being college-educated, and living in a metropolitan area on the West coast are all associated with more dedication to the organic fruit market over time. Households who increased their organic expenditures from 2011 to 2012 likely lived in metropolitan areas on the West coast. Average per-household contribution to the nationwide increase in organic fruit expenditures from 2011 to 2012 on the extensive and intensive margins is estimated to have been about $7 and $14, respectively. I posit relationships between empirical results and the theoretical consumer types.


                                                                                                                                            Miniature of Working Hands and Shifting Identities among Lobstermen in the Gulf of Maine’s Waterscape
                                                                                                                                            Working Hands and Shifting Identities among Lobstermen in the Gulf of Maine’s Waterscape
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                                                                                                                                                Date: 2023-01-01

                                                                                                                                                Creator: Meghan Gonzalez

                                                                                                                                                Access: Access restricted to the Bowdoin Community



                                                                                                                                                  Dietary diversity correlates with the neuromodulatory capacity of the stomatogastric nervous system in three species of majoid crabs

                                                                                                                                                  Date: 2023-01-01

                                                                                                                                                  Creator: Elise Martin

                                                                                                                                                  Access: Open access

                                                                                                                                                  This project sought to answer the following question: what is the relationship between the extent of neuromodulation in a nervous system, and the behavioral demands on that system? A well-characterized CPG neuronal circuit in decapod crustaceans, the stomatogastric nervous system (STNS), was used as a model circuit to answer this question. The stomatogastric ganglion (STG) in the STNS is responsible for muscular contractions in the stomach that aid in digestion. It has been shown that the neural networks in the STG are subject to neuromodulation. One feature of neuromodulation is that it enables circuit flexibility, which confers upon a system the ability to produce variable outputs in response to specific physiological demands. It was hypothesized that opportunistic feeders require more extensively modulated digestive systems compared to exclusive feeders, because opportunistic feeders require a greater variety of digestive outputs to digest their varied diets. In this study, Chionoecetes opilio and Libinia emarginata, the opportunistic feeders, showed greater neuromodulatory capacity of the STNS than Pugettia producta, the exclusive feeder. The hypothesis that neuromodulatory capacity of the STNS correlates with dietary diversity was supported. The results detailed in this study lend credence to the idea that evolutionary basis for neuromodulatory capacity of a system is related to the behavioral demands on that system.