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Miniature of Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions
Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions

Date: 2000-02-04

Creator: Anne E. McBride, Valerie H. Weiss, Heidi K. Kim, James M. Hogle, Pamela A., Silver

Access: Open access

Many eukaryotic RNA-binding proteins are modified by methylation of arginine residues. The yeast Saccharomyces cerevisiae contains one major arginine methyltransferase, Hmt1p/Rmt1p, which is not essential for normal cell growth. However, cells missing HMT1 and also bearing mutations in the mRNA-binding proteins Np13p or Cbp80p can no longer survive, providing genetic backgrounds in which to study Hmt1p function. We now demonstrate that the catalytically active form of Hmt1p is required for its activity in vivo. Amino acid changes in the putative Hmt1p S-adenosyl-L-methionine-binding site were generated and shown to be unable to catalyze methylation of Np13p in vitro and in vivo or to restore growth to strains that require HMT1. In addition these mutations affect nucleocytoplasmic transport of Np13p. A cold- sensitive mutant of Hmt1p was generated and showed reduced methylation of Np13p, but not of other substrates, at 14 °C. These results define new aspects of Hmt1 and reveal the importance of its activity in vivo.
Miniature of "Unexpected Gifts: Life With MS During a Pandemic" by Nora Pierson (Class of 2000)
"Unexpected Gifts: Life With MS During a Pandemic" by Nora Pierson (Class of 2000)

Date: 2020-01-01

Creator: Nora Pierson

Access: Open access

How having Multiple Sclerosis has prepared me for life in the time of Covid-19. The author is an alumna from the class of 2000.
Miniature of Bowdoin Orient, v. 55, no. 12
Bowdoin Orient, v. 55, no. 12

Date: 1925-10-21

Access: Open access

Miniature of Bowdoin Orient, v. 55, no. 17
Bowdoin Orient, v. 55, no. 17

Date: 1925-12-02

Access: Open access

Miniature of Bowdoin Orient, v. 55, no. 14
Bowdoin Orient, v. 55, no. 14

Date: 1925-11-04

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Miniature of Bowdoin Orient, v. 55, no. 28
Bowdoin Orient, v. 55, no. 28

Date: 1926-03-17

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Miniature of Bowdoin Orient, v. 7, no. 1
Bowdoin Orient, v. 7, no. 1

Date: 1877-04-25

Access: Open access

Miniature of Bowdoin Orient, v. 8, no. 14
Bowdoin Orient, v. 8, no. 14

Date: 1879-02-12

Access: Open access

Miniature of Bowdoin Orient, v. 9, no. 17
Bowdoin Orient, v. 9, no. 17

Date: 1880-03-31

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Miniature of Bowdoin Orient, v. 51, no. 11
Bowdoin Orient, v. 51, no. 11

Date: 1921-12-14

Access: Open access

Note there are two volumes of the Bowdoin Orient assigned numbered 51. The first comprises issues no. 1-10, April-June 1921. The second comprises issues no. 1-23, September 1921-March 1922.

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