Showing 1 - 3 of 3 Items
Natural variation in chromatin conformation among populations of Drosophila melanogaster
Date: 2021-01-01
Creator: Utku Ferah
Access: Open access
- The role of polymorphisms in protein-coding and non-coding regions of the genome during adaptive evolution has been a long-debated subject in evolutionary biology. Although the importance of coding-sequence polymorphisms during evolution has been well-documented, the influence of non-coding regions of the genome on phenotypic diversity and adaptive evolution remains less clear. Enhancers are cis-regulatory elements that dictate gene transcription rates, times, and locations; enhancers are located in noncoding regions and, when active, exhibit an open-chromatin conformation. In the current study, we identified putative enhancers that differ in chromatin conformation among three natural isolates of Drosophila melanogaster from different parts of the world. The genome-wide numbers of enhancers active in some natural isolates—but inactive in others—will provide insight into the amount of raw material available for evolution due to transcriptional regulatory variation.
Investigating enhancer regulation through chromatin conformation in Drosophila Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2020-01-01
Creator: Hannah D. Konkel
Access: Access restricted to the Bowdoin Community
Characterizing variation in enhancer usage within and between natural populations of Drosophila by comparing chromatin conformation in non-coding DNA This record is embargoed.
- Embargo End Date: 2027-05-19
Date: 2022-01-01
Creator: Serena Jonas
Access: Embargoed