Showing 961 - 970 of 5701 Items
Analysis of adhesion mutants in Arabidopsis thaliana This record is embargoed.
- Embargo End Date: 2025-05-14
Date: 2020-01-01
Creator: Bridgid Elizabeth Greed
Access: Embargoed
Bowdoin College Catalogue (1926-1927)
Date: 1927-01-01
Access: Open access
- Bowdoin College Bulletin no. 161
Interview with John Warner by Brien Williams
Date: 2009-03-31
Creator: John W. Warner
Access: Audio recording permanently restricted
- Biographical NoteJohn William Warner was born February 18, 1927, to John W. Warner and Martha Budd Warner. He grew up in Washington, D.C. and was graduated from Woodrow Wilson High School in 1945. He enlisted in the Navy after high school and is a veteran of World War II. After leaving the service he attended Washington & Lee University in Lexington, Virginia, graduating in 1949. He attended law school at the University of Virginia but left to serve in the Marines during the Korean War; subsequently, he received his law degree from George Washington University in 1953, served as a law clerk and became an assistant U.S. attorney before going into private practice in 1960, when he also served as a member of Richard Nixon’s advance staff during the 1960 presidential campaign. He married Catherine Conover Mellon in 1967 and they had three children before divorcing in 1973. In 1969, Warner was appointed undersecretary of the Navy, and then in 1972 he rose to be secretary of the Navy, a post he held for two years. President Ford appointed him director of the American Revolution Bicentennial Administration. In 1976, he married Elizabeth Taylor; they divorced in 1982. In 1978, Warner ran unsuccessfully in the Virginia Republican primary for the U.S. Senate; however, when the nominee was killed in a plane crash, he was asked to step in with only ten weeks until the election. Warner managed a narrow victory, earning the nickname “Landslide Johnny,” and remained in the Senate for thirty years, eventually retiring in 2009 as Virginia’s second longest serving senator. At the time of this interview he was a partner at the firm Hogan & Hartson, now Hogan Lovells. SummaryInterview includes discussion of: Warner’s entry into politics in 1960 as a member of then Vice President Nixon’s advance staff; opening Nixon’s Washington, D.C. office in 1968; serving as undersecretary, and later secretary, of the navy; working on the nation’s bicentennial; the 1978 Virginia Senate race; an anecdote about Warner and Mike Mansfield serving in the military; majority and minority leaders descriptions; the role of the filibuster in the Senate and how it has evolved; Mitchell’s Elizabeth Taylor joke and sense of humor in general; how the Republican caucus regarded Mitchell; an anecdote about Washington and Jefferson discussing the role of the Senate in the bicameral system; George Mitchell’s interest in environmental issues and the Clean Air Act; the ISTEA transportation bill; projects, or “pork”; the Gulf War Resolution; Mitchell’s views on military spending and awarding of shipbuilding contracts; BRAC proceedings and the Loring Air Force Base closure; the pendulum of political power; the political shift in 1980 with Reagan’s election; Reagan’s economic policies; how the culture of the Senate has changed; the increased importance of fund-raising; former House members in the Senate; Maine senators and distinguished careers; the Gang of Fourteen; Warner’s role in electing Bill Frist to majority leader; the Clintons’ attempt at health care reform; Warner’s role in encouraging Dole to run for majority leader; Hillary Clinton as a senator; Mitchell’s career since leaving the Senate; the challenges Mitchell faces as special envoy for the Middle East; Warner’s thoughts on leaving the Senate, and his plans for the future at the firm Hogan Lovells.
Bowdoin College Catalogue (1938-1939)
Date: 1939-01-01
Access: Open access
- Bowdoin College Bulletin no. 244
Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1
Date: 2017-05-01
Creator: Chaiyaboot Ariyachet, Christian Beißel, Xiang Li, Selena Lorrey, Olivia, Mackenzie, Patrick M. Martin, Katharine O'Brien, Tossapol Pholcharee, Sue Sim, Heike Krebber, Anne E. McBride
Access: Open access
- The morphological transition of the opportunistic fungal pathogen Candida albicans from budding to hyphal growth has been implicated in its ability to cause disease in animal models. Absence of SR-like RNA-binding protein Slr1 slows hyphal formation and decreases virulence in a systemic candidiasis model, suggesting a role for post-transcriptional regulation in these processes. SR (serine–arginine)-rich proteins influence multiple steps in mRNA metabolism and their localization and function are frequently controlled by modification. We now demonstrate that Slr1 binds to polyadenylated RNA and that its intracellular localization is modulated by phosphorylation and methylation. Wildtype Slr1-GFP is predominantly nuclear, but also co-fractionates with translating ribosomes. The non-phosphorylatable slr1-6SA-GFP protein, in which six serines in SR/RS clusters are substituted with alanines, primarily localizes to the cytoplasm in budding cells. Intriguingly, hyphal cells display a slr1-6SA-GFP focus at the tip near the Spitzenkörper, a vesicular structure involved in molecular trafficking to the tip. The presence of slr1-6SA-GFP hyphal tip foci is reduced in the absence of the mRNA-transport protein She3, suggesting that unphosphorylated Slr1 associates with mRNA–protein complexes transported to the tip. The impact of SLR1 deletion on hyphal formation and function thus may be partially due to a role in hyphal mRNA transport.
Invariants for tendex and vortex fields
Date: 2012-11-08
Creator: Kenneth A. Dennison, Thomas W. Baumgarte
Access: Open access
- Tendex and vortex fields, defined by the eigenvectors and eigenvalues of the electric and magnetic parts of the Weyl curvature tensor, form the basis of a recently developed approach to visualizing spacetime curvature. In analogy to electric and magnetic fields, these fields are coordinate-dependent. However, in a further analogy, we can form invariants from the tendex and vortex fields that are invariant under coordinate transformations, just as certain combinations of the electric and magnetic fields are invariant under coordinate transformations. We derive these invariants, and provide a simple, analytical demonstration for nonspherically symmetric slices of a Schwarzschild spacetime. © 2012 American Physical Society.
A simple family of analytical trumpet slices of the Schwarzschild spacetime
Date: 2014-06-07
Creator: Kenneth A. Dennison, Thomas W. Baumgarte
Access: Open access
- We describe a simple family of analytical coordinate systems for the Schwarzschild spacetime. The coordinates penetrate the horizon smoothly and are spatially isotropic. Spatial slices of constant coordinate time t feature a trumpet geometry with an asymptotically cylindrical end inside the horizon at a prescribed areal radius R0 (with 0 < R0 M) that serves as the free parameter for the family. The slices also have an asymptotically flat end at spatial infinity. In the limit R0 = 0 the spatial slices lose their trumpet geometry and become flat - in this limit, our coordinates reduce to Painlevé- Gullstrand coordinates. © 2014 IOP Publishing Ltd.
“Unstuck in Time and Space”: Time Travels in Teen Cinema Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2021-01-01
Creator: Hallowell Lyne
Access: Access restricted to the Bowdoin Community